Zobrazeno 1 - 10
of 132
pro vyhledávání: '"DAVID ARNOTT"'
Autor:
Ryan Raisner, Samir Kharbanda, Lingyan Jin, Edwin Jeng, Emily Chan, Mark Merchant, Peter M. Haverty, Russell Bainer, Tommy Cheung, David Arnott, E. Megan Flynn, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1722-1729 (2018)
Summary: Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However, the functional impact of this modification at enhancers is poorly understood. Here, we use a chemical genetics approach to acutely block the funct
Externí odkaz:
https://doaj.org/article/30f0b373eb01444dbff75e2a8755acdb
Autor:
Denise E. de Almeida Nagata, Eugene Y. Chiang, Suchit Jhunjhunwala, Patrick Caplazi, Vidhyalakshmi Arumugam, Zora Modrusan, Emily Chan, Mark Merchant, Lingyan Jin, David Arnott, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne, Jane L. Grogan
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 269-281.e4 (2019)
Summary: Myeloid-derived suppressor cells (MDSCs) are found in most cancer malignancies and support tumorigenesis by suppressing immunity and promoting tumor growth. Here we identify the bromodomain (BRD) of CBP/EP300 as a critical regulator of H3K27
Externí odkaz:
https://doaj.org/article/59bed4a4121e435abacf7f0ac7ad65fe
Autor:
J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, Wouter L. W. Hazenbos
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB
Externí odkaz:
https://doaj.org/article/3b9f916136964f4eb118797ed067be1e
Autor:
Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166438 (2016)
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require mo
Externí odkaz:
https://doaj.org/article/626380f9c1534821baa58955f830b641
Autor:
Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102695 (2014)
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases. The vertebrate RORs contain an ATP binding domain that deviates from
Externí odkaz:
https://doaj.org/article/080290e22e094a90849ffe90a71ec97c
Autor:
Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, Ivy A. Kekessie, Suzie J. Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S. Liu, Nataliya Popovych, Aaron T. Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A. Blake, Aimin Song, Steven T. Staben, Yingnan Zhang, David Arnott, Wayne J. Fairbrother, Scott A. Foster, Ingrid E. Wertz, Claudio Ciferri, Erin C. Dueber
Publikováno v:
Nature Chemical Biology. 19:55-63
Engineered destruction of target proteins by recruitment to the cell’s degradation machinery has emerged as a promising strategy in drug discovery. The majority of molecules that facilitate targeted degradation do so via a select number of ubiquiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cffe718a8e978d9932a3400ef0703fa
https://doi.org/10.1038/s41589-022-01218-w
https://doi.org/10.1038/s41589-022-01218-w
Autor:
Stephen B. Baylin, Hariharan Easwaran, Marie Classon, Patrick Trojer, David Arnott, Tommy K. Cheung, Catherine Wilson, Ioannis Kagiampakis, Benjamin R. Leadem
Contains Tables S1 and S2. Supplementary Table 1: List of PCR primers. Supplementary Table 2: Sensitivity of Breast Cancer Cell Lines to CPI-455 Cell Viability was measured following exposure to CPI-455 for 8 days.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4e7fae45bdbac8c44974efd5328bfc
https://doi.org/10.1158/0008-5472.22411056
https://doi.org/10.1158/0008-5472.22411056
Autor:
Stephen B. Baylin, Hariharan Easwaran, Marie Classon, Patrick Trojer, David Arnott, Tommy K. Cheung, Catherine Wilson, Ioannis Kagiampakis, Benjamin R. Leadem
KDM5i alone and in combination with DAC upregulates cancer hallmark & immunomodulatory pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce2a498fcfe253101ed1adae0e01c0b
https://doi.org/10.1158/0008-5472.22411074
https://doi.org/10.1158/0008-5472.22411074
Autor:
Stephen B. Baylin, Hariharan Easwaran, Marie Classon, Patrick Trojer, David Arnott, Tommy K. Cheung, Catherine Wilson, Ioannis Kagiampakis, Benjamin R. Leadem
Legends for Supplementary Figures and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bb63882753e89ef59be8b901dab75a
https://doi.org/10.1158/0008-5472.22411059
https://doi.org/10.1158/0008-5472.22411059
Autor:
Shijia Gao, David Arnott
Publikováno v:
Journal of Information Technology. 37:80-117
Theories of decision-making have long been important foundations for information systems research and much of the information system is concerned with information processing for decision-making. The discipline of behavioral economics provides the dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c20487e05e9cd995b1d12cb9174bed95
https://doi.org/10.1177/02683962211016000
https://doi.org/10.1177/02683962211016000