Zobrazeno 1 - 10
of 102
pro vyhledávání: '"DARIO GHERSI"'
Autor:
Pranita Atri, Ashu Shah, Gopalakrishnan Natarajan, Satyanarayana Rachagani, Sanchita Rauth, Koelina Ganguly, Joseph Carmicheal, Dario Ghersi, Jesse L. Cox, Lynette M. Smith, Maneesh Jain, Sushil Kumar, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real-w
Externí odkaz:
https://doaj.org/article/27698b79b7aa49419b969e281158a44b
Autor:
Ishwor Thapa, Dario Ghersi
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
Vector-borne infectious diseases cause more than 700,000 deaths a year and represent an increasing threat to public health worldwide. Strategies to mitigate the spread of vector-borne diseases can benefit from a thorough understanding of all mechanis
Externí odkaz:
https://doaj.org/article/e5ddc9b7c14c451ea8223d2d2910a71c
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Older people have difficulty controlling infection with common viruses such as influenza A virus (IAV), RNA virus which causes recurrent infections due to a high rate of genetic mutation, and Epstein Barr virus (EBV), DNA virus which persists in B ce
Externí odkaz:
https://doaj.org/article/d1cd9468b62f4ff5bddb18544f8b4baa
Autor:
Ramakanth Chirravuri-Venkata, Vi Dam, Rama Krishna Nimmakayala, Zahraa Wajih Alsafwani, Namita Bhyravbhatla, Imayavaramban Lakshmanan, Moorthy P. Ponnusamy, Sushil Kumar, Maneesh Jain, Dario Ghersi, Surinder K. Batra
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
MUC16/CA125 is one of the few oldest cancer biomarkers still used in current clinical practice. As mesothelium is an abundant source of MUC16 and a major contributor to stromal heterogeneity in PDAC, we investigated the regulation of MUC16 in tumor a
Externí odkaz:
https://doaj.org/article/67dc0525e46a477a889f4e265643784d
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010576 (2022)
Single-cell RNA-sequencing is an invaluable research tool that allows for the investigation of gene expression in heterogeneous cancer cell populations in ways that bulk RNA-seq cannot. However, normal (i.e., non tumor) cells in cancer samples have t
Externí odkaz:
https://doaj.org/article/80fd1041f4f1452cb8d5043f7e110277
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background With more T cell receptor sequence data becoming available, the need for bioinformatics approaches to predict T cell receptor specificity is even more pressing. Here we present SwarmTCR, a method that uses labeled sequence data to
Externí odkaz:
https://doaj.org/article/06c2843c05004ca49def50d2919dec52
Autor:
Jasmin Mischke, Sebastian Klein, Austin Seamann, Immo Prinz, Liisa Selin, Dario Ghersi, Markus Cornberg, Anke R.M. Kraft
Publikováno v:
Viruses, Vol 14, Iss 10, p 2293 (2022)
Immunological memory to a previously encountered pathogen can influence the outcome of a sequential infection, which is called heterologous immunity. Lymphocytic choriomeningitis virus (LCMV) immune mice develop a NP205-specific T cell response that
Externí odkaz:
https://doaj.org/article/25dabda49c694613b930194c59537936
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background Gene Ontology enrichment analysis provides an effective way to extract meaningful information from complex biological datasets. By identifying terms that are significantly overrepresented in a gene set, researchers can uncover bio
Externí odkaz:
https://doaj.org/article/975a347c269e4314bf363e77299d0c58
Autor:
Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio Clark, Dario Ghersi, Katherine Luzuriaga, Liisa K. Selin
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Recognition modes of individual T cell receptors (TCRs) are well studied, but factors driving the selection of TCR repertoires from primary through persistent human virus infections are less well understood. Using deep sequencing, we demonst
Externí odkaz:
https://doaj.org/article/2b7944df77564095993254270d153052
Autor:
Larisa Kamga, Anna Gil, Inyoung Song, Robin Brody, Dario Ghersi, Nuray Aslan, Lawrence J Stern, Liisa K Selin, Katherine Luzuriaga
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008122 (2019)
The T cell receptor (TCR) repertoire is an essential component of the CD8 T-cell immune response. Here, we seek to investigate factors that drive selection of TCR repertoires specific to the HLA-A2-restricted immunodominant epitope BRLF1109-117 (YVLD
Externí odkaz:
https://doaj.org/article/703140853030433a8ed9e6c28be195a4