Zobrazeno 1 - 10
of 2 698
pro vyhledávání: '"DARIO C"'
Autor:
Katarzyna Bialkowska, Lamyae El Khalki, Priyanka S. Rana, Wei Wang, Daniel J. Lindner, Yvonne Parker, Lucia R. Languino, Dario C. Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward F. Plow
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners, Kindlin-2 intercalates into numerous signaling pathways and cytoskeletal nodes. A specific
Externí odkaz:
https://doaj.org/article/5573cad98044439ab462d68666ca541d
Autor:
Cecilia E. Verrillo, Fabio Quaglia, Christopher D. Shields, Stephen Lin, Andrew V. Kossenkov, Hsin‐Yao Tang, David Speicher, Nicole M. Naranjo, Anna Testa, William K. Kelly, Qin Liu, Benjamin Leiby, Luca Musante, Khalid Sossey‐Alaoui, Navneet Dogra, Tzu‐Yi Chen, Dario C. Altieri, Lucia R. Languino
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 8, Pp n/a-n/a (2024)
Abstract It is known that small extracellular vesicles (sEVs) are released from cancer cells and contribute to cancer progression via crosstalk with recipient cells. We have previously reported that sEVs expressing the αVβ3 integrin, a protein upre
Externí odkaz:
https://doaj.org/article/04359d9772ad413f94e97e0367c5aad3
Autor:
João C.G. Figueiredo, Daniel Negreiros, Letícia Ramos, Dario C. Paiva, Yumi Oki, Wénita S. Justino, Rubens M. Santos, Ramiro Aguilar, Yule R. F. Nunes, G. Wilson Fernandes
Publikováno v:
Nature Conservation Research: Заповедная наука, Vol 9, Iss 1, Pp 58-71 (2024)
The most important condition of ecological restoration is the identification of reference ecosystems, which function as a guide for assertive practice with which biological integrity and ecosystem structure and function can be compared. For restorati
Externí odkaz:
https://doaj.org/article/4ada4354fb02432cb50fcc5124d7df1f
Autor:
Giovanni Cicceri, Dario C. Guastella, Giuseppe Sutera, Francesco Cancelliere, Mario Vitti, Giovanni Randazzo, Salvatore DiStefano, Giovanni Muscato
Publikováno v:
IEEE Access, Vol 11, Pp 134421-134445 (2023)
Nestled at the confluence of nature grandeur and human civilization, beaches command an influential presence that resonates throughout the environment, society, and culture. However, climate change and pollution overhang the beach health and need to
Externí odkaz:
https://doaj.org/article/c45788a49e7c4833a6ac224672a77d36
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 117-126 (2022)
Mitochondria are key tumor drivers, but their suitability as a therapeutic target is unknown. Here, we report on the preclinical characterization of Gamitrinib (GA mitochondrial matrix inhibitor), a first-in-class anticancer agent that couples the He
Externí odkaz:
https://doaj.org/article/323440b459744844bcf3002c13b30f4e
Autor:
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 173-185 (2022)
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of ITGB6 (encoding th
Externí odkaz:
https://doaj.org/article/72b471d60c604bb597ae18142f20f9e6
Autor:
Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter McCue, Andrew V. Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, Lucia R. Languino
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Androgen deprivation therapies aimed to target prostate cancer (PrCa) are only partially successful given the occurrence of neuroendocrine PrCa (NEPrCa), a highly aggressive and highly metastatic form of PrCa, for which there is no effective
Externí odkaz:
https://doaj.org/article/3eeb18d3b89f4f6090553922e8d4285e
Autor:
Irene Bertolini, Michela Perego, Yulia Nefedova, Cindy Lin, Andrew Milcarek, Peter Vogel, Jagadish C. Ghosh, Andrew V. Kossenkov, Dario C. Altieri
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
The origin of breast cancer, whether primary or recurrent, is unknown. Here, we show that invasive breast cancer cells exposed to hypoxia release small extracellular vesicles (sEVs) that disrupt the differentiation of normal mammary epithelia, expand
Externí odkaz:
https://doaj.org/article/4fe636aeb4384412a043da382ccdea21
Autor:
Salvatore Livatino, Dario C. Guastella, Giovanni Muscato, Vincenzo Rinaldi, Luciano Cantelli, Carmelo D. Melita, Alessandro Caniglia, Riccardo Mazza, Gianluca Padula
Publikováno v:
IEEE Access, Vol 9, Pp 25795-25808 (2021)
Mobile robotic systems have evolved to include sensors capable of truthfully describing robot status and operating environment as accurately and reliably as never before. This possibility is challenged by effective sensor data exploitation, because o
Externí odkaz:
https://doaj.org/article/32d71412b6d74dcab45c856ec3775672
Autor:
Andrew V. Kossenkov, Andrew Milcarek, Faiyaz Notta, Gun-Ho Jang, Julie M. Wilson, Steven Gallinger, Daniel Cui Zhou, Li Ding, Jagadish C. Ghosh, Michela Perego, Annamaria Morotti, Marco Locatelli, Marie E. Robert, Valentina Vaira, Dario C. Altieri
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Changes in metabolism are a hallmark of cancer, but molecular signatures of altered bioenergetics to aid in clinical decision-making do not currently exist. We recently identified a group of human tumors with constitutively reduced expression of the
Externí odkaz:
https://doaj.org/article/23ae9a0e7d374dc69340f7e02d36417c