Výsledky vyhledávání - "DAOZHONG JIN"

NMDA Receptors at Primary Afferent–Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain

Autor: Yuying Huang, Hong Chen, Daozhong Jin, Shao-Rui Chen, Hui-Lin Pan

Publikováno v: The Journal of Neuroscience. 43:3933-3948

The spinal dorsal horn contains vesicular glutamate transporter-2 (VGluT2)-expressing excitatory neurons and vesicular GABA transporter (VGAT)-expressing inhibitory neurons, which normally have different roles in nociceptive transmission. Spinal glut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d765a6413708f982831e91c623a8b9e0
https://doi.org/10.1523/jneurosci.0183-23.2023

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HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing α2δ-1 Expression and Associated NMDA Receptor Activity

Autor: Jixiang Zhang, Shao-Rui Chen, Meng-Hua Zhou, Daozhong Jin, Hong Chen, Li Wang, Ronald A. DePinho, Hui-Lin Pan

Publikováno v: J Neurosci

α2δ-1 (encoded by theCacna2d1gene) is a newly discovered NMDA receptor-interacting protein and is the therapeutic target of gabapentinoids (e.g., gabapentin and pregabalin) frequently used for treating patients with neuropathic pain. Nerve injury c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26980e7277e10589488290ced53d4c2b
https://doi.org/10.1523/jneurosci.0735-22.2022

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Theta-Burst Stimulation of Primary Afferents Drives Long-Term Potentiation in the Spinal Cord and Persistent Pain via α2δ-1-Bound NMDA Receptors

Autor: Yuying Huang, Shao-Rui Chen, Hong Chen, Jing-Jing Zhou, Daozhong Jin, Hui-Lin Pan

Publikováno v: J Neurosci

Long-term potentiation (LTP) and long-term depression (LTD) in the spinal dorsal horn reflect activity-dependent synaptic plasticity and central sensitization in chronic pain. Tetanic high-frequency stimulation is commonly used to induce LTP in the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ef178f05dcb6611eafea087a82369f
https://doi.org/10.1523/jneurosci.1968-21.2021

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α2δ-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy

Autor: Shao Rui Chen, Hong Chen, Daozhong Jin, Guang Fen Zhang, Yuying Huang, Hui Lin Pan

Publikováno v: J Neurosci

Systemic treatment with resiniferatoxin (RTX) induces small-fiber sensory neuropathy by damaging TRPV1-expressing primary sensory neurons and causes distinct thermal sensory impairment and tactile allodynia, which resemble the unique clinical feature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d40851e47a70433d3aeac56c4b276cb
https://doi.org/10.1523/jneurosci.0303-21.2021

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Akademický článek

mGluR5 from Primary Sensory Neurons Promotes Opioid-Induced Hyperalgesia and Tolerance by Interacting with and Potentiating Synaptic NMDA Receptors.

Autor: Daozhong Jin, Hong Chen, Meng-Hua Zhou, Shao-Rui Chen, Hui-Lin Pan

Publikováno v: Journal of Neuroscience; 8/2/2023, Vol. 43 Issue 31, p5593-5607, 15p

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α2δ-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens

Autor: Daozhong Jin, Hong Chen, Shao‐Rui Chen, Hui‐Lin Pan

Publikováno v: Journal of neurochemistryREFERENCES.

Glutamate NMDA receptors (NMDARs) in the nucleus accumbens (NAc) are critically involved in drug dependence and reward. α2δ-1 is a newly discovered NMDAR-interacting protein that promotes synaptic trafficking of NMDARs independently of its conventi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15171ee7eca3bae9d88e28c5e6dc397
https://pubmed.ncbi.nlm.nih.gov/36222452

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δ-Opioid receptors in primary sensory neurons tonically restrain nociceptive input in chronic pain but do not enhance morphine analgesic tolerance

Autor: Daozhong Jin, Hong Chen, Yuying Huang, Shao-Rui Chen, Hui-Lin Pan

Publikováno v: Neuropharmacology. 217

δ-Opioid receptors (DORs, encoded by the Oprd1 gene) are expressed throughout the peripheral and central nervous system, and DOR stimulation reduces nociception. Previous studies suggest that DORs promote the development of analgesic tolerance of μ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a515db076351827095b2d700f037d84d
https://pubmed.ncbi.nlm.nih.gov/35917874

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