BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris

Autor: Alexis, Andrew, Del Rosso, James Q., Desai, Seemal R., Downie, Jeanine B., Draelos, Zoe Diana, Feser, Christina, Forconi, Rion, Fowler Jr., Joseph F., Gold, Michael, Kaufman-Janette, Joely, Lain, Edward, Lee, Mark, Ling, Mark, Shamban, Ava T., Werschler, WM. Philip, Daniels, Annamarie

Background and objectives: Acne vulgaris is a highly prevalent and multifactorial skin disorder that can adversely impact health-related quality of life. Factors that contribute to the pathogenesis of acne include pilosebaceous proliferation of proin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db72a5dfd88258ba24fcb5624e7b4cce
https://europepmc.org/articles/PMC6303111/

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BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris.

Autor: Alexis A; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Del Rosso JQ; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Desai SR; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Downie JB; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Draelos ZD; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Feser C; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Forconi R; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Fowler JF Jr; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Gold M; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Kaufman-Janette J; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Lain E; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Lee M; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Ling M; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Shamban AT; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Werschler WP; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California., Daniels A; Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.; Dr. Del Rosso is with JDR Dermatology Research in Las Vegas, Nevada.; Dr. Desai is with ACRC Trials/Innovative Dermatology in Plano, Texas.; Dr. Downie is with Image Dermatology in Montclair, New Jersey.; Dr. Draelos is with Dermatology Consulting Services in High Point, North Carolina. Drs. Feser and Forconi are with International Clinical Research in Sanford, Florida.; Dr. Fowler is with DS Research in Louisville, Kentucky.; Dr. Gold is with the Tennessee Clinical Research Center in Nashville, Tennessee.; Dr. Kaufman-Janette is with the Skin Research Institute in Coral Gables, Florida.; Dr. Lain is with the Austin Institute for Clinical Research in Heatherwilde, Texas.; Dr. Lee is with Progressive Clinical Research in San Antonio, Texas.; Dr. Ling is with MedaPhase in Newnan, Georgia.; Dr. Shamban is with Medical and Cosmetic Dermatology in Santa Monica, California.; Dr. Werschler is with Premier Clinical Research in Spokane, Washington. Ms. Daniels is with BioPharmX in Menlo Park, California.

Publikováno v: The Journal of clinical and aesthetic dermatology [J Clin Aesthet Dermatol] 2018 Nov; Vol. 11 (11), pp. 25-35. Date of Electronic Publication: 2018 Nov 01.