Zobrazeno 1 - 10
of 245
pro vyhledávání: '"DANIEL STONE"'
Autor:
Martine Aubert, Anoria K. Haick, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Meei-Li Huang, Ollivier Hyrien, Daniel Stone, Keith R. Jerome
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Anti-HSV therapies are only suppressive because they do not eliminate latent HSV present in ganglionic neurons, the source of recurrent disease. We have developed a potentially curative approach against HSV infection, based on gene editing u
Externí odkaz:
https://doaj.org/article/9723e7ae8e8b4b0fabbaa81b521d59db
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101261- (2024)
Externí odkaz:
https://doaj.org/article/acf4fce5175c45888e0f5301bfc3922b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101105- (2023)
Externí odkaz:
https://doaj.org/article/b036c43527ea48a0881a4363bcc9f5ae
Autor:
Rossana Colón-Thillet, Daniel Stone, Michelle A. Loprieno, Lindsay Klouser, Pavitra Roychoudhury, Tracy K. Santo, Hong Xie, Laurence Stensland, Sarah L. Upham, Gregory Pepper, Meei-Li Huang, Martine Aubert, Keith R. Jerome
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Hepatitis B virus (HBV) is a pathogen of major public health importance that is largely incurable once a chronic infection is established. Only humans and great apes are fully permissive to HBV infection, and this species restriction has imp
Externí odkaz:
https://doaj.org/article/dbccde519db843748d5b366653d72100
Autor:
Daniel Stone, Nadja Meumann, Anne-Sophie Kuhlmann, Christopher W. Peterson, Hong Xie, Pavitra Roychoudhury, Michelle A. Loprieno, Xuan-Khang Vu, Daniel E. Strongin, Elizabeth J. Kenkel, Anoria Haick, Laurence Stensland, Willimark M. Obenza, Jacob Parrott, Veronica Nelson, Robert D. Murnane, Meei-Li Huang, Martine Aubert, Hans-Peter Kiem, Hildegard Büning, Keith R. Jerome
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0009-e0009 (2023)
Background and Aims:. Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered capsids have
Externí odkaz:
https://doaj.org/article/1d40d622a45b4cc6aa011947303c4dea
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Gene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and persist is a promising approach for the next generation of antiviral therapies. Recombinant adeno-associated viruses (AAV) are one of the leading vector
Externí odkaz:
https://doaj.org/article/43fb5c0df8f748ddbc43d0afc16f5360
Autor:
Daniel Stone, Kelly R. Long, Michelle A. Loprieno, Harshana S. De Silva Feelixge, Elizabeth J. Kenkel, R. Matt Liley, Stephen Rapp, Pavitra Roychoudhury, Thuy Nguyen, Laurence Stensland, Rossana Colón-Thillet, Lindsay M. Klouser, Nicholas D. Weber, Connie Le, Jessica Wagoner, Erin A. Goecker, Alvason Zhenhua Li, Karsten Eichholz, Lawrence Corey, D. Lorne Tyrrell, Alexander L. Greninger, Meei-Li Huang, Stephen J. Polyak, Martine Aubert, John E. Sagartz, Keith R. Jerome
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 258-275 (2021)
Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment approaches are needed because current treatments do not target covalently closed circular DNA (cccDNA), the template for HBV replication, and rarely clear the v
Externí odkaz:
https://doaj.org/article/50136f1751074d8594ac5811c80e88ea
Autor:
Martine Aubert, Daniel E. Strongin, Pavitra Roychoudhury, Michelle A. Loprieno, Anoria K. Haick, Lindsay M. Klouser, Laurence Stensland, Meei-Li Huang, Negar Makhsous, Alexander Tait, Harshana S. De Silva Feelixge, Roman Galetto, Philippe Duchateau, Alexander L. Greninger, Daniel Stone, Keith R. Jerome
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract We evaluate gene editing of HSV in a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as a potentially curative approach to treat latent HSV infection. Here we show that AAV-delivered meganucleases, b
Externí odkaz:
https://doaj.org/article/f4d037a80a34400ba2411e4046361719
Publikováno v:
Water Research X, Vol 9, Iss , Pp 100067- (2020)
Fecal indicator bacteria (FIB) are typically used to monitor microbial water quality but are poor representatives of viruses due to different environmental fate. Viral fecal indicators have been proposed as alternatives to FIB; however, data evaluati
Externí odkaz:
https://doaj.org/article/80178e5cfa394d8d90085274f61f1f87
Publikováno v:
Environment International, Vol 136, Iss , Pp - (2020)
Wastewater treatment plants are typically monitored using fecal indicator bacteria to ensure adequate microbial water quality of the treated effluent. Fecal indicator bacteria exhibit poor correlation with virus fate in the environment, including dur
Externí odkaz:
https://doaj.org/article/f54aa1399fe648c6b4e901b0f518f501