Zobrazeno 1 - 10
of 460
pro vyhledávání: '"DANIEL J. DRUCKER"'
Autor:
Leticia Forny Germano, Jacqueline A. Koehler, Laurie L. Baggio, Fiona Cui, Chi Kin Wong, Nikolaj Rittig, Xiemin Cao, Dianne Matthews, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102019- (2024)
Objective: The development of glucagon-like peptide-1 receptor (GLP-1R) agonists for the treatment of type 2 diabetes and obesity has been accompanied by evidence for anti-inflammatory and cytoprotective actions in the heart, blood vessels, kidney, a
Externí odkaz:
https://doaj.org/article/251c6b672668429ebb6e64cd03609235
Autor:
William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger
Publikováno v:
Molecular Metabolism, Vol 91, Iss , Pp 102073- (2025)
Objective: Glucagon is a crucial regulator of glucose and lipid metabolism as well as whole-body energy balance. Thus, modulation of glucagon receptor (GCGR) activity in the context of single-molecule multi-receptor co-agonists has become an emerging
Externí odkaz:
https://doaj.org/article/a43fcb007fdf44d8b7126f4df420df06
Autor:
Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E.V. Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101924- (2024)
Objectives: Gut microbiota increases energy availability through fermentation of dietary fibers to short-chain fatty acids in conventionally raised mice. Energy deficiency in germ-free (GF) mice increases glucagon-like peptide-1 (GLP-1) levels, which
Externí odkaz:
https://doaj.org/article/263a379437f5472790b2cc60cb953f8c
Autor:
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101915- (2024)
Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight and glucose c
Externí odkaz:
https://doaj.org/article/4df457ac59ce49e8af09680efdd590e2
Autor:
Thao D.V. Le, Payam Fathi, Amanda B. Watters, Blair J. Ellis, Gai-Linn K. Besing, Nadejda Bozadjieva-Kramer, Misty B. Perez, Andrew I. Sullivan, Jesse P. Rose, Laurie L. Baggio, Jacqueline Koehler, Jennifer L. Brown, Michelle B. Bales, Kaitlyn G. Nwaba, Jonathan E. Campbell, Daniel J. Drucker, Matthew J. Potthoff, Randy J. Seeley, Julio E. Ayala
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101718- (2023)
Objective: Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading us to investigate mechanisms engaged by the GLP-1RA liraglutide to increa
Externí odkaz:
https://doaj.org/article/d72c33cca2fa47dca8da218c427827be
Autor:
Maegan E. Chen, Setareh Malekian Naeini, Arjuna Srikrishnaraj, Daniel J. Drucker, Zivit Fesler, Patricia L. Brubaker
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1829-1842 (2022)
Background & Aims: Leucine-rich repeat-containing G-protein–coupled receptor-5 (Lgr5)+/olfactomedin-4 (Olfm4)+ intestinal stem cells (ISCs) in the crypt base are crucial for homeostatic maintenance of the epithelium. The gut hormone, glucagon-like
Externí odkaz:
https://doaj.org/article/7903d4f158514e2ca82d59830f968335
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101641- (2022)
Objectives: Glucagon-like peptide-1 receptor (GLP-1R) agonists reduce the rates of major cardiovascular events, including myocardial infarction in people with type 2 diabetes, and decrease infarct size while preserving ventricular function in preclin
Externí odkaz:
https://doaj.org/article/80c33a84e307409e8246f26cdf1c83ad
Autor:
Tina Zimmermann, Leo Thomas, Tamara Baader-Pagler, Peter Haebel, Eric Simon, Wolfgang Reindl, Besnik Bajrami, Wolfgang Rist, Ingo Uphues, Daniel J. Drucker, Holger Klein, Rakesh Santhanam, Dieter Hamprecht, Heike Neubauer, Robert Augustin
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101633- (2022)
Objective: Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse pharmaceutical interventions. Oxyntomodulin is a gut peptide that activates the glucagon re
Externí odkaz:
https://doaj.org/article/17b23caf79c94158be502e566134d4c5
Autor:
Gemma Pujadas, Laurie L. Baggio, Kiran Deep Kaur, Brent A. McLean, Xiemin Cao, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101586- (2022)
Objective: The gut hormone glucose-dependent insulinotropic polypeptide (GIP) stimulates beta cell function and improves glycemia through its incretin actions. GIP also regulates endothelial function and suppresses adipose tissue inflammation through
Externí odkaz:
https://doaj.org/article/7e70eb06308240b68752d72f802653ba
Autor:
Laurie L. Baggio, Elodie M. Varin, Jacqueline A. Koehler, Xiemin Cao, Yuliya Lokhnygina, Susanna R. Stevens, Rury R. Holman, Daniel J. Drucker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain. Here the authors study whether DPP4 inhibition controls sDPP4 and inflammat
Externí odkaz:
https://doaj.org/article/cfbe57d96821439588f72940834dce14