Optimizing drug discovery by Investigative Toxicology: Current and future trends

Autor: Beilmann, Mario, Boonen, Harrie, Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Newham, Peter, Oinonen, Teija, Pognan, Francois, Roth, Adrian, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J, Birk, Barbara, Boyer, Scott, Caloni, Francesca, Chen, Alice E, Corvi, Raffaella, Cronin, Mark T D, Daneshian, Mardas, Ewart, Lorna C, Fitzgerald, Rex E, Hamilton, Geraldine A, Hartung, Thomas, Kangas, Joshua D, Kramer, Nynke I, Leist, Marcel, Marx, Uwe, Polak, Sebastian, Rovida, Costanza, Testai, Emanuela, Van der Water, Bob, Vulto, Paul, Steger-Hartmann, Thomas, One Health Toxicologie, dIRAS RA-1

Publikováno v: ALTEX : Alternatives to Animal Experimentation, 36(2), 289-313
Altex, 36(2), 289. Springer International Publishing AG
ALTEX
ALTEX : Alternatives to Animal Experimentation

Investigative Toxicology describes the de-risking and mechanistic elucidation of toxicities, supporting early safety decisions in the pharmaceutical industry. Recently, Investigative Toxicology has contributed to a shift in pharmaceutical toxicology,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb64dc6fe72ce1d9d6a38f319e0ce082
http://hdl.handle.net/1887/67901

Recommendation on test readiness criteria for new approach methods in toxicology : Exemplified for developmental neurotoxicity

Autor: Bal-Price, Anna K., Hogberg, Helena T., Crofton, Kevin M., Daneshian, Mardas, FitzGerald, Rex E., Fritsche, Ellen, Heinonen, Tuula, Klima, Stefanie, Waldmann, Tanja, Leist, Marcel

Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The field of developmental neurotoxicity (DNT) test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______715::5516a76f051dd840333ed007c2a86255

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

Autor: Bal-Price, Anna, Hogberg, Helena T, Crofton, Kevin M, Daneshian, Mardas, FitzGerald, Rex E, Fritsche, Ellen, Heinonen, Tuula, Hougaard Bennekou, Susanne, Klima, Stefanie, Piersma, Aldert H, Sachana, Magdalini, Shafer, Timothy J, Terron, Andrea, Monnet-Tschudi, Florianne, Viviani, Barbara, Waldmann, Tanja, Westerink, Remco H S, Wilks, Martin F, Witters, Hilda, Zurich, Marie-Gabrielle, Leist, Marcel, One Health Toxicologie, dIRAS RA-1, Sub RIVM

Publikováno v: Altex, 36(3). Springer International Publishing AG

Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The field of developmental neurotoxicity (DNT) test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7174bdb9b4117d5ae9173910eb144e93
https://doi.org/10.14573/altex.1904112

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Autor: Marx, Uwe, Andersson, Tommy B, Bahinski, Anthony, Beilmann, Mario, Beken, Sonja, Cassee, Flemming R, Cirit, Murat, Daneshian, Mardas, Fitzpatrick, Susan, Frey, Olivier, Gaertner, Claudia, Giese, Christoph, Griffith, Linda, Hartung, Thomas, Heringa, Minne B, Hoeng, Julia, de Jong, Wim H, Kojima, Hajime, Kuehnl, Jochen, Leist, Marcel, Luch, Andreas, Maschmeyer, Ilka, Sakharov, Dmitry, Sips, Adrienne J A M, Steger-Hartmann, Thomas, Tagle, Danilo A, Tonevitsky, Alexander, Tralau, Tewes, Tsyb, Sergej, van de Stolpe, Anja, Vandebriel, Rob, Vulto, Paul, Wang, Jufeng, Wiest, Joachim, Rodenburg, Marleen, Roth, Adrian, LS IRAS EEPI Inhalatie Toxicologie, dIRAS RA-2

Publikováno v: BASE-Bielefeld Academic Search Engine
Altex, 33(3), 272. Springer International Publishing AG
ALTEX
ALTEX, 33 (3)

The recent advent of microphysiological systems – microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro – promises to enable a global paradigm shift in drug development. An extraordin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70584853f182e2248471076f5eae4c25
https://dspace.library.uu.nl/handle/1874/344409

Integrated Testing Strategies (ITS) for safety assessment

Autor: Rovida, Costanza, Alepee, Nathalie, Api, Anne M., Basketter, David A., Bois, Frederic Y., Caloni, Francesca, Corsini, Emanuela, Daneshian, Mardas, Eskes, Chantra, Ezendam, Janine, Fuchs, Horst, Hayden, Patrick, Hegele-Hartung, Christa, Hoffmann, Sebastian, Hubesch, Bruno, Jacobs, Miriam N., Jaworska, Joanna, Kleensang, Andre, Kleinstreuer, Nicole, Lalko, Jon, Landsiedel, Robert, Lebreux, Frederic, Luechtefeld, Thomas, Locatelli, Monica, Mehling, Annette, Natsch, Andreas, Pitchford, Jonathan W., Prater, Donald, Prieto, Pilar, Schepky, Andreas, Gerrit Schüürmann, Smirnova, Lena, Toole, Colleen, Vliet, Erwin, Weisensee, Dirk, Hartung, Thomas

Publikováno v: ALTEX-Alternatives to Animal Experimentations
ALTEX-Alternatives to Animal Experimentations, 2015, 32 (1), pp.25-40. ⟨10.14573/altex.1411011⟩
ResearcherID

International audience; Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::42c943d875ffaa9ee1c4c987d2c55d38
https://hal-polytechnique.archives-ouvertes.fr/hal-01127740/document