Zobrazeno 1 - 10
of 26
pro vyhledávání: '"DAMPs, Danger Associated Molecular Patterns"'
Autor:
Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf60046ceb32698b7a7ea7c3674b44
http://www.sciencedirect.com/science/article/pii/S2211383521001775
http://www.sciencedirect.com/science/article/pii/S2211383521001775
Publikováno v:
The Journal of Biological Chemistry
The complement cascade is a key component of the innate immune system that is rapidly recruited through a cascade of enzymatic reactions to enable the recognition and clearance of pathogens and promote tissue repair. Despite its well-understood role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681edf95e728cddfccd1ca259ec920eb
http://europepmc.org/articles/PMC8446806
http://europepmc.org/articles/PMC8446806
Autor:
George Frimpong Boafo, Zhongjian Chen, Marwa Ahmed Sallam, Qingqing Xiao, Makhloufi Zoulikha, Wei He
Publikováno v:
Acta Pharmaceutica Sinica. B
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify the expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9513250ae8817b12d84c4264ed5c97
https://pubmed.ncbi.nlm.nih.gov/34401226
https://pubmed.ncbi.nlm.nih.gov/34401226
Publikováno v:
Seminars in Cell & Developmental Biology
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628bb448c2d6de5b9d7755cdadd35794
http://europepmc.org/articles/PMC7448748
http://europepmc.org/articles/PMC7448748
Autor:
Rebecca C. Coll, Tamara L Allen, Mark A. Febbraio, Helene L. Kammoun, S. Barre, Graeme I. Lancaster, Darren C. Henstridge, Mark S. Butler, Saskia Reibe, Mark E. Cooper, Luke A. J. O'Neill, D. R. Laybutt, Jeng Yie Chan, Avril A. B. Robertson, Lena Cron, Mohammed Bensellam
Publikováno v:
Molecular Metabolism, Vol 10, Iss, Pp 66-73 (2018)
Molecular Metabolism
Molecular Metabolism
Objectives Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure in T2D. Specific targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8a68246153e72d6a35820ff8e2849d
https://doi.org/10.1016/j.molmet.2018.02.001
https://doi.org/10.1016/j.molmet.2018.02.001
Autor:
Wen-Yi Chang, Yung-Fong Tsai, Chun-Yu Chen, Chih-Chuang Liaw, Tsong-Long Hwang, Chuan-Hui Yang
Publikováno v:
Redox Biology, Vol 11, Iss, Pp 263-274 (2017)
Redox Biology
Redox Biology
The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome contains Nod-like receptors, a subclass of pattern recognition receptors, suggesting that this complex has a prominent role in host defenses. Various structurally diverse stimulators activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06f83fe436ec59015422cdf4d6291e4
http://www.sciencedirect.com/science/article/pii/S2213231716303500
http://www.sciencedirect.com/science/article/pii/S2213231716303500
Autor:
Lisardo Boscá, Carmen Delgado, Rafael I. Jaén, Almudena Val-Blasco, María Fernández-Velasco, Jose Lopez-Sendon, Marta Gil-Fernández, Patricia Prieto, Tarik Smani
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
JACC: Basic to Translational Science
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
instname
JACC: Basic to Translational Science
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Central Illustration
Highlights • The present review recapitulates relevant findings related to the role of the receptors of the innate immune system (TLRs and NLRs) in the progression of the most prevalent CVDs. • TLRs and NLRs play a key r
Highlights • The present review recapitulates relevant findings related to the role of the receptors of the innate immune system (TLRs and NLRs) in the progression of the most prevalent CVDs. • TLRs and NLRs play a key r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1d6d393016f9f807d1f1f67e4a58c1
http://hdl.handle.net/10261/222223
http://hdl.handle.net/10261/222223
Publikováno v:
Biochemical Pharmacology
Graphical abstract
On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million people
On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million people
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f360aa8ab7f316d50cacb98cc206343f
http://hdl.handle.net/2108/256570
http://hdl.handle.net/2108/256570
Autor:
Giulio Maria Pasinetti, Kunal Kumar, Robert J. De Vita, Maria Sebastian-Valverde, Al Rahim, Roberto Sanchez, Henry Wu
Publikováno v:
The Journal of Biological Chemistry
Inflammasomes are macromolecular complexes involved in the host response to external and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a central role in several human conditions such as autoimmune diseases, type-2 diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78c2f0f37f5734134e2bfbe5fb0946d
https://doi.org/10.1016/j.jbc.2021.100597
https://doi.org/10.1016/j.jbc.2021.100597
Autor:
Jia-Xi Duan, Wen-Jing Zhong, Jin-Tong Yang, Yong Zhou, Tian Liu, Qing Li, Jian-Bing Xiong, Chen-Yu Zhang, Cha-Xiang Guan, Xin-Xin Guan, Hui-Hui Yang
Publikováno v:
International Immunopharmacology
Highlights • NLRP3 inflammasome inhibition reduces TREM-1 expression in the lungs of mice with ALI. • Activation of NLRP3 inflammasome up-regulates TREM-1 expression in murine macrophages via HMGB1 and IL-18. • NLRP3 inflammasome activation ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195558f276d9e40c559d55a7eb77368a
https://doi.org/10.1016/j.intimp.2020.107045
https://doi.org/10.1016/j.intimp.2020.107045