Zobrazeno 1 - 10
of 42
pro vyhledávání: '"DAMIAN GROBELNY"'
Autor:
David K. Chalmers, Jason H. Chaplin, Tina C. Lavranos, Bernard L. Flynn, Annabell F. Leske, Dharam Paul, Gurmit S. Gill, Damian Grobelny, Ernest Hamel, Edmund Kostewicz, Julia Morizzi, M. Katherine Jung, David M. Shackleford, Gabriel Kremmidiotis, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 54:6014-6027
A structure-activity relationship (SAR) guided design of novel tubulin polymerization inhibitors has resulted in a series of benzo[b]furans with exceptional potency toward cancer cells and activated endothelial cells. The potency of early lead compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50248d4cd2d0cae01b413445e930e2a
https://doi.org/10.1021/jm200454y
https://doi.org/10.1021/jm200454y
Publikováno v:
International Journal of Peptide and Protein Research. 32:292-297
Nα-(Phenethylphosphono)-l-alanyl-l-proline 1, a potent inhibitor of angiotensin converting enzyme, exhibits two 31P n.m.r. resonances (intensity ratio one to one), which exchange with a constant (k1) of about 1 s−1 and a free energy of activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cd31b3b428a50737b89b3c9f5b71e9
https://doi.org/10.1111/j.1399-3011.1988.tb01263.x
https://doi.org/10.1111/j.1399-3011.1988.tb01263.x
Publikováno v:
The Journal of Organic Chemistry. 73:1131-1134
A convenient method for the synthesis of 2-bromo-3-aroyl-benzo[b]furans from readily accessible precursors has been developed. The 2-bromo group has been employed as a versatile synthetic handle in both palladium-mediated couplings and direct nucleop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a655e9227a7d74caa314cb3f2c47e1a
https://doi.org/10.1021/jo701656z
https://doi.org/10.1021/jo701656z
Publikováno v:
Molecular Simulation. 28:827-843
NMR spectroscopy techniques have been used to determine the conformation of DG35-VIII in DMSO, acetone, and methanol. COSY and Heteronuclear Correlation experiments were used to confirm the proton spectral assignments. NOESY experiments were used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8b886a4e64ca9d107df0efd52257df
https://doi.org/10.1080/0892702021000002511
https://doi.org/10.1080/0892702021000002511
Autor:
Daniel E. Levy, France Lapierre, Weisheng Liang, Wenqing Ye, Christopher W. Lange, Xiaoyuan Li, Damian Grobelny, Marie Casabonne, David Tyrrell, Kevin Holme, Alex Nadzan, Richard E. Galardy
Publikováno v:
Journal of Medicinal Chemistry. 41:199-223
Modifications around the dipeptide-mimetic core of a hydroxamic acid based matrix metalloproteinase inhibitor were studied. These variations incorporated a variety of natural, unnatural, and synthetic amino acids in addition to modifications of the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3305083e8dd9cc67803fbd243001f88
https://doi.org/10.1021/jm970494j
https://doi.org/10.1021/jm970494j
Antiviral Activity of DG-35-VIII, a Potent Inhibitor of the Protease of Human Immunodeficiency Virus
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:99-106
The protease of human immunodeficiency virus (HIV) is an important target for antiretroviral drug therapy. The synthesis and in vitro antiviral activity of a novel protease inhibitor, DG-35-VIII, which contains an hydroxyethylhydrazide core unit, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c849dd1e4da63e0fcebb5ec5d26524d3
https://doi.org/10.1177/095632029700800203
https://doi.org/10.1177/095632029700800203
Autor:
RICHARD E. GALARDY, MARIE E. CASSABONNE, CARLANNE GIESE, JAMES H. GILBERT, FRANCE LAPIERRE, HENRY LOPEZ, MARY E. SCHAEFER, ROBERT STACK, MICHAEL SULLIVAN, BRENT SUMMERS, ROB TRESSLER, DAVE TYRRELL, JENNIFER WEE, SCOTT D. ALLEN, JOHN J. CASTELLOT, JOHN P. BARLETTA, GREGORY S. SCHULTZ, LEONARDO A. FERNANDEZ, SUSAN FISHER, TIAN-YI CUI, HARALD G. FOELLMER, DAMIAN GROBELNY, WALTER M. HOLLERAN
Publikováno v:
Annals of the New York Academy of Sciences. 732:315-323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00901a7a3e673c594adf15544cec8d58
https://doi.org/10.1111/j.1749-6632.1994.tb24746.x
https://doi.org/10.1111/j.1749-6632.1994.tb24746.x
Autor:
Clifford Librach, King Chiu, Susan J. Fisher, Damian Grobelny, Marilyn L. Fitzgerald, Caroline H. Damsky, Richard E. Galardy, Zena Werb, Nanci M. Corwin, Ruth A. Esteves
Publikováno v:
The Journal of Cell Biology
The specialized interaction between embryonic and maternal tissues is unique to mammalian development. This interaction begins with invasion of the uterus by the first differentiated embryonic cells, the trophoblasts, and culminates in formation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc4995c5d4277e4d0d5b4e48a652786
http://europepmc.org/articles/PMC2288933
http://europepmc.org/articles/PMC2288933
Publikováno v:
ChemInform. 39
A convenient method for the synthesis of 2-bromo-3-aroyl-benzo[b]furans from readily accessible precursors has been developed. The 2-bromo group has been employed as a versatile synthetic handle in both palladium-mediated couplings and direct nucleop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d82ff9f9e107fac7d12550327fc5864
https://doi.org/10.1002/chin.200823104
https://doi.org/10.1002/chin.200823104
Publikováno v:
Biochemistry. 31(31)
The hydroxamic acid HONHCOCH2CH(i-Bu)CO-L-Trp-NHMe, isomer 6A (GM 6001), inhibits human skin fibroblast collagenase with Ki of 0.4 nM using the synthetic thiol ester substrate Ac-Pro-Leu-Gly-SCH(i-Bu)CO-Leu-Gly-OEt at pH 6.5. The other isomer, 6B, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b23c6f46207e1fa5367652433a08d07
https://pubmed.ncbi.nlm.nih.gov/1322694
https://pubmed.ncbi.nlm.nih.gov/1322694