Zobrazeno 1 - 10
of 553
pro vyhledávání: '"DAI FUKUMURA"'
Autor:
Igor L. Gomes-Santos, Ashwin S. Kumar, Franziska Hausmann, Max N. Meyer, Sarah Z. Shiferaw, Zohreh Amoozgar, Rakesh K. Jain, Dai Fukumura
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionExercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity.MethodsWe subjected mice to low intensity (Li), moderate intensity (Mi) or high in
Externí odkaz:
https://doaj.org/article/3286f5901d15482c9df4530aa3a8ab72
Autor:
Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d26b0562d76f46329dc0083b74f9338e
Autor:
Dai Fukumura, Rakesh K Jain, Peigen Huang, Lance L Munn, Patrik Andersson, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette, Neal I Lindeman, Shanmugarajan Krishnan, Sonu Subudhi, Ashwin Srinivasan Kumar, Jessica Posada, Pinji Lei
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/3a4c2f3027794cf79400ff96ec785d88
Autor:
Anass Agrud, Sivan Subburaju, Pranay Goel, Jun Ren, Ashwin Srinivasan Kumar, Barbara J. Caldarone, Wangde Dai, Jesus Chavez, Dai Fukumura, Rakesh K. Jain, Robert A. Kloner, Anju Vasudevan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Our recent studies uncovered a novel GABA signaling pathway in embryonic forebrain endothelial cells that works independently from neuronal GABA signaling and revealed that disruptions in endothelial GABAA receptor-GABA signaling from early
Externí odkaz:
https://doaj.org/article/a0dbbdf66bb540ea9f25495ef048a18d
Autor:
Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types of hematological malignancies, but have shown limited efficacy in patients with glioblastoma (GBM) or other solid tumors. This may be largely due to the immun
Externí odkaz:
https://doaj.org/article/596a942a981e432ca363975cf37ae1e0
Autor:
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W. Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M. Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B. Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K. Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K. Jain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Glioblastomas (GBM) are frequently resistant to immune checkpoint blockade therapy. Here the authors show that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to P
Externí odkaz:
https://doaj.org/article/1ab21691b67f4af6a88731fc02b3c2eb
Autor:
Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda, Peigen Huang
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-12 (2021)
Abstract Background Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/neu + BC to prevent met
Externí odkaz:
https://doaj.org/article/72ed3803e97d40d080480ecd872ff483
Autor:
Gomes-Santos, Igor L., Kumar, Ashwin S., Hausmann, Franziska, Meyer, Max N., Shiferaw, Sarah Z., Amoozgar, Zohreh, Jain, Rakesh K., Dai Fukumura
Publikováno v:
Frontiers in Immunology; 2024, p1-8, 8p
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 29:1605-1619
Purpose: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a172e9457377d283c4f90bae25db37f3
https://doi.org/10.1158/1078-0432.ccr-22-1630
https://doi.org/10.1158/1078-0432.ccr-22-1630
Autor:
John D. Martin, Ryan M. Lanning, Vikash P. Chauhan, Margaret R. Martin, Ahmed S. Mousa, Walid S. Kamoun, Hee-Sun Han, Hang Lee, Triantafyllos Stylianopoulos, Moungi G. Bawendi, Dan G. Duda, Edward B. Brown, Timothy P. Padera, Dai Fukumura, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 28:3076-3090
Purpose: The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4a5363475591f35309b16beae72815
https://doi.org/10.1158/1078-0432.ccr-22-0486
https://doi.org/10.1158/1078-0432.ccr-22-0486