Analysis of tricarboxylic acid cycle intermediates in dried blood spots by ultraperformance liquid chromatography-tandem mass spectrometry

Autor: Lamia Alhammadi, Maitha Aal Abdulla, Naila Ahli, Nahid Al Dhahouri, Anas Al Aidaros, Fatma Al-Jasmi, Osama Y. Al-Dirbashi

Publikováno v: Journal of Biochemical and Clinical Genetics, Vol 2, Iss 2, Pp 93-98 (2019)

Background: We developed a novel method for measuring the concentrations of tricarboxylic acid (TCA) cycle intermediates in dried blood spots (DBS) using liquid chromatography-tandem mass spectrometry (LC-MS/ MS). Analytes were derivatized before ana

Externí odkaz: https://doaj.org/article/ac2a8eda7de74aa59a4d73c8a5d4effd

Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders

Autor: Osama Y. Al-Dirbashi, Tomofumi Santa, Mohamed S. Rashed, Zuhair Al-Hassnan, Nobuyuki Shimozawa, Aziza Chedrawi, Minnie Jacob, Manhal Al-Mokhadab

Publikováno v: Journal of Lipid Research, Vol 49, Iss 8, Pp 1855-1862 (2008)

Quantification of pristanic acid, phytanic acid, and very long chain fatty acids (i.e., hexacosanoic, tetracosanoic, and docosanoic acids) in plasma is the primary method for investigateing a multitude of peroxisomal disorders (PDs). Typically based

Externí odkaz: https://doaj.org/article/3398154d3dad4069912bc5e45be67fa7

Analysis of 2-methylcitric acid, methylmalonic acid, and total homocysteine in dried blood spots by LC-MS/MS for application in the newborn screening laboratory: A dual derivatization approach.

Autor: Dubland JA; Department of Pathology and Laboratory Medicine, British Columbia Children's Hospital, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Rakić B; Department of Pathology and Laboratory Medicine, British Columbia Children's Hospital, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Vallance H; Department of Pathology and Laboratory Medicine, British Columbia Children's Hospital, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Sinclair G; Department of Pathology and Laboratory Medicine, British Columbia Children's Hospital, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Journal of mass spectrometry and advances in the clinical lab [J Mass Spectrom Adv Clin Lab] 2021 Mar 17; Vol. 20, pp. 1-10. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).