Zobrazeno 1 - 10
of 55
pro vyhledávání: '"D.W. Fairbairn"'
Publikováno v:
Scanning. 18:407-416
Apoptosis is an important form of physiologic cell death displayed by an enormous variety of tissues under divergent conditions. The recent attention toward apoptosis in virtually all aspects of modern biology indicates that rapid and accurate differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66153c4795cbdc6a6530da76bd1a79d6
https://doi.org/10.1002/sca.1996.4950180603
https://doi.org/10.1002/sca.1996.4950180603
Publikováno v:
APOPTOSIS. 3:369-375
Brief mild hyperthermia is sufficient to induce apoptosis (programmed cell death) in many cell lines. Here we describe the effects of a number of factors modulating heat shock induced apoptosis outcomes. We report the effects of cell type, heat load,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ecf68378048277d11f22c2a2c2932a
https://doi.org/10.1023/a:1009689407261
https://doi.org/10.1023/a:1009689407261
Autor:
Kim L. O'Neill, D.W. Fairbairn
Publikováno v:
Apoptosis. 1:91-94
As a sensitive technique for measuring DNA damage, the alkaline comet assay (capable of detecting and distinguishing apoptotic and necrotic damage) shows significantly greater ability to detect DNA breaks than a neutral counterpart. Using a heat shoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::782354db700c413ecae0e8eb348b4734
https://doi.org/10.1007/bf00142083
https://doi.org/10.1007/bf00142083
Autor:
D.W. Fairbairn, Kim L. O'Neill
Publikováno v:
Apoptosis. 1:81-90
Apoptotic DNA cleavage generally proceeds in two stages, first producing large 50–300kb fragments, and later oligonucleosomal pieces which create the characteristic DNA ladder. We show that zinc treatment of hyperthermia-induced apoptotic cultures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65a20a7bcf5b6f7ddfe261de27ce13fc
https://doi.org/10.1007/bf00142082
https://doi.org/10.1007/bf00142082
Publikováno v:
The Breast. 4:79-83
The ability to precisely describe tumour aggressiveness in human breast cancer is inadequate. Current prognostic indicators, although useful, cannot accurately predict tumour behavior. As a result, multivariate analyses are required to obtain any sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::992e7b089a1388c084a123a57ef937e2
https://doi.org/10.1016/0960-9776(95)90000-4
https://doi.org/10.1016/0960-9776(95)90000-4
Autor:
Joshua James Fairbairn, Kirk Joseph Ward, Kim L. O'Neill, D.W. Fairbairn, Brian Willard Loveridge, Mohammad Waleed Khan
Publikováno v:
Cancer Letters. 89:183-188
The biological significance of apoptosis is becoming increasingly clear. Its relevance in tumor response to treatment as well as recent evidence for its important function as a regulating mechanism in tumorigenesis has also been demonstrated. One of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b944eb2aa57403bb6af39a23bff3b47d
https://doi.org/10.1016/0304-3835(94)03668-9
https://doi.org/10.1016/0304-3835(94)03668-9
Publikováno v:
FEMS Microbiology Letters. 123:233-239
The etiology of spongiform encephalopathies has been sharply contested for decades. At the heart of the issue is the question of disease origin: Are prion diseases representative of primary neurodegenerative genetic disorders, or are they bona fide i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17710500da9f0eb2680e37eabe7b408
https://doi.org/10.1111/j.1574-6968.1994.tb07230.x
https://doi.org/10.1111/j.1574-6968.1994.tb07230.x
Publikováno v:
Cancer Letters. 81:67-76
Inherent DNA damage in the form of single strand breaks and alkali labile sites is generated by essential intracellular processes, such as DNA replication and repair. Utilizing the in situ DNA unwinding assay and the comet assay (single cell gel), we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1333ae8c82e2b4ea5499f7fa6d0061c1
https://doi.org/10.1016/0304-3835(94)90166-x
https://doi.org/10.1016/0304-3835(94)90166-x
Autor:
Kim L. O'Neill, Richard N. Thwaits, Kevin G. Carnahan, Richard V. Thwaits, G. Reed Holyoak, D.W. Fairbairn
Publikováno v:
FEMS Microbiology Letters. 115:341-346
The pathogenesis and molecular basis of nerve cell death which accompanies scrapie infections in sheep are not well understood. Degeneration of neurons in culture caused by prion protein fragments has recently been reported to be consistent with mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f04d2cf552c4bde563e0c89f4d7bbf
https://doi.org/10.1111/j.1574-6968.1994.tb06661.x
https://doi.org/10.1111/j.1574-6968.1994.tb06661.x
Publikováno v:
Scanning. 15:136-139
Confocal laser scanning microscopy (CLSM) offers improved depth discrimination and spatial resolution to the analysis of biologic samples. We demonstrate in this paper that such technology is valuable in examining DNA single-strand breaks in human ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fcaaa497f171e5c027781896958f93
https://doi.org/10.1002/sca.4950150305
https://doi.org/10.1002/sca.4950150305