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Autor:
M.A. Kadhim, Melvyn Folkard, Kevin M. Prise, A.M. Malcolmson, Barry D. Michael, D.T. Goodhead, Samantha J. Marsden
Publikováno v:
Radiation Research. 155:122-126
Recent evidence suggests that genomic instability, which is an important step in carcinogenesis, may be important in the effectiveness of radiation as a carcinogen, particularly for high-LET radiations. Understanding the biological effects underpinni
Publikováno v:
Radiation Protection Dosimetry. 52:217-223
Autor:
D.T. Goodhead, M. Belli, A.J. Mill, D.A. Bance, L.A. Allens, S.C. Hall, F. Ianzani, G. Simone, D.L. Stevens, A. Stretch, M.A. Tabocchini, R.E. Wilkinson
Publikováno v:
International Journal of Radiation Biology. 61:611-624
A direct comparison was carried out of the biological effectiveness of protons and alpha-particles of the same linear energy transfer (LET) under identical conditions with a variety of in vitro biological systems. Monolayers of mammalian cells were i
Publikováno v:
International Journal of Radiation Biology. 60:739-756
Calculations of energy deposition in cylindrical target volumes of diameter and height 1-100 nm, including those similar to the dimensions of biological molecules and structures such as DNA, nucleosomes and chromatin fibre, have been made. The calcul
Autor:
D.T. Goodhead, H. Nikjoo
Publikováno v:
Radiation Protection Dosimetry. 31:343-350
Ultrasoft X rays have provided a valuable tool to probe subcellular mechanisms of radiation action. Sufficient data have become available to allow meaningful comparisons between laboratories and between biological assays. A brief summary is given of
Publikováno v:
Advances in space research : the official journal of the Committee on Space Research (COSPAR). 14(10)
Estimation of exposure due to environmental and other sources of radiations of high-LET and low-LET is of interest in radiobiology and radiation protection for risk assessment. To account for the differences in effectiveness of different types of rad