Zobrazeno 1 - 10
of 273
pro vyhledávání: '"D.S.R. Sarma"'
Autor:
Maria Antonietta Seddaiu, M M Simile, M.R. De Miglio, Lucia Daino, Rosa Maria Pascale, D.S.R. Sarma, Srinivasan Rajalakshmi, A. Nufris, Francesco Feo, P.M. Rao
Publikováno v:
Scopus-Elsevier
Chemoprevention of liver carcinogenesis by S-adenosyl-L-methionine (SAM) was studied in F344 male rats. The rats were given 1,2-dimethylhydrazine (1,2-DMH) 2 HCl (100 mg/kg, i.p.) 18 h after two-thirds hepatectomy. One week later they were fed a semi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd87a0de2264d3ad84111f63cd22e23
https://doi.org/10.1093/carcin/16.2.427
https://doi.org/10.1093/carcin/16.2.427
Publikováno v:
Cancer Letters. 81:229-235
One of the hallmarks of initiated hepatocytes is their resistance to several hepatotoxins. This property forms the basis for their selective growth under conditions which are inhibitory to the non-initiated hepatocytes. Selective growth of initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fb0491e26fe28e353f0ef854f6931c
https://doi.org/10.1016/0304-3835(94)90207-0
https://doi.org/10.1016/0304-3835(94)90207-0
Autor:
K. L. Backway, Ezio Laconi, Sharmila Manjeshwar, D.S.R. Sarma, Srinivasan Rajalakshmi, P.M. Rao
Publikováno v:
Carcinogenesis. 15:403-406
It has been hypothesized that orotic acid (OA) promotes rat liver carcinogenesis by a differential mitoinhibitory mode. Consistent with this hypothesis, hepatic nodules are relatively resistant to OA-induced mitoinhibition. OA-induced mitoinhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c4d552991907f45b4187d64f4b870
https://doi.org/10.1093/carcin/15.2.403
https://doi.org/10.1093/carcin/15.2.403
Publikováno v:
Carcinogenesis. 15:1963-1968
One of the proposed mechanisms by which phenobarbital (PB) promotes hepatocarcinogenesis in the rat is by differential mitoinhibition. However, our earlier studies indicated that PB inhibited DNA synthesis in vitro in hepatocytes isolated from both s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740d9d1ceca24ca1b4604ada694aea1b
https://doi.org/10.1093/carcin/15.9.1963
https://doi.org/10.1093/carcin/15.9.1963
Publikováno v:
Chemico-Biological Interactions. 89:35-47
Experiments were conducted to determine whether the excessive orotic aciduria, induced in sparse-fur male mice (spf/Y) deficient in ornithine transcarbamylase (OTC), may be regulated by some inhibitors, such as acivicin (0.014 mmol/100 g body weight,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2a7bc2f724828430cf5875a4ee90da
https://doi.org/10.1016/0009-2797(93)03195-z
https://doi.org/10.1016/0009-2797(93)03195-z
Publikováno v:
Carcinogenesis. 14:1901-1905
The present study was designed to determine the long-term effects of orotic acid (OA), a multi-organ tumor promoter, in rats not exposed to any carcinogen. Male Fischer 344 rats (130-150 g) were divided into two groups and given either a semisyntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de29252044da4f1451693d2fc356fe7
https://doi.org/10.1093/carcin/14.9.1901
https://doi.org/10.1093/carcin/14.9.1901
Publikováno v:
Carcinogenesis. 14:2527-2530
Previous work from this laboratory has revealed that a minimum of 10-20 weeks of continuous exposure to 1% dietary orotic acid (OA) is necessary for this regimen to exert a significant promoting effect on the carcinogenic process in rat liver. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d4604e39ff4fd632642489a87339f0
https://doi.org/10.1093/carcin/14.12.2527
https://doi.org/10.1093/carcin/14.12.2527
Publikováno v:
Experimental Biology and Medicine. 202:25-29
This study was designed to determine whether hepatocytes from hepatic nodules are resistant to the mitoinhibitory effects of orotic acid. Hepatic nodules were initiated in Fischer 344 male rats with 1,2-dimethylhydrazine.2HCl (100 mg/kg ip) given 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b2f254262b828701c61214a5da2975
https://doi.org/10.3181/00379727-202-43511d
https://doi.org/10.3181/00379727-202-43511d
Publikováno v:
Carcinogenesis. 14:1701-1704
The present study was designed to determine whether a delay in the start of the promoting regimen after the administration of a carcinogen would influence the promoting efficacy of orotic acid on the development of hepatocellular carcinoma in rats. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e5cc3077801ec9c3ede8839a2b8522
https://doi.org/10.1093/carcin/14.8.1701
https://doi.org/10.1093/carcin/14.8.1701
Publikováno v:
Carcinogenesis. 13:2287-2291
One of the many hypotheses put forward to explain the mechanism by which phenobarbital (PB) promotes hepatocarcinogenesis is by differential mitoinhibition of surrounding hepatocytes while allowing the initiated hepatocytes to respond to growth stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9444dec04ecb5eedae61aa5bebbb90
https://doi.org/10.1093/carcin/13.12.2287
https://doi.org/10.1093/carcin/13.12.2287