Výsledky vyhledávání - "D.R. McCalla"

The mutational specificity of 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF2) in the lacI gene of Escherichia coli

Autor: Iain B. Lambert, D. W. Bryant, Barry W. Glickman, D.R. McCalla, J.E. Gordon, Tracy A. Chin

Publikováno v: Carcinogenesis. 12:29-34

We have determined the mutational specificity of the 5-nitrofuran derivative furylfuramide (AF2) in the lacI gene of Escherichia coli. Treatment of a delta uvrB, pKM101 strain with 1 M AF2 yielded a mutation frequency approximately 300 times greater

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f872df6a44fe964ed763ce7d9c088a
https://doi.org/10.1093/carcin/12.1.29

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Formation and persistence of DNA adducts in rats following intraperitoneal administration of 1,8-dinitropyrene

Autor: D.W. Bryant, I.B. Lambert, L.M. Davison, D.R. McCalla, C. A. Norman

Publikováno v: Carcinogenesis. 11:1037-1040

DNA adduct formation was examined in rat tissues following a single i.p. injection with 1,8-dinitropyrene (1,8-DNP). A single common adduct was observed in mammary, mesentery, bladder, lung, kidney and liver tissue using the 32P-postlabelling techniq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da124f9ae19dccf7f5144649b1480ca6
https://doi.org/10.1093/carcin/11.6.1037

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The action of 1-nitroso-8-nitropyrene in Escherichia coli: DNA adduct formation and mutational consequences in the absence of nucleotide excision-repair

Autor: D.R. McCalla, D. W. Bryant, Barry W. Glickman, Iain B. Lambert, Alasdair J.E. Gordon

Publikováno v: Carcinogenesis. 12(5)

To study the mechanisms of mutagenesis by the carcinogen 1,8-dinitropyrene we have determined the DNA adducts formed and mutations induced by its partially activated metabolite 1-nitroso-8-nitropyrene (1,8-NONP) in an Escherichia coli strain deficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a51092b0c65def170a25ca30c64756
https://pubmed.ncbi.nlm.nih.gov/2029753

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Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum

Autor: A. J. E. Gordon, Barry W. Glickman, D.R. McCalla, Iain B. Lambert, T. A. Chin, D. W. Bryant

Publikováno v: Nitroarenes ISBN: 9781461366942

Nitrated polyaromatic hydrocarbons (NO2PAH) and nitroheterocyclic compounds are of potential human health importance. NO2PAH are emitted into the environment as byproducts of combustion processes (1), while nitroheterocyclic compounds such as 5-nitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38b77f48b9c2996f7afc0bc9b02a688e
https://doi.org/10.1007/978-1-4615-3800-4_15

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Metabolic activation of 3-nitroperylene in the Salmonella/S9 assay

Autor: Brian E. McCarry, D.W. Bryant, D.R. McCalla, J.G. Anderson, A.M. Bromke

Publikováno v: Mutagenesis. 2:279-285

The mutagenicity of 3-nitroperylene (nitroPer), a nitrated polycyclic aromatic hydrocarbon (PAH) has been extensively studied using the Ames Salmonella test. In accord with previous work, nitroPer proved to be a potent frameshift mutagen which requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a829829944e0130f8c20ce5155685719
https://doi.org/10.1093/mutage/2.4.279

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Nitrofuran-Reducing Enzymes ofEuglena*

Autor: D.R. McCalla, Donna Voutsinos

Publikováno v: The Journal of Protozoology. 22:130-134

SYNOPSIS. Euglena gracilis strain Z, green, dark-grown, and “bleached”with N-methyl-N-nitro-N-nitrosoguanidine, was found to contain 2 soluble enzymes which reduce nitrofurans. A small amount of activity was demonstrated also in a particulate fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41ed5655cc413b1e0279cff67b754be
https://doi.org/10.1111/j.1550-7408.1975.tb00958.x

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Identification of polycyclic aromatic compounds in mutagenic emissions from steel casting

Autor: D.R. McCalla, M. S. Lant, Michael A. Quilliam, C. P. Sheldrake, A. A. Kerr, J. N. Lockington, C. Kaiser-Farrell, E. S. Gibson

Publikováno v: Biological Mass Spectrometry. 12:143-150

Workers in ferrous foundries show increased risk of lung cancer. In the steel casting process hot metal is poured into sand moulds solidified with organic binders, producing a plume of smoke containing a variety of organic compounds and showing stron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dcf93577fe4d7ec21019fb33bc195e
https://doi.org/10.1002/bms.1200120402

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Dinitropyrene-resistant Salmonella typhimurium are deficient in an acetyl-CoA acetyltransferase

Autor: Joan C. Orr, D. W. Bryant, D.R. McCalla, Michael A. Quilliam

Publikováno v: Chemico-Biological Interactions. 54:281-288

Summary Salmonella typhimurium strain TA98NR which is sensitive to 1,8-dinitropyrene mutagenesis possesses acetyl-CoA dependent acetyltransferase activity, while a strain selected for resistance to 1,8-dinitropyrene (TA98/1, 8-DNP6) is deficient in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71540cb56d1785a9980e663914454663
https://doi.org/10.1016/s0009-2797(85)80169-1

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Cytotoxicity and DNA damage to mammalian cells by nitrofurans

Autor: P.L. Olive, D.R. McCalla

Publikováno v: Chemico-Biological Interactions. 16:223-233

Nitrofurazone, nitrofurantoin, furazolidone, furaltadone and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) were toxic to cultured mouse L cells. The extent of toxicity and the rate of reduction of nitrofurazone increased markedly as the oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99eefd432c3d0b4901bb6a7b227839c3
https://doi.org/10.1016/0009-2797(77)90131-4

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