Zobrazeno 1 - 10 of 57 pro vyhledávání: '"D.N. Standring"'
1
Synthesis, Physicochemical and Pharmacokinetic Studies of Potential Prodrugs of β-L-2′-Deoxycytidine, a Selective and Specific Anti-HBV Agent
Autor: Jean-Pierre Sommadossi, Anna Giulia Loi, Samira Benzaria, John Mao, Paolo La Colla, Claire Pierra, Gilles Gosselin, David Dukhan, Edward G. Bridges, D.N. Standring
Publikováno v: Antiviral Chemistry and Chemotherapy. 15:269-279
β-L-2′-Deoxycytidine (β-L-dC) is a potent, selective and specific anti-hepatitis B virus (HBV) agent. To improve its oral bioavailability, several derivatives involving sugar or base acylation, as well as N4-derivatization with an N,N-(dimethyl-a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187ef716d263fc407623f179e570ff83
https://doi.org/10.1177/095632020401500506
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2
Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite
Autor: Erika Cretton-Scott, Ross Fellows, Francis T. Danehy, Nina L. Golitsina, D.N. Standring
Publikováno v: Antiviral research. 85(3)
Nucleoside analogs are effective inhibitors of the hepatitis C virus (HCV) in the clinical setting. One such molecule, 2'-C-methyl-cytidine (2'-MeC), entered clinical development as NM283, a valine ester prodrug form of 2'-MeC possessing improved ora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17552b3d26fa1cb193da616e773a8aa8
https://pubmed.ncbi.nlm.nih.gov/19883694
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3
Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine
Autor: Samira Benzaria, Jean-Pierre Sommadossi, Erika Cretton-Scott, Agnès Amador, Claire Pierra, Steven Mathieu, John Mao, Gilles Gosselin, Marc D'Amours, D.N. Standring, Richard Storer, A. Moussa, Edward G Bridges
Publikováno v: Journal of medicinal chemistry. 49(22)
In our search for new therapeutic agents against chronic hepatitis C, a ribonucleoside analogue, 2'-C-methylcytidine, was discovered to be a potent and selective inhibitor in cell culture of a number of RNA viruses, including the pestivirus bovine vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8de42d3fb4a534a48c110a4bc6289c
https://pubmed.ncbi.nlm.nih.gov/17064080
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4
Synthesis and studies of 3'-C-trifluoromethyl nucleoside analogues bearing adenine or cytosine as the base
Autor: Martin L. Bryant, Christophe Mathé, Paolo La Colla, D.N. Standring, Jean Pierre Sommadossi, Anna Giulia Loi, Gilles Gosselin, Frédéric Jeannot
Publikováno v: Bioorganicmedicinal chemistry. 10(10)
3'-Deoxy-3'-C-CF3, 2',3'-dideoxy-3'-C-CF3 and 2',3'-unsaturated-3'-C-CF3 nucleoside derivatives of adenosine and cytidine have been synthesized. All these derivatives were prepared by glycosylation of adenine and uracil with a suitable peracylated 3-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b07ab72e07cf7f4e34a5d913e8bb519
https://pubmed.ncbi.nlm.nih.gov/12150860
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