Zobrazeno 1 - 8
of 8
pro vyhledávání: '"D.Malcolm Duckworth"'
Autor:
Paul R. Murdock, Graham D Smith, Isro S Gloger, John Terrett, Kathryn Ellington, D.Malcolm Duckworth, Andrew D. Medhurst, Amanda J. L. Barton, Mark H Harries, Christopher D. Benham, Martin J. Gunthorpe, Andrew D. Randall, Helen J. Meadows, Simon Topp, David C. Harrison, Rab K. Prinjha, William Cairns, Catherine E. Clarke, Gareth J. Sanger, Owen Jenkins, John B. Davis, Philip David Hayes
Publikováno v:
Pain. 88:205-215
Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we describe the cloning of a human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a232f7dc9ef6d689e3c5c246cf140a
https://doi.org/10.1016/s0304-3959(00)00353-5
https://doi.org/10.1016/s0304-3959(00)00353-5
Autor:
Vicky Holland, Frank King, Saunders Dv, Graham J. Riley, Thomas P. Blackburn, Derek N. Middlemiss, D.Malcolm Duckworth, Graham Elgin Jones, Jerome Jones, Steven Mark Bromidge, Sean Lightowler, Guy A. Kennett, Martyn D. Wood, Susannah Davies, Steven Dabbs, Ian Thomson Forbes, Brenda K. Trail
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1863-1866
Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d8da8ee47c7d42c8f4723c004ff055
https://doi.org/10.1016/s0960-894x(00)00364-4
https://doi.org/10.1016/s0960-894x(00)00364-4
Autor:
Ian Thomson Forbes, Peter Ham, Thomas P. Blackburn, Saunders Dv, Guy A. Kennett, Angela Gadre, D.Malcolm Duckworth, Vicky Holland, Martyn D. Wood, Deepa Vyas, Steven Dabbs, Graham J. Riley, David T. Davies, Frank King, Susannah Davies, Graham Elgin Jones, Steven Mark Bromidge, Kevin M. Thewlis
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:2767-2773
A model series of 5-HT2C antagonists have been prepared by rapid parallel synthesis. These N-substituted phenyl-N'-pyridin-3-yl ureas were found to have a range of 5-HT2C receptor affinities and selectivities over the closely related 5-HT2A receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e616c20825d452ab463c6f2fee997d
https://doi.org/10.1016/s0968-0896(99)00228-x
https://doi.org/10.1016/s0968-0896(99)00228-x
Autor:
Christopher B. Naylor, Vicky Holland, Susannah Starr, Kevin M. Thewlis, Martyn D. Wood, D.Malcolm Duckworth, Steven Mark Bromidge, Frank King, Thomas P. Blackburn, Steven Dabbs, Peter Ham, Saunders Dv, Graham Elgin Jones, Ian Thomson Forbes, David T. Davies, Frank E. Blaney, Wyman Paul Adrian, and Graham J. Riley, Guy A. Kennett, Fiona Bailey
Publikováno v:
Journal of Medicinal Chemistry. 41:1598-1612
The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB-206553) and illustrate the use of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2bc69439419d750f0f653013b882dd
https://doi.org/10.1021/jm970741j
https://doi.org/10.1021/jm970741j
Autor:
Ian Thomson Forbes, Guy A. Kennett, D.Malcolm Duckworth, Susannah Davies, Derek N. Middlemiss, Jerome Jones, Steven Mark Bromidge, Thomas P. Blackburn, Sean Lightowler, Frank King, Martyn D. Wood, Brenda K. Trail, Vicky Holland, Graham J. Riley, Graham Elgin Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(16)
Bisarylmethoxyethers have been identified with nanomolar 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 1, 2, 8, 12, 14 and 18 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1112043909498eaac4a0b35ff7ca51cb
https://pubmed.ncbi.nlm.nih.gov/10969987
https://pubmed.ncbi.nlm.nih.gov/10969987
Publikováno v:
Trends in pharmacological sciences. 19(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f418053c18cebdd11b51188ab51e8c6f
https://pubmed.ncbi.nlm.nih.gov/9803828
https://pubmed.ncbi.nlm.nih.gov/9803828
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Akademický článek
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