Zobrazeno 1 - 10
of 21
pro vyhledávání: '"D.L. Birdsall"'
Publikováno v:
Protein engineering. 11(3)
X-Ray crystal structures of Lactobacillus casei thymidylate synthase (TS) mutant complexes of E60D with dUMP, and E60Q with dUMP or FdUMP, as well as ternary complexes with folate analog inhibitor CB3717, are described. The structures we report addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a405ac241da279b351742e8d27e19ddb
https://pubmed.ncbi.nlm.nih.gov/9613841
https://pubmed.ncbi.nlm.nih.gov/9613841
Autor:
Javier Apfeld, Robert M. Stroud, Daniel V. Santi, Janet Finer-Moore, Lu Liu, Rachel B. Brem, D.L. Birdsall
Publikováno v:
Journal of molecular biology. 276(1)
We have determined structures of binary and ternary complexes of five Asn229 variants of thymidylate synthase (TS) and related their structures to the kinetic constants measured previously. Asn229 forms two hydrogen bonds to the pyrimidine ring of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a3d9878889dec6b12a057f750856fe
https://pubmed.ncbi.nlm.nih.gov/9514716
https://pubmed.ncbi.nlm.nih.gov/9514716
Autor:
Janet Finer-Moore, Ted Mau, Christian E. Schafmeister, Lu Liu, Robert M. Stroud, Daniel V. Santi, D.L. Birdsall
Publikováno v:
Biochemistry. 35(16)
Thymidylate synthase (TS) methylates only dUMP, not dCMP. The crystal structure of TS‚dCMP shows dCMP 4-NH2 excluded from the space between Asn-229 and His-199 by the hydrogen bonding and steric properties of Asn-229. Consequently, 6-C of dCMP is o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7802faa798016e70249261b5757edb2d
https://pubmed.ncbi.nlm.nih.gov/8611496
https://pubmed.ncbi.nlm.nih.gov/8611496
Publikováno v:
Journal of molecular biology. 255(3)
Three steps along the pathway of binding, orientation of substrates and release of products are revealed by X-ray crystallographic structures of ternary complexes of the wild-type Lactobacillus casei thymidylate synthase enzyme. Each complex was form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0d875d7c0845ab5eec5fdcc474ec3e
https://pubmed.ncbi.nlm.nih.gov/8568895
https://pubmed.ncbi.nlm.nih.gov/8568895
Autor:
D.L. Birdsall
Publikováno v:
The Aeronautical Journal. 111:603-603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c2968d361087d9df5090e6ff5812ce5
https://doi.org/10.1017/s0001924000087200
https://doi.org/10.1017/s0001924000087200
Autor:
D.L. Birdsall
Publikováno v:
The Aeronautical Journal. 104:297-297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59973da16e2058731d3528d44b4582a2
https://doi.org/10.1017/s0001924000091636
https://doi.org/10.1017/s0001924000091636
Autor:
D.L. Birdsall
Publikováno v:
The Aeronautical Journal. 103:358-358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc89ce18275d0afde1d6932e364b73b6
https://doi.org/10.1017/s0001924000064745
https://doi.org/10.1017/s0001924000064745
Autor:
D.L. Birdsall
Publikováno v:
The Aeronautical Journal. 102:299-299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa68108ca306a129607b84963f389de7
https://doi.org/10.1017/s0001924000065362
https://doi.org/10.1017/s0001924000065362
Autor:
D.L. Birdsall
Publikováno v:
The Aeronautical Journal. 102:178-178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba2af4ac4298feccd39aa9afd5044b2
https://doi.org/10.1017/s0001924000065465
https://doi.org/10.1017/s0001924000065465
Autor:
D.L. Birdsall
Publikováno v:
The Aeronautical Journal. 101:34-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59fc828912dbf593970d2e79397548a7
https://doi.org/10.1017/s0001924000066859
https://doi.org/10.1017/s0001924000066859