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Akademický článek
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Publikováno v:
American Journal of Hematology; Feb2004, Vol. 75 Issue 2, p96-100, 5p
Autor:
B.R. Franza, D.L. Aronson
Publikováno v:
Thrombosis Research. 8:329-336
The ability of a procoagulant fraction from the venom of the saw-scaled viper ( Echis carinatus sochureki ) to convert prothrombin to thrombin in the absence of Ca2+ or other cofactors was used as the basis of a sensitive test method for prothrombin.
Autor:
Michèle Amar, Doris Menache, Marie-Claude Guillin, Annie Bezeaud, D.L. Aronson, Nicole Schlegel
Publikováno v:
Thrombosis Research. 10:223-233
After administration of vitamin K antagonists, the liver is able to give rise to a prothrombin molecule which is different from normal prothrombin. This abnormal protein has been isolated using plasma derived from patients under either nicoumalone or
Publikováno v:
Thrombosis Research. 13:551-556
Urine samples of 13 normal subjects and 18 patients with constitutional coagulation defects were screened for the presence of prothrombin derivatives using specific rabbit antisera to human prothrombin, prothrombin Fragment 1 and Prethrombin 2. Patie
Publikováno v:
Thrombosis Research. 20:239-253
Human prothrombin fragments F1(αβ) and F2 were isolated as by-products of α-thrombin preparations. Prothrombin concentrates were activated to > 90% completion with thromboplastin (30–60 min, 23° C). The generated thrombin was quantitatively rem
Publikováno v:
Thrombosis and Haemostasis. 45:034-037
SummaryUrokinases of different molecular weights are now commercially available. An international collaborative study (eight laboratories) has been conducted to investigate the effect of type and concentration of plasminogen on the assay of two diffe
Autor:
Richard G. Hiskey, Jean L Gerth, Don A. Gabriel, Mary E. Scott, D.L. Aronson, Karl A. Koehler, Daniel J Schaefer
Publikováno v:
Thrombosis and Haemostasis. 41:296-308
SummaryVariation of pH strongly affects the fluorescence intensity of human prothrombin fragment-1 in a manner suggesting contributions from a number of protropic equilibria including groups with apparent pKa values near 3.0. These results suggest a
Autor:
D.L. Aronson, D.P. Beebe
Publikováno v:
Thrombosis Research. 51:11-22
The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was label