Zobrazeno 1 - 10
of 185
pro vyhledávání: '"D.K. Morest"'
Publikováno v:
Journal of Neuroscience Research. 90:831-841
To study the mechanisms of noise-induced hearing loss and the phantom noise, or tinnitus, often associated with it, we used a mouse model of noise damage designed for reproducible and quantitative structural analyses. We selected the posteroventral c
Publikováno v:
Journal of Neuroscience Research. 88:86-94
In the developing nervous system, neurotrophin 3 (NT3) and brain-derived neurotrophic factor (BDNF) have been shown to interact with each other and with different parts of a neuron or glia and over considerable distances in time and space. The audito
Publikováno v:
Journal of Neuroscience Research. 77:817-828
The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the pres
Autor:
D.K. Morest, W.Amin Hossain
Publikováno v:
Journal of Neuroscience Research. 62:40-55
To study the effect of FGF in the early development of the sensory neurons of the auditory system, we established a culture preparation of ganglionic neuroblasts engaged in migration and process outgrowth. The presumed anlage of the cochlear ganglion
Publikováno v:
Journal of Neuroscience Research. 58:805-814
We have investigated the influence of voltage-dependent, potassium conductances on the migration of embryonic neurons, using a culture preparation taken from the acoustico-vestibular anlage long before the onset of electrical excitability and synapti
Publikováno v:
Journal of Neuroscience Research. 58:791-804
The Shaw subfamily of potassium channel genes, including Kv3.1, are highly expressed within the auditory nuclei of the brainstem, where they have been implicated in the characteristic response properties of particular types of neurons. Potassium curr
Publikováno v:
Neuroscience. 87:423-437
To explore the role of cell adhesion molecules in the innervation of the inner ear, antibody perturbation was used on histotypic co-cultures of the ganglionic and epithelial anlagen derived from the otocyst. When unperturbed, these tissues survived a
Publikováno v:
Microscopy Research and Technique. 41:205-216
Adult chinchillas were exposed once to an octave-band noise, centered at 4 kHz, and allowed to survive for 16 days or for 1, 2, 4, and 8 months. Axonal degeneration was mapped in the cochlear nucleus, using the Nauta-Rasmussen silver method, and rela
Autor:
D.K. Morest, E.M. Josephson
Publikováno v:
Journal of Neurocytology. 27:841-864
Summary. One of the most numerous neurons in the cochlear nucleus is the type I stellate cell. Previous attempts to understand the structural basis for its signal coding assumed that integration of synaptic potentials arising from axodendritic synaps
Publikováno v:
Experimental Neurology. 147:437-451
The temporal roles of brain-derived neurotrophic factor (BDNF) and fibroblast growth factor-2 (FGF-2) in the development of sensory neurons have been studied in a cell culture preparation which models normal embryonic inner ear development (normocyti