Zobrazeno 1 - 10
of 32
pro vyhledávání: '"D.J. Vidyadhara"'
Autor:
Xi Cheng, Yu Tang, D.J. Vidyadhara, Ben-Zheng Li, Michael Zimmerman, Alexandr Pak, Sanghamitra Nareddula, Paige Alyssa Edens, Sreeganga S. Chandra, Alexander A. Chubykin
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107842- (2023)
Summary: Auxilin (DNAJC6/PARK19), an endocytic co-chaperone, is essential for maintaining homeostasis in the readily releasable pool (RRP) by aiding clathrin-mediated uncoating of synaptic vesicles. Its loss-of-function mutations, observed in familia
Externí odkaz:
https://doaj.org/article/163362be542e416b83b4db41ee5f7e49
Autor:
D.J. Vidyadhara, Mahalakshmi Somayaji, Nigel Wade, Betül Yücel, Helen Zhao, N. Shashaank, Joseph Ribaudo, Jyoti Gupta, TuKiet T. Lam, Dalibor Sames, Lois E. Greene, David L. Sulzer, Sreeganga S. Chandra
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112231- (2023)
Summary: Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of-function mutations cause early-onset Parkinson’s diseas
Externí odkaz:
https://doaj.org/article/9073461150e84963ac6e7e5e81715990
Publikováno v:
Neurotoxicity Research. 39:1892-1907
Parkinson disease (PD) prevalence varies by ethnicity. In an earlier study, we replicated the reduced vulnerability to PD in an admixed population, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6 J, MPTP-resistant CD-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd237d86092b88f63ea981a4b2317b7c
https://doi.org/10.1007/s12640-021-00439-6
https://doi.org/10.1007/s12640-021-00439-6
Autor:
Eduardo Martin-Lopez, D.J. Vidyadhara, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Kimberly Han, Betül Yücel, Sreeganga S. Chandra, Charles A. Greer
Parkinson’s Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological changes in the olfactory pathway of transgenic (Tg) mice expressing the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c90f484de8ea99374e8fb7053312a2
https://doi.org/10.1101/2022.08.19.504562
https://doi.org/10.1101/2022.08.19.504562
Autor:
Chandra Sekhar Boddupalli, Shiny Nair, Glenn Belinsky, Joseph Gans, Erin Teeple, Tri-Hung Nguyen, Sameet Mehta, Lilu Guo, Martin L Kramer, Jiapeng Ruan, Hongge Wang, Matthew Davison, D.J Vidyadhara, Zhang Bailin, Katherine Klinger, Pramod K. Mistry
BackgroundNeuronopathic Gaucher Disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in Gba, and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features, however the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36693d6f82667faed2cec1974d70d3b1
https://doi.org/10.1101/2022.05.13.491834
https://doi.org/10.1101/2022.05.13.491834
Autor:
Ravi Kumar Murumalla, Taslimarif Saiyed, Janhavi Pandurangi, Achyuth Acharya, Malini S. Pillai, Phalguni Anand Alladi, James P. Clement, Abhik Paul, Sumathi Suresh, Lakshmi Garimella, Shashank Rai, D.J. Vidyadhara, Haorei Yarreiphang, Mridhula Giridharan, Ravi Manjithaya
Publikováno v:
EBioMedicine, Vol 50, Iss, Pp 260-273 (2019)
EBioMedicine
EBioMedicine
BACKGROUND: Plethora of efforts fails to yield a single drug to reverse the pathogenesis of Parkinson's disease (PD) and related α-synucleopathies. METHODS: Using chemical biology, we identified a small molecule inhibitor of c-abl kinase, PD180970 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7ee5b37b511d2c908eab4d91f67245
http://www.sciencedirect.com/science/article/pii/S2352396419307066
http://www.sciencedirect.com/science/article/pii/S2352396419307066
Parkinson disease (PD) prevalence varies by ethnicity. In an earlier study we replicated the reduced vulnerability to PD in an admixed population, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6J, MPTP-resistant CD-1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b450411db0f6e61947661ce5e0f4cc8
https://doi.org/10.1101/2020.12.10.419259
https://doi.org/10.1101/2020.12.10.419259
Autor:
Aurel Popa-Wagner, D.J. Vidyadhara, Ravi Mundugaru, Padmaja Udaykumar, Senthilkumar Sivanesan, Kanive Parashiva Guruprasad, Ramalingam Kirubagaran
Publikováno v:
Journal of Chemical Neuroanatomy. 94:75-85
Ischemic brain injury is one of the leading causes of death and disability, where lack of disease modifying treatment strategies make us rely on symptomatic relief. Treatment principles from traditional systems of medicine may fill this gap and its v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f124b0aec12e6def27763b636aa758
https://doi.org/10.1016/j.jchemneu.2018.09.002
https://doi.org/10.1016/j.jchemneu.2018.09.002
Publikováno v:
J Neurochem
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting 1-1.5% of the total population. While progress has been made in understanding the neurodegenerative mechanisms that lead to cell death in late stages of PD, mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d4570794288b9cc23891010918299a
https://pubmed.ncbi.nlm.nih.gov/31287913
https://pubmed.ncbi.nlm.nih.gov/31287913
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