Zobrazeno 1 - 10
of 100
pro vyhledávání: '"D.J. Pratt"'
Autor:
Yi Chen, Lan-Zhen Wang, J Bentley, AE Gibson, Philip J. Jewsbury, Bernard T. Golding, D.J. Pratt, FT Boyle, H.J. Whitfield, Mesguiche, Martin E.M. Noble, J Menyerol, Jane A. Endicott, Ian R. Hardcastle, Roger John Griffin, David Richard Newell, C.E. Arris, Nicola J. Curtin
Publikováno v:
Journal of Medicinal Chemistry. 47:3710-3722
The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1147603822315847f8cd9ae98536ed81
https://doi.org/10.1021/jm0311442
https://doi.org/10.1021/jm0311442
Autor:
Philip J. Jewsbury, Jane A. Endicott, Veronique Mesguiche, Nicola J. Curtin, J Bentley, Rachel Parsons, David R. Newell, Yuzhu Cheng, Lan Z. Wang, Martin E.M. Noble, Ian R. Hardcastle, Kerry L. Sayle, A. Hilary Calvert, D.J. Pratt, Roger J. Griffin, F. Thomas Boyle, Bernard T. Golding
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3079-3082
A series of O 4 -cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity. Consistent with analogous studies with O 6 -cyclohexylmethylpurines, 2-arylaminopyrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6f62b7e5cd369e405ae7ba2abe0ed2
https://doi.org/10.1016/s0960-894x(03)00651-6
https://doi.org/10.1016/s0960-894x(03)00651-6
Autor:
D.J. Pratt, W.H. Sanner
Publikováno v:
The Foot. 6:99-111
This paper outlines the rationale for the provision of foot orthoses for paediatric patients with biomechanical foot disorders. It examines the gait and normal morphology of children and then presents some of the more common foot deformities. These a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c40b43e7b0c04b256b967935b1f40f8
https://doi.org/10.1016/s0958-2592(96)90000-0
https://doi.org/10.1016/s0958-2592(96)90000-0
Autor:
D.J. Pratt
Publikováno v:
The Foot. 5:101-110
then there are a wide range of devices which are foot orthoses. This range would include footwear with adaptions, ‘simple’ insoles and pads and the rigid foot orthoses produced from casts of the foot. It is the latter of these on which this artic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f357d842c8a5fa1f7ab243d9d198d1e1
https://doi.org/10.1016/0958-2592(95)90000-4
https://doi.org/10.1016/0958-2592(95)90000-4
Autor:
G. Zafiropoulos, D.J. Pratt
Publikováno v:
Injury. 25:331-336
Fractures of the trochanteric region of the femur are common in the elderly and their operative treatment is controversial. Many devices have been used surgically without any particular method being positively indicated. The sliding screw and plate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f7586b4100f65fb159fbd3503ff801
https://doi.org/10.1016/0020-1383(94)90248-8
https://doi.org/10.1016/0020-1383(94)90248-8
Autor:
D.J. Pratt
Publikováno v:
Clinical Biomechanics. 6:67-72
In an attempt to provide quantitative data on the functional performance of six selected knee orthoses a 9-D electrogoniometric study was initiated. Using a TRIAX electrogoniometer the orthoses were compared in a group of ten subjects during normal l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd289d6b38f030c6511880538559e0fb
https://doi.org/10.1016/0268-0033(91)90001-7
https://doi.org/10.1016/0268-0033(91)90001-7
Publikováno v:
Journal of medicinal chemistry. 49(18)
Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1748ee07760194d1678edbad98d5ef0
https://pubmed.ncbi.nlm.nih.gov/16942020
https://pubmed.ncbi.nlm.nih.gov/16942020
Publikováno v:
Biochimica et biophysica acta. 1754(1-2)
The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb7afda61fb25a0ff4f6640fe0dbf49
https://pubmed.ncbi.nlm.nih.gov/16271522
https://pubmed.ncbi.nlm.nih.gov/16271522
Autor:
D.M. Staggs, D.J. Pratt
Publikováno v:
IEEE 1988 International Symposium on Electromagnetic Compatibility.
An overview is given of the activities and directions of the various worldwide committees working on the electrostatic discharge (ESD) phenomena. The current technical issues, position, and documentation status are discussed for each committee. The t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b7a17a0b08bb16d13a19a57109cc365
https://doi.org/10.1109/isemc.1988.14112
https://doi.org/10.1109/isemc.1988.14112
Publikováno v:
The Foot. 4:31-33
This paper reports on a foot orthosis which successfully provides limitation of pronation (primarily) and supination via dorsal foot control. It is felt that this orthosis offers a useful intermediate device between a heel cup and an ankle foot ortho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2eb308c766b0a5f29db4885c57ecb8a
https://doi.org/10.1016/0958-2592(94)90010-8
https://doi.org/10.1016/0958-2592(94)90010-8