Zobrazeno 1 - 10
of 438
pro vyhledávání: '"D.J. Pearson"'
Autor:
Lucas Moreno, Steven G. DuBois, Julia Glade Bender, Audrey Mauguen, Nick Bird, Vickie Buenger, Michela Casanova, François Doz, Elizabeth Fox, Lia Gore, Douglas S. Hawkins, Shai Izraeli, David T.W. Jones, Pamela R. Kearns, Jan J. Molenaar, Karsten Nysom, Stefan Pfister, Gregory Reaman, Malcolm Smith, Brenda Weigel, Gilles Vassal, Christian Michel Zwaan, Xavier Paoletti, Alexia Iasonos, Andrew D.J. Pearson
Publikováno v:
Scientia
PURPOSE There is an increasing need to evaluate innovative drugs for childhood cancer using combination strategies. Strong biological rationale and clinical experience suggest that multiple agents will be more efficacious than monotherapy for most di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cfed0b001a0a7bb4dbc82e8b4ec2a0
https://hdl.handle.net/11351/9922
https://hdl.handle.net/11351/9922
Autor:
Elizabeth Fox, Michael Berntgen, Alfonso Quintás-Cardama, Veronique Minard-Colin, Susan L. Weiner, André Baruchel, Laura Pearce, Karsten Nysom, Andrew D.J. Pearson, Danielle H. Taylor, Christian M. Zwaan, Nirali N. Shah, Yousif Matloub, Ivan D. Horak, Gregory H. Reaman, Gilles Vassal, Koen Norga, Claudia Rossig, Dominik Karres, Lori A. Ehrlich, Martina Schüßler-Lenz, Alberto S. Pappo, Joe McDonough, Martina A. Sersch, Nick Richardson, Donna Ludwinski, Abraham Bassan, Eric Bleickardt, Nicole Scobie, Stephen Gottschalk, Rob Pieters, Sarah K. Tasian, Courtney Johnson, Teresa de Rojas, Malcolm A. Smith, Franca Ligas, Lynley V. Marshall, Shannon L. Maude, Brenda J. Weigel, Nick Bird, Najat Bouchkouj, Behzad K. Masouleh, Sarah Beaussant Cohen, Delphine Heenen, Rosanna Ricafort, G. Lesa, Linda Hanssens, Peter F. Bross, Carrie Brownstein, Crystal L. Mackall, Martin Pule, Douglas S. Hawkins, Jaroslav Sterba, Maksim Mamonkin
Publikováno v:
European Journal of Cancer. 160:112-133
The seventh multi-stakeholder Paediatric Strategy Forum focused on chimeric antigen receptor (CAR) T-cells for children and adolescents with cancer. The development of CAR T-cells for patients with haematological malignancies, especially B-cell precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::109dc83dd17c2fd2077a3e812e4df67f
https://doi.org/10.1016/j.ejca.2021.10.016
https://doi.org/10.1016/j.ejca.2021.10.016
Autor:
James A. Whitlock, Mark W. Russo, Steven Green, Noelia Nebot, Lillian Tseng, Andrew D.J. Pearson, Christine A. Pratilas, Eric Bouffet, Violet Shen, Trent R. Hummel, Kenneth J. Cohen, Anne-Isabelle Bertozzi, Isabelle Aerts, Pooja Hingorani, Darren Hargrave, Alberto Broniscer, Ira J. Dunkel, Birgit Geoerger, Mark W. Kieran
Adverse events, regardless of study drug relationship, by preferred term and maximum grade (>20% overall)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096eb85b1f2bfc9a225c8680377df825
https://doi.org/10.1158/1078-0432.22472558
https://doi.org/10.1158/1078-0432.22472558
Autor:
Chris Jones, Paul Workman, David W. Ellison, Darren Hargrave, Andrew D.J. Pearson, Gilles Vassal, Rui M. Reis, Safa Al-Sarraj, João N. Stávale, Jorge S. Reis-Filho, Swee Y. Sharp, Raisa Vuononvirta, Marta Viana-Pereira, Marie Regairaz, Lara Perryman, Lynley Marshall, Suzanne E. Little, Nathalie Gaspar, Dorine A. Bax
Purpose: The epidermal growth factor receptor (EGFR) is amplified and overexpressed in adult glioblastoma, with response to targeted inhibition dependent on the underlying biology of the disease. EGFR has thus far been considered to play a less impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6f20bbf3a397a92e286ae0d352d4a8
https://doi.org/10.1158/1078-0432.c.6517390
https://doi.org/10.1158/1078-0432.c.6517390
Autor:
Susan N. Chi, Sudha Parasuraman, Jason R. Dobson, Suraj G. Bhansali, Alessandro Matano, Marlyane Motta, Giles W. Robinson, Thomas Cash, Shakeel Modak, Andrew D.J. Pearson, Aurélien Marabelle, Nicholas G. Gottardo, James I. Geller, Matthias Fischer, Steven G. DuBois, Franck Bourdeaut, Birgit Geoerger
Pub fees email yes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d51f0ad014a0e5d759351e185cfaf4
https://doi.org/10.1158/1078-0432.22467020.v1
https://doi.org/10.1158/1078-0432.22467020.v1
Autor:
Darren Hargrave, Murray Yule, Melanie J. Griffin, Alan V. Boddy, John F. Lyons, Ana Rodriguez, Victoria Lock, Shamim Kazmi-Stokes, Philip Ross, Gary Acton, Sarah E.R. Halford, Guy Makin, Quentin Campbell-Hewson, Martin Elliott, Bruce Morland, Andrew D.J. Pearson, Lynley V. Marshall, Lucas Moreno
Supplementary Figure 1. Examples of changes observed in M30/M65 profiles as a function of dosing of AT9283 in two selected patients. Pt. 58/032 from cohort 4 (14.5 mg/m2/day) and Pt. 31/030 from cohort 6 (23 mg/m2/day).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecad42031facf935942fc7b688af840e
https://doi.org/10.1158/1078-0432.22460577.v1
https://doi.org/10.1158/1078-0432.22460577.v1
Autor:
Chris Jones, Paul Workman, David W. Ellison, Darren Hargrave, Andrew D.J. Pearson, Gilles Vassal, Rui M. Reis, Safa Al-Sarraj, João N. Stávale, Jorge S. Reis-Filho, Swee Y. Sharp, Raisa Vuononvirta, Marta Viana-Pereira, Marie Regairaz, Lara Perryman, Lynley Marshall, Suzanne E. Little, Nathalie Gaspar, Dorine A. Bax
Supplementary Data from EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb9fa3e4c6dece4dde15dbc50c03193
https://doi.org/10.1158/1078-0432.22440010
https://doi.org/10.1158/1078-0432.22440010
Autor:
James A. Whitlock, Mark W. Russo, Steven Green, Noelia Nebot, Lillian Tseng, Andrew D.J. Pearson, Christine A. Pratilas, Eric Bouffet, Violet Shen, Trent R. Hummel, Kenneth J. Cohen, Anne-Isabelle Bertozzi, Isabelle Aerts, Pooja Hingorani, Darren Hargrave, Alberto Broniscer, Ira J. Dunkel, Birgit Geoerger, Mark W. Kieran
Purpose:The 2-part, phase I/IIa, open-label study (NCT01677741) sought to determine the safety, tolerability, pharmacokinetics, and preliminary activity of dabrafenib in pediatric patients with advanced BRAF V600–mutated cancers.Patients and Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fd5f95aec3525ee84d5557f83cca23
https://doi.org/10.1158/1078-0432.c.6528263.v1
https://doi.org/10.1158/1078-0432.c.6528263.v1
Autor:
Alan V. Boddy, Andrew D.J. Pearson, Ann K. Daly, Michael Cole, Ghada Malik, Nicola A. Illingworth, Sophie E. Rowbotham, Julie Errington, Gareth J. Veal
PDF file - 72K, Observed and fitted 13-cisRA data from four patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4e2bc41b377f2d8d1a9ee8a3826532
https://doi.org/10.1158/1078-0432.22455344.v1
https://doi.org/10.1158/1078-0432.22455344.v1
Autor:
Alan V. Boddy, Andrew D.J. Pearson, Ann K. Daly, Michael Cole, Ghada Malik, Nicola A. Illingworth, Sophie E. Rowbotham, Julie Errington, Gareth J. Veal
PDF file - 43K, Relationship between 13-cisRA AUC0-6h and 13-cisRA Cmax determined from pharmacokinetic profiles obtained following protocol-based 13-cisRA dosing (n=103)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ed9912ffabfaae1260fd952fa157e2
https://doi.org/10.1158/1078-0432.22455341
https://doi.org/10.1158/1078-0432.22455341