Phase 2 ventricular arrhythmias in acute myocardial infarction: a neglected target for therapeutic antiarrhythmic drug development and for safety pharmacology evaluation

Autor: Hugh Clements-Jewery, D.J. Hearse, Michael J. Curtis

Publikováno v: British Journal of Pharmacology. 145:551-564

Ventricular fibrillation (VF), a cause of sudden cardiac death (SCD) in the setting of acute myocardial infarction (MI), remains a major therapeutic challenge. In humans, VF may occur within minutes or hours after the onset of chest pain, so its prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b77a762f929fe9d5be45f74b4c5e66d4
https://doi.org/10.1038/sj.bjp.0706231

Ischaemia, reperfusion and cardioprotection: successes and failures in the journey from molecule to man

Autor: D.J. Hearse

Publikováno v: European Heart Journal Supplements. 3:C11-C21

In response to the increasing toll of ischaemic heart disease, the last 50 years have seen an enormous amount of research aimed at understanding the biology of ischaemia and developing methods to control it. Much of this research has used animal mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e25c2b3dc39bc64044b684551c3248c
https://doi.org/10.1016/s1520-765x(01)90025-2

Influence of low-flow infusion and magnesium on tissue necrosis during regional ischemia in the canine myocardium

Autor: Y Qiu, Jr Jg Kingma, D.J. Hearse

Publikováno v: Canadian Journal of Physiology and Pharmacology. 70:1004-1010

Passive intracoronary perfusion of therapeutic agents has been used in the clinical setting to attenuate the effects of brief episodes of myocardial ischemia. The objective of this study was to assess the effects of low-flow coronary infusion with or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73443cbfa76663b1c971d8c0b29e352d
https://doi.org/10.1139/y92-138

Contributors

Autor: Jun-ichi Abe, Hugues Abriel, Eric A. Accili, Daniel Acosta, Lee F. Allen, Tara J. Allen, Charles Antzelevitch, Hiroki Aoki, Jeffrey L. Ardell, Makoto Arita, Morton F. Arnsdorf, John A. Auchampach, Shmuel Banai, Jacques Barhanin, M. Baruscotti, Brian M. Bennett, Bradford C. Berk, Donald M. Bers, Marvin Boluyt, Mulugu V. Brahmajothi, Eugene Braunwald, Alexander Burashnikov, Donald L. Campbell, D.J. Chambers, Frédéric Charron, Vijay S. Chauhan, Guoxiang Chu, Michael V. Cohen, Humbert De Smedt, Naranjan S. Dhalla, D. DiFrancesco, James M. Downey, Milou D. Drici, Guy Droogmans, Istvan Edes, Masao Endoh, Denis Escande, Michael S. Forbes, Akikazu Fujita, Tetsushi Furukawa, A. Marquis Gacy, Antony Galione, S. David Gertz, Augustus O. Grant, Christopher D. Hardin, Robert D. Harvey, Armin Haunstetter, D.J. Hearse, Gerd Heusch, Yuji Hirano, Masayasu Hiraoka, Franz Hofmann, Masatsugu Hori, Steven R. Houser, Joseph R. Hume, Seigo Izumo, Arshad Jahangir, Aleksandar Jovanovic, Sofija Jovanovic, Paul F. Kantor, Gary J. Kargacin, Robert S. Kass, Seiko Kawano, Junko Kimura, Masafumi Kitakaze, Kenji Kitamura, Evangelia G. Kranias, Iftikhar J. Kullo, Yoshihisa Kurachi, Adi Kurgan, Lubica Lacinová, Edward G. Lakatta, Amir Lerman, Andrew P. Levy, Jon W. Lomasney, Gary D. Lopaschuk, Benedict R. Lucchesi, Jane A. Madden, Jonathan C. Makielski, Ali J. Marian, Jure Marijic, Donald H. Maurice, William G. Mayhan, Gerhard Meissner, Ludwig Missiaen, Michael J. Morales, A. Moroni, Mariko Nakamura, Mona Nemer, Jeanne M. Nerbonne, Thomas Netticadan, Bernd Nilius, Katsushige Ono, Lionel H. Opie, Jan B. Parys, Richard J. Paul, Amir Pelleg, Carmen M. Perez-Terzic, Valentino Piacentino, Jan J. Piek, Giovanni M. Pitari, M. Pucéat, Stevan Rakovic, Ilaria Rivolta, Robert Roberts, Richard B. Robinson, Rosita J. Rodriguez, Michael R. Rosen, Yoram Rudy, Nancy J. Rusch, Manjot S. Sandhu, Jutta Schaper, Wolfgang Schaper, Win-Kuang Shen, Maria Siebes, Robert D. Simari, R. John Solaro, Jos A.E. Spaan, Nicholas Sperelakis, David C. Spray, Miduturu Srinivas, Susan F. Steinberg, Joseph R. Stimers, Harold C. Strauss, Sylvia O. Suadicani, Masanori Sunagawa, James Surapisitchat, Masayuki Tanemoto, Rana M. Temsah, Derek Terrar, Andre Terzic, Noritsuga Tohse, Ligia Toro, Helmut A. Tritthart, David R. Van Wagoner, Guy Vassort, Monique J. Vink, Gordon M. Wahler, Scott A. Waldman, Michael P. Walsh, Shimin Wang, Stephanie H. Wilson, Rui-Ping Xiao, Jun Yamazaki, Chen Yan, Hisashi Yokoshiki, Ying-Ying Zhou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6f12433d86e0d42684a0a21dfe60d4e
https://doi.org/10.1016/b978-012656975-9/50000-6

Are reperfusion-induced arrhythmias caused by disinhibition of an arrhythmogenic component of ischemia?

Autor: Tomoaki Nakata, D.J. Hearse, Michael J. Curtis

Publikováno v: Journal of molecular and cellular cardiology. 22(8)

Isolated rat hearts were used to examine whether reperfusion-induced arrhythmias may be caused by washout of substances accumulating during ischemia. This was achieved by subjecting hearts to 10 min of regional ischemia and rendering them transiently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731cc233767f5781cd4885086f3657de
https://pubmed.ncbi.nlm.nih.gov/2231748