Zobrazeno 1 - 10
of 19
pro vyhledávání: '"D.J. Ebbrell"'
Autor:
Bruno Campos, Maria Sapounidou, Mark T. D. Cronin, Steve Gutsell, James W. Firman, Mark Bonnell, Geoff Hodges, D.J. Ebbrell, Jayne Roberts
Publikováno v:
Environmental Science & Technology. 55:1897-1907
This study developed a novel classification scheme to assign chemicals to a verifiable mechanism of (eco-)toxicological action to allow for grouping, read-across, and in silico model generation. The new classification scheme unifies and extends exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03054b99dc4cf9eb02e1e3ca9da79791
https://doi.org/10.1021/acs.est.0c06551
https://doi.org/10.1021/acs.est.0c06551
Autor:
D.J. Ebbrell, James W. Firman, Mathieu Vinken, Mark T. D. Cronin, Tamara Vanhaecke, Nicoleta Spinu, Emma Arnesdotter
Adverse outcome pathways (AOPs) and their networks are important tools for the development of mechanistically based non-animal testing approaches, such as in vitro and/or in silico assays, to assess toxicity induced by chemicals. In the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6190381ba1db21b321d4aa1843d0c7e
https://biblio.vub.ac.be/vubir/derivation-characterisation-and-analysis-of-an-adverse-outcome-pathway-network-for-human-hepatotoxicity(6bdf2d80-55f7-4a02-a1aa-d547c3b2f299).html
https://biblio.vub.ac.be/vubir/derivation-characterisation-and-analysis-of-an-adverse-outcome-pathway-network-for-human-hepatotoxicity(6bdf2d80-55f7-4a02-a1aa-d547c3b2f299).html
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071601495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffb3191e43cf4d1be11f494d1442d7e4
https://doi.org/10.1007/978-1-0716-0150-1_15
https://doi.org/10.1007/978-1-0716-0150-1_15
Publikováno v:
Chemical Research in Toxicology. 29:1073-1081
The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a194ddb72fa5bd27dcce031d4fb5cfd0
https://doi.org/10.1021/acs.chemrestox.6b00099
https://doi.org/10.1021/acs.chemrestox.6b00099
Publikováno v:
Chemical research in toxicology. 30(2)
This study outlines the use of a recently developed fragment-based thiol reactivity profiler for Michael acceptors to predict toxicity towards Tetrahymena pyriformis and skin sensitisation potency as determined in the Local Lymph Node Assay (LLNA). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fdd4db7a1cbd7fea9160133ed11bf9
https://pubmed.ncbi.nlm.nih.gov/28045255
https://pubmed.ncbi.nlm.nih.gov/28045255
Autor:
Judith C. Madden, Mark T. D. Cronin, D.J. Ebbrell, Steven D. Webb, Julia Pletz, James W. Firman, Steven J. Enoch
Publikováno v:
Toxicology Letters. 295:S97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb4a6cf8969c11fffc61b0d5d475ce74
https://doi.org/10.1016/j.toxlet.2018.06.598
https://doi.org/10.1016/j.toxlet.2018.06.598
Publikováno v:
Toxicology Letters. 295:S100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::348ade842ed077c442030801c61df51f
https://doi.org/10.1016/j.toxlet.2018.06.606
https://doi.org/10.1016/j.toxlet.2018.06.606
Autor:
Bruno Bienfait, Judith C. Madden, Mark T. D. Cronin, Aleksandra Mostrag-Szlichtyng, Chihae Yang, Steven J. Enoch, James W. Firman, Vessela Vitcheva, D.J. Ebbrell, James F. Rathman
Publikováno v:
Toxicology Letters. 295:S101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de09777a94e87c79c891391bb969978
https://doi.org/10.1016/j.toxlet.2018.06.610
https://doi.org/10.1016/j.toxlet.2018.06.610
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Akademický článek
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