Zobrazeno 1 - 10
of 146
pro vyhledávání: '"D.J. Antoine"'
Autor:
E.A. Lock, D.J. Antoine
The kidney possess most of the common drug-metabolising enzymes, and thus is able to make an important contribution to the body’s metabolism of drugs and other xenobiotics. The catalytic activity of the various enzymes is lower than in the liver, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf673d8ecc2d3018caa7af96d3487be
https://doi.org/10.1016/b978-0-12-801238-3.95644-7
https://doi.org/10.1016/b978-0-12-801238-3.95644-7
BackgroundA biomarker that stratifies patients with complications of gallstone disease from the denominator pool of people with acute biliary-type symptoms is needed. Circulating microRNA-122 (miRNA-122), high-mobility group box1 (HMGB1), full-length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e50b76ec65cce1615ea77ce334cb5f
https://doi.org/10.1101/189589
https://doi.org/10.1101/189589
Autor:
Michael W. Beresford, Patricia Murray, Daniel B Hawcutt, Bettina Wilm, Chris Barton, Rachel V. Floyd, Ian M. Copple, Stephen J McWilliam, D.J. Antoine, Louise Oni, Mark A. Turner, Matthew Peak, B.K. Park, Animesh Sharma
Publikováno v:
Pharmacology and Therapeutics
The majority of medications in children are administered in an unlicensed or off-label manner. Paediatricians are obliged to prescribe using the limited evidence available. The 2007 EU regulation on the use of paediatric drugs means pharmaceutical co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a81065843715269e11846dbb9361cb1
Autor:
Joanna I. Clarke, David M. Wood, D. N. Bateman, Paul I. Dargan, D.J. Antoine, Jamie G. Cooper, J.H. Seymour, James W. Dear, Michael Eddleston, Alasdair Gray, A. D. B. Vliegenthart, David J. Webb, Robert Kimmitt, Natalie Z.M. Homer, Steff C. Lewis
Publikováno v:
Clinical Pharmacology and Therapeutics
Vliegenthart, B, Kimmitt, R A, Seymour, JH, Homer, N, Clarke, J I, Eddleston, M, Gray, A, Wood, D M, Dargan, P I, Cooper, J G, Antoine, D J, Webb, D, Lewis, S, Bateman, D N & Dear, J 2017, ' Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury ', Clinical pharmacology and therapeutics, vol. 101, no. 4, pp. 531-540 . https://doi.org/10.1002/cpt.541
Vliegenthart, B, Kimmitt, R A, Seymour, JH, Homer, N, Clarke, J I, Eddleston, M, Gray, A, Wood, D M, Dargan, P I, Cooper, J G, Antoine, D J, Webb, D, Lewis, S, Bateman, D N & Dear, J 2017, ' Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury ', Clinical pharmacology and therapeutics, vol. 101, no. 4, pp. 531-540 . https://doi.org/10.1002/cpt.541
Acetaminophen (paracetamol-APAP) is the most common cause of drug-induced liver injury in the Western world. Reactive metabolite production by cytochrome P450 enzymes (CYP-metabolites) causes hepatotoxicity. We explored the toxicokinetics of human ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe56a30d649934423db3e04e2c416d65
https://pubmed.ncbi.nlm.nih.gov/27770431
https://pubmed.ncbi.nlm.nih.gov/27770431
Autor:
Neil C. Henderson, D G Craig, Andrea Caporali, Laura E J Peeters, Kenneth J. Simpson, Jonathan M Shaffer, A. D. B. Vliegenthart, Alexandra I. Thompson, Joanna I. Clarke, David J. Webb, Joanna Moore, James W. Dear, Jack Sharkey, Eric Lader, B.K. Park, D. N. Bateman, Paul I. Dargan, Matthew A. Bailey, D.J. Antoine, David M. Wood
Publikováno v:
Scientific Reports
Vliegenthart, A D B, Shaffer, J M, Clarke, J I, Peeters, L E J, Caporali, A, Bateman, D N, Wood, D M, Dargan, P I, Craig, D G, Moore, J K, Thompson, A I, Henderson, N C, Webb, D J, Sharkey, J, Antoine, D J, Park, B K, Bailey, M A, Lader, E, Simpson, K & Dear, J W 2015, ' Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury ', Scientific Reports, vol. 5, pp. 15501 . https://doi.org/10.1038/srep15501
Vliegenthart, A D B, Shaffer, J M, Clarke, J I, Peeters, L E J, Caporali, A, Bateman, D N, Wood, D M, Dargan, P I, Craig, D G, Moore, J K, Thompson, A I, Henderson, N C, Webb, D J, Sharkey, J, Antoine, D J, Park, B K, Bailey, M A, Lader, E, Simpson, K & Dear, J W 2015, ' Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury ', Scientific Reports, vol. 5, pp. 15501 . https://doi.org/10.1038/srep15501
Our objective was to identify microRNA (miRNA) biomarkers of drug-induced liver and kidney injury by profiling the circulating miRNome in patients with acetaminophen overdose. Plasma miRNAs were quantified in age- and sex-matched overdose patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb470e32852d05c62c02f667bbc9359
Autor:
P.J. Starkey Lewis, Jonathan G. Moggs, Philippe Couttet, Brian Kevin Park, James W. Dear, D.J. Antoine, M Merz, Olivier Grenet, Christopher E. Goldring
Publikováno v:
Clinical Pharmacology & Therapeutics. 92:291-293
New biomarkers of drug-induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver-enriched microRNAs are promising serum biomarkers of acetaminophen-induced acute liver injury in mice. The utility of ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0cccc96aaa2d10243be3c5237b9c35
https://doi.org/10.1038/clpt.2012.101
https://doi.org/10.1038/clpt.2012.101
Autor:
James W. Dear, Bastiaan Vliegenthart, Kevin Park, Neeraj Dhaun, D.J. Antoine, K. M. Scullion, Wilna Oosthuyzen, David J. Webb
Publikováno v:
Toxicology Letters. 238:S153-S154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d227cbabc6222351bdd936f423436b96
https://doi.org/10.1016/j.toxlet.2015.08.478
https://doi.org/10.1016/j.toxlet.2015.08.478
Autor:
H. Erlandsson Harris, Marie Fischer, Rosalind E. Jenkins, D.J. Antoine, Peter Lundbäck, Erik Sundberg, Lena Klevenvall, Pernilla Stridh, Ulf Andersson
Publikováno v:
Annals of the Rheumatic Diseases. 74:A27.1-A27
Background and objectives High mobility group box protein 1 (HMGB1) is a prototypic alarmin being released from activated, stressed or dying cells. Extracellular HMGB1 has the ability to induce cell migration as well as cytokine production. Pathogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d2c0bcf5b4c93868d790cc90038802a
https://doi.org/10.1136/annrheumdis-2015-207259.63
https://doi.org/10.1136/annrheumdis-2015-207259.63
Autor:
James W. Dear, Joseph V. Bonventre, Ken Simpson, Venkata S. Sabbisetti, D G Craig, Kevin Park, D.J. Antoine
Publikováno v:
Toxicology Letters. 229:S97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7cd53cce0107f4d100c51d00f006d3
https://doi.org/10.1016/j.toxlet.2014.06.358
https://doi.org/10.1016/j.toxlet.2014.06.358
Autor:
Karin Palmblad, Hanna Schierbeck, D.J. Antoine, Erik Sundberg, Ulf Andersson, Jan-Inge Henter, Helena Erlandsson Harris, AnnaCarin Horne
Publikováno v:
Pediatric Rheumatology Online Journal
Macrophage activation syndrome (MAS) is a life-threatening complication of childhood systemic inflammatory disorders. HMGB1 is a nuclear protein that extracellularly orchestrates key events in inflammation. Recent data revealed that different redox s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadcb2ad31130f334b32f3127144f27d
http://europepmc.org/articles/PMC4184275
http://europepmc.org/articles/PMC4184275