Zobrazeno 1 - 10
of 80
pro vyhledávání: '"D.G. Meuleman"'
Autor:
Jeffry A. J. Wisse, Maurice Petitou, Vanessa Nancy-Portebois, D.G. Meuleman, Martin de Kort, Constant A. A. van Boeckel, Gerard M. T. Vogel, Vincent Motte, Guy Dubreucq
Publikováno v:
Thrombosis and Haemostasis, 102(5), 804-810. Schattauer GmbH
SummaryThe elucidation of the structure of the antithrombin binding sequence in heparin has given a large impulse to the rational design of heparin related drugs. De novo chemical synthesis of the corresponding pentasaccharide as well as simplified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e6e79ccd1d36af2e25f70c56617a07
https://doi.org/10.1160/th09-01-0063
https://doi.org/10.1160/th09-01-0063
Autor:
D.G. Meuleman, G.M.T. Vogel, Rienk Nieuwland, A. Sturk, Anita N. Böing, F.J. Hoek, M. N. Abid Hussein, E. Biro
Publikováno v:
Thrombosis research, 121(6), 865-871. Elsevier Limited
Introduction: Microparticles from activated endothelial cells (EMP) are well known to expose tissue factor (TF) and initiate coagulation in vitro. TF coagulant activity is critically dependent on the presence of aminophospholipids, such as phosphatid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80054e44708b6a8c2859aaa8878bcd
https://doi.org/10.1016/j.thromres.2007.08.005
https://doi.org/10.1016/j.thromres.2007.08.005
Autor:
Jan Kelder, Sjoerd F. van Aelst, Co A.M. Peters, Theo G. van Dinther, Peter D. J. Grootenhuis, A. Visser, Hans Lucas, Anton E.P. Adang, Johannes Bernardus Maria Rewinkel, D.G. Meuleman, Martin J. Smit, Adrianus Petrus Antonius De Man, G.M.T. Vogel, Constant A. A. van Boeckel
Publikováno v:
Journal of Medicinal Chemistry. 45:4419-4432
Despite intense research over the last 10 years, aided by the availability of X-ray structures of enzyme-inhibitor complexes, only very few truly orally active thrombin inhibitors have been found. We conducted a comprehensive study starting with pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b8dd5256b1dcd877b95198f2ee775e
https://doi.org/10.1021/jm011110z
https://doi.org/10.1021/jm011110z
Autor:
A Bernat, D.G. Meuleman, C. A. A. Van Boeckel, J.M. Herbert, J. P. Herault, M Petitou, J.C. Lormeau, Peter R. Hoffmann, van Rgm Amsterdam
Publikováno v:
Blood : the Journal of Hematology, 91(11), 4179-4205. American Society of Hematology
SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the “synthetic pentasaccharide” (SR 90107/ ORG 31540) which represents the antithrombin (AT) binding site of heparin. SANORG 34006 showed a higher a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a595b9874c2713ce116b1abf796b384b
https://doi.org/10.1182/blood.v91.11.4197
https://doi.org/10.1182/blood.v91.11.4197
Autor:
J. Necciari, P. Zandberg, R. Cariou, R. G. M. Van Amsterdam, Petitou Maurice, D.G. Meuleman, H.N. Magnani, J. M. Herbert, Jean-C. Lormeau, C. A. A. Van Boeckel
Publikováno v:
Cardiovascular Drug Reviews. 15:1-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7645a36348d9a7ba3c639d19ce3d4f79
https://doi.org/10.1111/j.1527-3466.1997.tb00321.x
https://doi.org/10.1111/j.1527-3466.1997.tb00321.x
Autor:
P. Zandberg, W. J. Kop, R. G. M. Van Amsterdam, P. van Houwelingen, G.M.T. Vogel, D.G. Meuleman, F. W. J. Van Mensvoort
Publikováno v:
Thrombosis and Haemostasis. 77:183-189
SummaryTwo thrombosis models in rats are described in which mixed type thrombi are formed at arterial and venous flow rates. The models, containing a silk thread in the aorta and vena cava, respectively, were characterised for the activity of three p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14728923992324131ec0c09e6714a5fa
https://doi.org/10.1055/s-0038-1655928
https://doi.org/10.1055/s-0038-1655928
Autor:
R. G. M. Van Amsterdam, J.P. He´rault, G.M.T. Vogel, D.G. Meuleman, M. Petitou, J.C. Lormeau, A. Bernat, J.M. Herbert
Publikováno v:
Circulation Research. 79:590-600
SANORG 32701 is a new sulfated pentasaccharide obtained by total chemical synthesis. It is an analogue of the “synthetic pentasaccharide” (SR 90107/ORG 31540), which represents the antithrombin III (AT-III) binding site of heparin. Like SR 90107,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecbc9071b7c42a66f674a1806028129
https://doi.org/10.1161/01.res.79.3.590
https://doi.org/10.1161/01.res.79.3.590
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 15:495-503
Abstract The synthetic pentasaccharide Org 31540/SR 90107A represents the antithrombin III (ATIII) binding region of heparin and accelerates the ATIII-mediated inhibition of coagulation factor Xa. This compound and 15 structural analogues with ATIII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3993ae80b3a7cc1aa9cf42d3404474
https://doi.org/10.1161/01.atv.15.4.495
https://doi.org/10.1161/01.atv.15.4.495
Publikováno v:
Thrombosis and Haemostasis. 69:029-034
SummaryThe mode of action of glycosaminoglycans (GAGs) towards thrombus formation in a rat arteriovenous shunt was studied by simultaneous examination of thrombus weight, platelet consumption and thrombin generation during 45 min of blood circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb87bcd8952e9e72630d6650b5f081a
https://doi.org/10.1055/s-0038-1651543
https://doi.org/10.1055/s-0038-1651543
Autor:
Hans Lucas, Jan E. M. Basten, D.G. Meuleman, Th. G. Van Dinther, C. A. A. Van Boeckel, S. F. Van Aelst
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b956dfddbc39e70430a7f3d83e7b07c9
https://doi.org/10.1002/chin.199111311
https://doi.org/10.1002/chin.199111311