Zobrazeno 1 - 10 of 79 pro vyhledávání: '"D.G. Haylett"'
1
The SK3 Subunit of Small Conductance Ca2+-activated K+ Channels Interacts with Both SK1 and SK2 Subunits in a Heterologous Expression System
Autor: David C. H. Benton, Guy W. J. Moss, Parmvir K. Bahia, Alan S. Monaghan, Ramine Hosseini, D.G. Haylett, Yousaf A. Shah
Publikováno v: Journal of Biological Chemistry. 279:1003-1009
The aim of this study was to determine whether functional heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 subunits. First, to determine whether rSK3 could co-assemble with rSK2 we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baaf560ab02e91f8c03a57ae76cebc5
https://doi.org/10.1074/jbc.m308070200
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2
K+ Currents Generated by NMDA Receptor Activation in Rat Hippocampal Pyramidal Neurons
Autor: D.G. Haylett, Mala M. Shah
Publikováno v: Journal of Neurophysiology. 87:2983-2989
Long lasting outward currents mediated by Ca2+-activated K+ channels can be induced by Ca2+ influx through N-methyl-d-aspartate (NMDA)-receptor channels in voltage-clamped hippocampal pyramidal neurons. Using specific inhibitors, we have attempted to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102d5e50ef5e0ed2723d37d2afa34bd9
https://doi.org/10.1152/jn.2002.87.6.2983
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3
Synthesis and Structure−Activity Relationships of Cetiedil Analogues as Blockers of the Ca2+-Activated K+ Permeability of Erythrocytes
Autor: M Malik-Hall, Athmani S, Wilma Quaglia, Charon Robin Ganellin, M A R Shiner, David C. H. Benton, Bisi A, D.G. Haylett, D. H. Jenkinson, Craig J. Roxburgh
Publikováno v: Journal of Medicinal Chemistry. 44:3244-3253
Cetiedil, [2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1H-azepin-1-yl)ethyl ester], which blocks the intermediate calcium-activated potassium ion permeability (IK(Ca)) in red blood cells, was used as a lead for investigating structure-activi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec387e13244d64970259c8cbdb447e6
https://doi.org/10.1021/jm001113w
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4
The pharmacology of hSK1 Ca2+-activated K+channels expressed in mammalian cell lines
Autor: Mala M. Shah, D.G. Haylett
Publikováno v: British Journal of Pharmacology. 129:627-630
The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e71114806a63c2a35ac34fcd65c8d0
https://doi.org/10.1038/sj.bjp.0703111
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6
Effects of cromakalim on the membrane potassium permeability of frog skeletal muscle in vitro
Autor: David C. H. Benton, D.G. Haylett
Publikováno v: British Journal of Pharmacology. 107:152-155
1. The effects of the potassium channel opener, cromakalim, and its active enantiomer, lemakalim, have been investigated in frog skeletal muscle. 2. Cromakalim (30-300 microM) increased 86Rb efflux from muscles loaded with the isotope, hyperpolarized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a098626b0ae6680f78b2064db7140c2f
https://doi.org/10.1111/j.1476-5381.1992.tb14478.x
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