Výsledky vyhledávání - "D.G. Grahame-Smith"

The effects of a low extracellular concentration of potassium on the activity and numbers of Na+/K+ pumps in an EB-virus transformed human lymphocyte cell line

Autor: D.G. Grahame-Smith, Jeffrey K Aronson, J G Bloomfield, D.G. Kennedy

The BM1A EB-virus transformed human lymphocyte cell line contains approximately 950 000 Na + /K + -ATPase sites per cell. The turnover number of each site is approx. 2240 molecules of rubidium per min. When cells are exposed to a low extracellular co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6c9c1053f4a7eb93e1a0acb400058a
https://doi.org/10.1016/0005-2736(90)90310-k

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Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration

Autor: T.S.C Zetterström, D.G Grahame-Smith, Q Pei

Publikováno v: Molecular Brain Research. 57:106-110

Brain-derived neurotrophic factor (BDNF) is known to modulate synaptic function as well as to promote neuronal growth in the adult brain. The aim of the present study was to compare the duration of electroconvulsive shock (ECS)-induced BDNF gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a690504b856ccbd5888fd5002b2263c5
https://doi.org/10.1016/s0169-328x(98)00077-1

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Differential effects of acute and chronic electroconvulsive shock on the abundance of messenger RNAs for voltage-dependent potassium channel subunits in the rat brain

Autor: D.G. Grahame-Smith, T.S.C Zetterström, Philip W.J. Burnet, Q Pei

Publikováno v: Neuroscience. 78:343-350

The effect of acute and chronic electroconvulsive shock on the abundance of messenger RNAs encoding voltage-dependent potassium channel subunits in the rat brain was determined by in situ hybridization histochemistry with [35S]dATP-labelled oligonucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b559a4deaf914f4c6e77be08481b6a9
https://doi.org/10.1016/s0306-4522(96)00574-x

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Evidence for presynaptic 5-hydroxytryptamine3 recognition sites on vagal afferent terminals in the brainstem of the ferret

Autor: R.A. Leslie, D.G. Grahame-Smith, David Reynolds, J.M. Harvey, P.L.R. Andrews, C. J. Davis

Publikováno v: Neuroscience. 38:667-673

Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06de471f7fa87e6c772bc0998ea72bd3
https://doi.org/10.1016/0306-4522(90)90060-h

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The effects of rubidium, caesium and quinine on 5-HT-mediated behaviour in rat and mouse--1. Rubidium

Autor: H. Wang, D.G. Grahame-Smith

Publikováno v: Neuropharmacology. 31(5)

The administration of TCP (15 mg/kg, i.p.) to rats pretreated with either intraperitoneal RbCl (3 mmol/kg, twice daily for 5 days) or dietary RbCl (30 mmol/kg diet, for 14 days), resulted in the complete 5-HT behavioural syndrome. Pretreatment with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6945cb8210d8d47bf531d96de6e94ea2
https://pubmed.ncbi.nlm.nih.gov/1382243

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The effects of rubidium, caesium and quinine on 5-HT-mediated behaviour in rat and mouse--3. Quinine

Autor: H. Wang, D.G. Grahame-Smith

Publikováno v: Neuropharmacology. 31(5)

It has been shown that caesium, which shares properties with quinine as a K(+)-channel blocker, enhanced 5-HT-mediated behaviour in both rats and mice. It was therefore of interest to investigate the effects of quinine on 5-HT-mediated behaviour in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee38d3b2bcbe2b96acc76bac23899216
https://pubmed.ncbi.nlm.nih.gov/1388254

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Effect of acute administration of L-tryptophan on the release of 5-HT in rat hippocampus in relation to serotoninergic neuronal activity: an in vivo microdialysis study

Autor: Trevor Sharp, D.G. Grahame-Smith, Steven R. Bramwell

Publikováno v: Life sciences. 50(17)

Here we have used the brain microdialysis method to test the effect of the 5-HT precursor L-tryptophan on 5-HT release. The release of endogenous 5-HT was measured in ventral hippocampus of the anesthetized rat both under basal conditions and when se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012ae6e91a87e74ceb330dd8cd9358db
https://pubmed.ncbi.nlm.nih.gov/1569829

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