Zobrazeno 1 - 10
of 44
pro vyhledávání: '"D.G. Gatehouse"'
Publikováno v:
Mutagenesis. 17:15-23
A single laser flow cytometric procedure to quantify micronucleus frequency in rat and mouse peripheral blood was evaluated. Reticulocytes express the transferrin receptor (also known as the CD71-defined antigen). When combined with a DNA stain, anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005a5ea0e750d9805bbf013ce90b3965
https://doi.org/10.1093/mutage/17.1.15
https://doi.org/10.1093/mutage/17.1.15
Publikováno v:
Journal of Biological Chemistry. 274:18319-18326
The endogenous formation of N-nitrosoindoles is of concern since humans are exposed to a variety of naturally occurring and synthetic indolic compounds. As part of a study to evaluate the genotoxicity of N-nitrosoindoles, the reactions of three model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884185369782780aaac6240cf29fe8d8
https://doi.org/10.1074/jbc.274.26.18319
https://doi.org/10.1074/jbc.274.26.18319
Autor:
D.B. Morton, P.A. Botham, R.J. Fielder, D.G. Gatehouse, David Kirkland, D.J. Esdaile, Alan R. Boobis, M. Richold, J.A. Allen, J. Doe, G. Hodson-Walker
Publikováno v:
Scopus-Elsevier
The BTS/UKEMS Working Group was established to consider dose selection for in-vivo mutagenicity assays, and the feasibility of establishing criteria for identifying maximum dose levels that did not involve relating these to a high fraction (50-80%) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb499cc1c5de02ab8cb63a3e706530e9
https://doi.org/10.1177/096032719301200301
https://doi.org/10.1177/096032719301200301
Publikováno v:
Mutagenesis. 8:93-100
A collaborative trial was carried out to determine the intra/interlaboratory variability of Salmonella typhimurium strains TA102 and TA97a with regard to spontaneous revertant frequency and in response to four model mutagens (cumene hydroperoxide and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ba5e58beacedb1ed330348da3b7c01
https://doi.org/10.1093/mutage/8.2.93
https://doi.org/10.1093/mutage/8.2.93
Publikováno v:
Mutagenesis. 8:167-174
The number and structural diversity of new compounds that are currently being introduced into the environment underlies the need to provide more sensitive toxicology tests. Ideally, these should involve tests that reduce dependence upon animal experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a845c3dbc4f8848337fb00239b3690
https://doi.org/10.1093/mutage/8.3.167
https://doi.org/10.1093/mutage/8.3.167
Autor:
David Kirkland, D.G. Gatehouse
Publikováno v:
Cancer Risk Assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbbf9f2015e9a9efd45b3023de26acca
https://doi.org/10.1002/9780470622728.ch11
https://doi.org/10.1002/9780470622728.ch11
Autor:
D.B. Morton, D.J. Esdaile, P.A. Botham, G. Hodson-Walker, Alan R. Boobis, D.G. Gatehouse, David Kirkland, J.A. Allen, R.J. Fielder, J. Doe, M. Richold
Publikováno v:
Mutagenesis. 7:313-319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d808c98abbe33ee85549faa7f3d6e484
https://doi.org/10.1093/mutage/7.5.313
https://doi.org/10.1093/mutage/7.5.313
Publikováno v:
Mutagenesis. 6:11-18
The H2-antagonist loxtidine and the H+/K(+)-ATPase inhibitor omeprazole inhibit gastric acid secretion and both have been associated with the appearance of gastric tumours in rat cancer studies. Loxtidine is not genotoxic in a range of in vitro and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c795fa549201f107b4565ecb714c8
https://doi.org/10.1093/mutage/6.1.11
https://doi.org/10.1093/mutage/6.1.11
Publikováno v:
Mutagenesis. 20(1)
Lanthanum was evaluated for potential genotoxicity using a range of in vitro assays (as the carbonate) in the presence and absence of post-mitochondrial fraction (S9) and in vivo in three independent tests for mutagenicity and clastogenicity (as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32108837868b73d88a08f0eead5cf576
https://pubmed.ncbi.nlm.nih.gov/15625069
https://pubmed.ncbi.nlm.nih.gov/15625069
Autor:
George Bolcsfoldi, Lynnette R. Ferguson, D.G. Gatehouse, Philip R. Harbach, Anne H. Illi-Love, Marek Lenarczyk, Veerle Van Hoof, Nikki E. Hall, Dennis D. Broud, Carol R. Tometsko, Shuou Zhao, James P. McNamee, Stephen D. Dertinger, Dean R. Hewish, Amira Pearson, Carol W. Johnson, Monique Parenteau, Brenda E. Rodgers, James P. Tarca, Larissa Doughty, Jenness B. Majeska, Karin Cederbrant, Anthony M. Lynch, Kerstin Sandelin, Dorothea K. Torous, James L. Weaver, Philippe Vanparys, Marilyn S. Diehl, J. R. N. McLean, C.S. Aaron, Bogumiła Litwińska, Michael Fenech, Puntipa Kwanyuen, Joanna Siennicka, Ian C. Marshall, Maria G. Slowikowska, Geoffrey M. Hynes
Publikováno v:
Environmental and molecular mutagenesis. 38(1)
This laboratory previously described a single-laser flow cytometric method, which effectively resolves micronucleated erythrocyte populations in rodent peripheral blood samples. Even so, the rarity and variable size of micronuclei make it difficult t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabb1143a4f78fe3910b525f0fcffc64
https://pubmed.ncbi.nlm.nih.gov/11473389
https://pubmed.ncbi.nlm.nih.gov/11473389