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Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations

Autor: R. Jones, D.F. Woodward, Jenny W. Wang, Rachel L. Clark

Publikováno v: British Journal of Pharmacology. 162:863-879

The highly lipophilic acyl-sulphonamides L-798106 and L-826266 showed surprisingly slow antagonism of the prostanoid EP3 receptor system in guinea-pig aorta. Roles of affinity and lipophilicity in the onset kinetics of these and other prostanoid liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0dd6b4cab5a0cd921af820cdc9b067c
https://doi.org/10.1111/j.1476-5381.2010.01087.x

Characterization of anin vivomodel for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost

Autor: D.F. Woodward, Elke Lütjen-Drecoll, Ralf Paus, T. A. Fuchs, Miyuki Tauchi, A.J. Kellenberger

Publikováno v: British Journal of Dermatology. 162:1186-1197

BACKGROUND: Hypertrichosis or alopecia of the eyelashes is associated with various diseases or may be drug induced. Although neither increase nor loss of eyelashes is life threatening, eyelash disorders can be psychologically disturbing. However, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::251f567107a68253cf5f7d71bcc96236
https://doi.org/10.1111/j.1365-2133.2010.09685.x

Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes

Autor: Victor M. Guzman, D.F. Woodward, C. L. Cornell, Jenny W. Wang, D. F. Scott, K Landsverk, Hans G. Fliri, Simon N. Pettit, Yanbin Liang, A H-P Krauss, Chen Li, Jose L. Martos, M. E. Garst, Larry A. Wheeler, Gary S. Sachs

Publikováno v: British Journal of Pharmacology. 154:1079-1093

Background and purpose: A prostamide analogue, bimatoprost, has been shown to be effective in reducing intraocular pressure, but its precise mechanism of action remains unclear. Hence, to elucidate the molecular mechanisms of this effect of bimatopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9721d2272d73246edcde20bb2c95cb7c
https://doi.org/10.1038/bjp.2008.142

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration

Autor: V. Di Marzo, Jenny W. Wang, A.L. Nieves, D.F. Woodward, I. Matias, A. Schiano Moriello

Publikováno v: 75 (2006): 413–418.
info:cnr-pdr/source/autori:I. Matias, J.W. Wang, A. Schiano Moriello, A. Nieves, D. F. Woodward, V. Di Marzo/titolo:Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration/doi:/rivista:/anno:2006/pagina_da:413/pagina_a:418/intervallo_pagine:413–418/volume:75

Cannabinoid receptors and the endocannabinoids (anandamide (N-arachidonoylethanolamine--AEA) and 2-arachidonoylglycerol (2-AG)), as well as the AEA congener, palmitoylethanolamide (PEA), are involved in ocular physiology. We measured endocannabinoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d632f3edb9ea5609c2b3771ebf87bde7
https://doi.org/10.1016/j.plefa.2006.08.002