Zobrazeno 1 - 10
of 71
pro vyhledávání: '"D.B Rylatt"'
Publikováno v:
Journal of Chromatography A. 827:329-335
Four monoclonal antibodies (including Ig subclasses, G1, G2a, and G2b) were purified from murine ascitic fluid by a preparative electrophoresis system using a charge- and size-based strategy. Most of the smaller contaminating proteins were removed at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb655858c9b5f61683e39419923efe33
https://doi.org/10.1016/s0021-9673(98)00847-4
https://doi.org/10.1016/s0021-9673(98)00847-4
Publikováno v:
Immunology and Cell Biology. 71:117-124
The antifibrin DD-3B6/22 monoclonal antibody Fab' fragment, a murine immunoglobulin, IgG3, has been labelled with technetium-99 m (99mTc) via a transchelation reaction, to specific activity in excess of 30 mCi/mg protein. The radiolabelling of Fab' w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7d893f2885f8a42b2a8d9ffad0b45e
https://doi.org/10.1038/icb.1993.12
https://doi.org/10.1038/icb.1993.12
Autor:
P.G. Bundesen, G.R. Boniface, L. J. Milner, A. R. J. Weedon, K. Z. Walker, Fook-Thean Lee, George J. Bautovich, D.B. Rylatt
Publikováno v:
Immunology and Cell Biology. 70:173-179
Technetium-99 m (99mTc)-labelled conjugates of an anti-fibrin monoclonal antibody, DD-3B6/22, have been assessed for their detection of vascular thrombi in a rabbit model. DD-3B6/22 binds to a D-dimer epitope present on cross-linked fibrin but absent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a142446e86804f3caccd678144da9da0
https://doi.org/10.1038/icb.1992.22
https://doi.org/10.1038/icb.1992.22
Publikováno v:
Thrombosis Research. 58:273-281
A new system for the detection of fibrin degradation products in whole blood has been developed. The test provides a clearly visible agglutination of the patient's red blood cells in the presence of elevated levels of the crosslinked fibrin derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6ab3c94d3780fd4c20bffeaaa14059
https://doi.org/10.1016/0049-3848(90)90097-v
https://doi.org/10.1016/0049-3848(90)90097-v
Publikováno v:
Fibrinolysis. 10:5
The effectiveness of anticoagulant therapy is limited by the inability of many anticoagulant molecules to inhibit completely clot bound thrombin. Despite the development of direct, potent thrombin inhibitors such as hirudin, there remains significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0be36d1b78c7d123611992784f8c5059
https://doi.org/10.1016/s0268-9499(96)80775-2
https://doi.org/10.1016/s0268-9499(96)80775-2
Publikováno v:
Thrombosis and Haemostasis. 50:591-594
SummaryWe have prepared a monoclonal antibody which recognises an antigenic determinant on D dimer, a specific fragment resulting from the degradation of crosslinked fibrin. This antibody has been used in the development of an enzyme-linked immunoass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d44568fba5418b7631e473abf47d45c7
https://doi.org/10.1055/s-0038-1665263
https://doi.org/10.1055/s-0038-1665263
Measurement of cross linked fibrin derivatives in plasma: an immunoassay using monoclonal antibodies
Publikováno v:
Journal of Clinical Pathology. 37:882-887
Fibrinogen degradation, fibrin polymerisation, and the insertion of cross links into fibrin by fibrin stabilising factor lead to the appearance of new antigenic determinants. Antibodies against these antigenic sites may react specifically with the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f40f0a3e3811e8bd5cd754f62a71d02
https://doi.org/10.1136/jcp.37.8.882
https://doi.org/10.1136/jcp.37.8.882
Autor:
D. Wyatt, Paul P. Masci, D.B. Rylatt, A.S. Blake, I H Bunce, A.N. Whitaker, M J Elms, W.A. Fletcher, D.A. Massingham, P.G. Bundesen, L.E. Cottis, A.J. Webber
Publikováno v:
Thrombosis Research. 31:767-778
Monoclonal antibodies (MAb) were raised against human D dimer. The hybridomas were screened with a solid phase enzyme immunoassay against D dimer and fibrinogen degradation products. Among the panel of MAb identified, two distinct patterns emerged; t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b503d572f0c1323aa8d5e2264af681a
https://doi.org/10.1016/0049-3848(83)90108-1
https://doi.org/10.1016/0049-3848(83)90108-1
Publikováno v:
Thrombosis Research. 52:269-278
The D Dimer (DD) site formed by linkage of D domains from adjacent fibrin (FN) molecules is unique to cross-linked FN and its degradation products and is not found in FN monomer or fibrinogen (FB). Thus monoclonal antibodies (MAb) reactive to DD shou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a318a70bb2de7777e240e6cac8a9c8e
https://doi.org/10.1016/0049-3848(88)90068-0
https://doi.org/10.1016/0049-3848(88)90068-0
Autor:
A.N. Whitaker, I H Bunce, P G Bundesen, K Lee, P Reasbeck, J McCaffrey, Paul P. Masci, BJ Rowbotham, A.J. Webber, F Wylie, D.B. Rylatt, SM Guerrini, M J Elms
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
The presence of XLFDP in plasma, a consequence of the balance between fibrin generation and dissolution, is an indirect index of the presence of fibrin and raised levels accompany intravascular thrombosis. The potential of an enzyme immunoassay (EIA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be00292e58f1dec46d968dceb3ee6b38
https://doi.org/10.1055/s-0038-1643650
https://doi.org/10.1055/s-0038-1643650