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Expression of the two insulin receptor isoforms is not altered in the skeletal muscle and liver of diabetic rats

Autor: M. D'Adamo, Andrea Giaccari, A. Buongiorno, S. Caiola, G. Tamburrano, L. Morviducci, E. Maroccia, Paolo Sbraccia, D. Zorretta

Publikováno v: Metabolism. 47:129-132

Alternative splicing of the 36-base pair exon 11 of the human insulin receptor (IR) gene and of the corresponding domain of the rat IR gene results in the synthesis of two IR isoforms with distinct functional characteristics. Altered expression of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbea31a8e5b143f76a5ae9c52bb2dc5
https://doi.org/10.1016/s0026-0495(98)90207-4

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Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia

Autor: L. Morviducci, L. Pastore, Andrea Giaccari, G. Tamburrano, A. Buongiorno, D. Zorretta, Paolo Sbraccia, E. Maroccia

Publikováno v: Diabetologia. 41(3)

Several studies have suggested that, in non-insulin-dependent diabetes mellitus, augmented gluconeogenesis is responsible for increased endogenous glucose production (EGP) and in the end determines fasting hyperglycaemia. However, human and animal st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959d5c8a45ccb906dc3cbcd9e3682c8b
https://pubmed.ncbi.nlm.nih.gov/9541171

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Increased OB gene expression leads to elevated plasma leptin concetrations in patients with chronic primary hyperinsulinemia

Autor: D. Zorretta, E. Maroccia, A. Buongiorno, Guido Tamburrano, Fabrizio Barbetti, Andrea Giaccari, Monica D’Adamo, Frida Leonetti, Paolo Sbraccia

Leptin, a hormone secreted by adipocytes, decreases food intake and increases energy expenditure. The role of insulin in the regulation of leptin secretion is poorly understood and is still a topic of debate. Insulin increases leptin mRNA synthesis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ac9d02869264be7c3c2a697426fa53
http://hdl.handle.net/2108/228311

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In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia

Autor: Frida Leonetti, Andrea Giaccari, G. Tamburrano, Stefania Caiola, A. Buongiorno, Riccardo C. Bonadonna, D. Zorretta, L. Morviducci, P. Sbraccia

We tested the hypothesis that glucosamine, a putative activator of glucose toxicity in vitro through acceleration of the hexosamine pathway, may determine in vivo the two key features of glucose toxicity in diabetes, namely, peripheral insulin resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7eb1b544ec9c275da846e5732d09291
http://hdl.handle.net/11562/434893

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Regulation of rat insulin receptor tyrosine kinase by hypoglycemia

Autor: D. Zorretta, Paolo Sbraccia, S Caiola, Guido Tamburrano, Monica D’Adamo, A. Buongiorno, Andrea Giaccari, L. Morviducci, Frida Leonetti

To investigate the effect of hypoglycemia on the regulation of muscle-derived insulin receptor tyrosine kinase activity, four groups of Sprague-Dawley rats were studied: two groups in which either insulin (4 mU/kg.min) or phloridzin (3 mg/kg.min) was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe74f6c164a7a8315c7f639a01bcd08
http://hdl.handle.net/11573/783201

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Idiopathic reactive hypoglycemia: a role for glucagon?

Autor: L. Morviducci, D. Zorretta, Paolo Sbraccia, Frida Leonetti, Stefania Caiola, Guido Tamburrano, Andrea Giaccari, O. Lostia

Publikováno v: Journal of endocrinological investigation. 15(4)

We previously reported that patients with idiopathic reactive hypoglycemia (plasma glucose concentration lower than 2.5 mmol/L 2-4 h after the ingestion of 75 g of glucose) display reduced or absent counterregulatory response of the glucagon secretio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f476392c46d69a59e95692f755cc43
https://pubmed.ncbi.nlm.nih.gov/1512417

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Insulin secretion in children with growth retardation

Autor: E. Rezza, G. Mancuso, A. M. Pasquino, O. Lostia, P. Montani, Brunetto Boscherini, D. Zorretta, J. Rocchio, F. Taggi, G. Finocchi

Publikováno v: European Journal of Pediatrics. 127:21-26

The effect of tolbutamide administration on insulin secretion was studied in 69 children with growth retardation. Diminished insulin secretion was found in all the patients, compared to the control group. This insulin deficit was most evident in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f691232492a72ca2d020296c9617ab
https://doi.org/10.1007/bf00465562

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