Výsledky vyhledávání - "D. Ya. Havrylyuk,"

Akademický článek

4-Thiazolidinone-based derivatives rescue TNAα-inhibited osteoblast differentiation in mouse mesenchymal precursor cells

Autor: Kh. V. Malysheva, N. S. Finiuk, O. K. Pavlenko, D. Ya. Havrylyuk,, R. B. Lesyk, R. S. Stoika, O. G. Korchynskyi

Publikováno v: The Ukrainian Biochemical Journal, Vol 89, Iss SI01, Pp 111-122 (2017)

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease of yet unknown etiology. Tumor necrosis factor α (TNFα) is recognized as a regulatory substance that plays a central role in RA development and progression. On the other side, the bone

Externí odkaz: https://doaj.org/article/cb4e3b20ae71473b973cecfb8449c47e

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Akademický článek

Biochemical indicators of hepatotoxicity in blood serum of rats under the effect of novel 4-thiazolidinone derivatives and doxorubicin and their complexes with polyethyleneglycol-containing nanoscale polymeric carrier

Autor: L. I. Kоbylinska, D. Ya. Havrylyuk, А. О. Ryabtseva, N. E. Mitina, О. S. Zаichenko, R. B. Lesyk, B. S. Zіmenkovsky, R. S. Stoika

Publikováno v: The Ukrainian Biochemical Journal, Vol 87, Iss 2, Pp 122-132 (2015)

The aim of this study was to compare the effect of new synthetic 4-tiazolidinone derivatives (compounds 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyethyleneglycol-containing nanoscale

Externí odkaz: https://doaj.org/article/535dc5db2a9149439e6172359ecad216

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Akademický článek

VITALITY AND MORPHOLOGY OF TUMOR CELLS TREATED WITH 4-TIAZOLIDINONE DERIVATIVES IMMOBILIZED ON NANOSCALE POLYMER CARRIER

Autor: N. M. Boiko, O. Yu. Klyuchivska, L. I. Коbylinska, D. Ya. Havrylyuk, A. O. Ryabtseva, N. Ye. Mitina, R. B. Lesyk, O. S. Zаichenko, R. S. Stoika

Publikováno v: Biotechnologia Acta, Vol 8, Iss 1, Pp 39-48 (2015)

A nanoscale polymeric carrier was used for delivery of novel anticancer compounds – 4-tiazolidinone derivatives – to tumor cells of different lines. It was found that such way of delivery of the above mentioned compounds to target cells significa

Externí odkaz: https://doaj.org/article/b26f9f4f109348758735d23cf6e44049

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Akademický článek

Comparative study of the cytotoxic properties of isatin-containing derivatives of 4-thiazolidinone with different structure toward human tumor cells in vitro

Autor: V. V. Chumak, R. R. Panchuk, N. O. Manko, D. Ya. Havrylyuk, R. V. Lesyk, L. I. Kobylinska, B. S. Zimenkovsky, R. S. Stoika

Publikováno v: Біологічні студії, Vol 8, Iss 2, Pp 29-42 (2014)

Compounds on the basis of 4-thiazolidinone and its isatin-containing derivatives are characterized by a broad spectrum of biological activities and are potential antineoplastic agents. We have shown that the combination of 4-thiazolidinone and isatin

Externí odkaz: https://doaj.org/article/6b94ba341ffa4a289115694e01d4b178

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4-Thiazolidinone-based derivatives rescue TNAα-inhibited osteoblast differentiation in mouse mesenchymal precursor cells

Autor: N. S. Finiuk, O. G. Korchynsky, O. K. Pavlenko, Kh. V. Malysheva, Rostyslav Stoika, Roman Lesyk, D. Ya. Havrylyuk

Publikováno v: Ukrainian Biochemical Journal, Vol 89, Iss SI01, Pp 111-122 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7c32341904b51db4ff170f177ea2bd
https://doi.org/10.15407/ubj89.si01.111

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Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier

Autor: Nataliya Mitina, L I Kоbyli nska, Alexander Zaichenko, B S Zіme nkovsky, Rostyslav Stoika, D. Ya. Havrylyuk, Roman Lesyk

Publikováno v: Ukrainian Biochemical Journal, Vol 88, Iss 1, Pp 51-60 (2016)

The aim of this study was to compare the effect of new synthetic 4-thiazolidinone derivatives (potential anticancer compounds denoted as 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59054e49a74bfabd95d2dc5b000a1594
https://pubmed.ncbi.nlm.nih.gov/29227079

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Synthesis of new pyrazoline-thiazoles and their biological activity

Autor: D. Ya. Havrylyuk

Publikováno v: Journal of Organic and Pharmaceutical Chemistry. 12:59-64

The application of the [2+3]-cyclocondensation reaction for the synthesis of 2-pyrazoline substituted thiazolidinones, as well as bioisosteric pyrazoline-thiazoles has been analyzed. Following the literature data 4,5-dihydro- 1-carbothioamides are us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d27d3cea9dcaa328b321212c31d2a7e0
https://doi.org/10.24959/ophcj.14.797

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