Zobrazeno 1 - 10
of 386
pro vyhledávání: '"D. Witham"'
Autor:
Shaun Treweek, Katie Gillies, Miles D. Witham, Declan Devane, Kamlesh Khunti, Peter Bower, Adwoa Parker, Irene Soulsby, Bārbala Ostrovska, Sarah Prowse, Heidi Green
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background The benefits of randomised trials are not shared equally, and people from ethnic minority groups are a key constituency under-served by clinical research and clinical care. The STRIDE project aimed to give trialists practical info
Externí odkaz:
https://doaj.org/article/029524d9239c4b0786b078687195406e
Autor:
Christopher Hurst, Lorelle Dismore, Antoneta Granic, Jane M. Noble, Susan J. Hillman, Miles D. Witham, Avan A. Sayer, Richard M. Dodds, Sian M. Robinson
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Older adults living with multiple long-term conditions (MLTC, also known as multimorbidity) and frailty are more likely to experience a deterioration in their health requiring specialist referral or hospital admission than individ
Externí odkaz:
https://doaj.org/article/d54c4629cb40484faec61335f53f3504
Autor:
Miles D Witham, Rachel Cooper, Antoneta Granic, Avan A Sayer, Susan J Hillman, Richard M Dodds
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Objectives This study aims to determine whether machine learning can identify specific combinations of long-term conditions (LTC) associated with increased sarcopenia risk and hence address an important evidence gap—people with multiple LTC (MLTC)
Externí odkaz:
https://doaj.org/article/f6654ab1d7424b7a8bd388f943b05e95
Autor:
Sue Bellass, Thomas Scharf, Linda Errington, Kelly Bowden Davies, Sian Robinson, Adam Runacres, Jodi Ventre, Miles D. Witham, Avan A. Sayer, Rachel Cooper
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Background Multiple long-term conditions—the co-existence of two or more chronic health conditions in an individual—present an increasing challenge to populations and healthcare systems worldwide. This challenge is keenly felt in hospita
Externí odkaz:
https://doaj.org/article/5a9a12a55c1d433998b350760fb98a74
Autor:
Christopher Hurst, Lorelle Dismore, Antoneta Granic, Ellen Tullo, Jane M. Noble, Susan J. Hillman, Miles D. Witham, Avan A. Sayer, Richard M. Dodds, Sian M. Robinson
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Many older adults live with the combination of multiple long-term conditions (MLTC) and frailty and are at increased risk of a deterioration in health requiring interaction with healthcare services. Low skeletal muscle strength is
Externí odkaz:
https://doaj.org/article/6eb04b2fd0cf43d1a12cb52a63db4204
Autor:
Miles D Witham, Lynn Rochester, Charlotte Warren, Laura Brown, Claire McDonald, Silvia Del Din, Kieren Hollingsworth, Craig Alderson, Matthew G Birkbeck, Grainne G Gorman, Clare Massarella, Rana Rehman, Avan AP Sayer, Huizhong Su, Helen Tuppen
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Sarcopenia is the age-associated loss of muscle mass and strength. Nicotinamide adenine dinucleotide (NAD) plays a central role in both mitochondrial function and cellular ageing processes implicated in sarcopenia. NAD concentrations are
Externí odkaz:
https://doaj.org/article/93100a3755a34152b4561225feeb19b5
Autor:
Tom Marshall, Elizabeth Sapey, Miles D Witham, Steve Harris, Rachel Cooper, Chris Plummer, Felicity Evison, James Wason, Heather J Cordell, Suzy Gallier, Fiona E Matthews, Ewan Pearson, Avan A Sayer, Mervyn Singer, Joanne Field, Mohammed Osman, Sian Robinson, Victoria Bartle, Thomas Scharf, Jadene Lewis, Rominique Doal, Peta le Roux, Ray Holding, Paolo Missier
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Objectives Analysis of routinely collected electronic health data is a key tool for long-term condition research and practice for hospitalised patients. This requires accurate and complete ascertainment of a broad range of diagnoses, something not al
Externí odkaz:
https://doaj.org/article/703b51a843cb4454bc461a458024a6fe
Autor:
Alvin Shrestha, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Avan A Sayer, Christos Rossios, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0307268 (2024)
IntroductionUnderstanding genetic contributors to sarcopenia (age-related loss of muscle strength and mass) is key to finding effective therapies. Variants of the bradykinin receptor 2 (BDKRB2) have been linked to athletic and muscle performance. The
Externí odkaz:
https://doaj.org/article/729f9642b39144fe86a84ce912c50d84
Autor:
Oscar Flores-Flores, Alejandro Zevallos-Morales, Suzanne L. Pollard, William Checkley, Trishul Siddharthan, John R. Hurst, Antonio Bernabé-Ortiz, Fernando M. Runzer-Colmenares, Miles D. Witham, Jose F. Parodi
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/3d7668597f3949baa13c363dcfe4940b
Autor:
Felicity Evison, Rachel Cooper, Suzy Gallier, Paolo Missier, Avan A. Sayer, Elizabeth Sapey, Miles D. Witham
Publikováno v:
ERJ Open Research, Vol 9, Iss 5 (2023)
Introduction Respiratory specialist ward care is associated with better outcomes for patients with COPD exacerbations. We assessed patient pathways and associated factors for people admitted to hospital with COPD exacerbations. Methods We analysed ro
Externí odkaz:
https://doaj.org/article/df974685551c422695e4e7e5e8a05ddf