Výsledky vyhledávání - "D. Wickenden"

Akademický článek

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers.

Autor: Wai-Ping Fung-Leung, Wilson Edwards, Yi Liu, Karen Ngo, Julianty Angsana, Glenda Castro, Nancy Wu, Xuejun Liu, Ronald V Swanson, Alan D Wickenden

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170102 (2017)

Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T cells during activation results in reduced calcium entry, cytokine

Externí odkaz: https://doaj.org/article/03c72e4681be4f49b4826d4affe70981

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Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides

Autor: Alan D. Wickenden, Robert A. Neff

Publikováno v: Channels
article-version (VoR) Version of Record

A fundamental mechanism that drives the propagation of electrical signals in the nervous system is the activation of voltage-gated sodium channels. The sodium channel subtype Nav1.7 is critical for the transmission of pain-related signaling, with gai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8f759cd24189d37825a71ecfd021fb
https://doi.org/10.1080/19336950.2020.1860382

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A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)

Autor: Kelly L. Damm-Ganamet, Alan D. Wickenden, Taraneh Mirzadegan, Marie-Laure Rives, Heather M. McAllister

Publikováno v: J Biol Chem

Excitatory amino acid transporters (EAATs) represent a protein family that is an emerging drug target with great therapeutic potential for managing central nervous system disorders characterized by dysregulation of glutamatergic neurotransmission. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d110c0bb332f0e5ce669aeea4b3a2edf
https://doi.org/10.1074/jbc.ac119.011190

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7

Autor: Amy Y. Shih, Ondrej Libiger, Stephanie Young, Alan Gibbs, Alan D. Wickenden, Michael J. Hunter, Ross Fellows, Yi Liu, Robert A. Neff, Michael W. Pennington, Natali A. Minassian, Mack Flinspach

Publikováno v: Journal of Biological Chemistry. 295:1315-1327

Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Nav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b3333971182bd93835c976bcc0d6718
https://doi.org/10.1074/jbc.ra119.011318

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Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties

Autor: James Limberis, Daniel Knowland, Anindya Bhattacharya, William A. Eckert, Alan D. Wickenden, Shenyan Gu, David S. Bredt, Jose A. Matta, G. Brent Dawe

Publikováno v: J Clin Invest

The α6β4 nicotinic acetylcholine receptor (nAChR) is enriched in dorsal root ganglia neurons and is an attractive non-opioid therapeutic target for pain. However, difficulty expressing human α6β4 receptors in recombinant systems has precluded dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f464fbb456e637e38b2ed016a2e6e25d
https://pubmed.ncbi.nlm.nih.gov/33074245

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa

Autor: Robert A, Neff, Mack, Flinspach, Alan, Gibbs, Amy Y, Shih, Natali A, Minassian, Yi, Liu, Ross, Fellows, Ondrej, Libiger, Stephanie, Young, Michael W, Pennington, Michael J, Hunter, Alan D, Wickenden

Publikováno v: J Biol Chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a7d71b7a0b75aaac86abe5aa31806d9
https://pubmed.ncbi.nlm.nih.gov/31871053

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The discovery and preclinical characterization of 6-chloro- N -(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists

Autor: Alec D. Lebsack, Alan D. Wickenden, Sandra R. Chaplan, Qi Wang, Jason C. Rech, Love Christopher John, William A. Eckert, J. Guy Breitenbucher, Ludwig Paul Cooymans, Leenaerts Joseph Elisabeth, Anindya Bhattacharya, Bryan James Branstetter, Hong Ao

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:4781-4784

The synthesis, SAR and preclinical characterization of a series of 6-chloro- N -(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists is described herein. The lead compounds are pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388b93925ee3e02bc3395487919b3389
https://doi.org/10.1016/j.bmcl.2016.08.029

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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP- 8

Autor: Thomas Steckler, Michael K. Ameriks, Suchitra Ravula, Christine Dugovic, Luc Ver Donck, Alan D. Wickenden, Changlu Liu, Timothy W. Lovenberg, Nicholas I. Carruthers, Brian Lord, Nyantsz Wu, Sujin Yun, Jose A. Matta, Ryan M Wyatt, Brad M. Savall, Michael P. Maher

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 357:394-414

Members of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA) subtype of ionotropic glutamate receptors mediate the majority of fast synaptic transmission within the mammalian brain and spinal cord, representing attractive targets for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7488b566cf60907bc2c6f463cd532b87
https://doi.org/10.1124/jpet.115.231712

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