Zobrazeno 1 - 10
of 142
pro vyhledávání: '"D. Welford"'
Autor:
Peter Blattmann, Hervé Farine, Brian Dan, Nicole Stiffler, Thomas Lefebvre, Christine Huynh, Patricia N. Sidharta, Jasper Dingemanse, Richard W. D. Welford, Marcel Keller, Daniel S. Strasser
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract CXCL12 acts as a chemoattractant by binding to the receptor CXCR4. The (atypical) chemokine receptor ACKR3 (CXCR7) scavenges CXCL12. Antagonism of ACKR3 thus leads to an increase in CXCL12 concentrations that has been used as a pharmacodynam
Externí odkaz:
https://doaj.org/article/e53b8c21584147f092daf12cfbcb0485
Autor:
Patrick Sieber, Anny Schäfer, Raphael Lieberherr, François Le Goff, Manuel Stritt, Richard W D Welford, John Gatfield, Oliver Peter, Oliver Nayler, Urs Lüthi
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207872 (2018)
Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α-smooth muscle actin (α-SMA)-expressing myofibroblasts that produce and secrete ECM
Externí odkaz:
https://doaj.org/article/015179c2a49047e79610cca7f51ef289
Autor:
Patricia N. Sidharta, Martine Gehin, Jasper Dingemanse, Meggane Melchior, Richard W. D. Welford
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 558-567 (2021)
Clinical and Translational Science
Clinical and Translational Science
In this first-in-human study, the tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of sinbaglustat, a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2), were
Autor:
Richard W D Welford, Marco Garzotti, Charles Marques Lourenço, Eugen Mengel, Thorsten Marquardt, Janine Reunert, Yasmina Amraoui, Stefan A Kolb, Olivier Morand, Peter Groenen
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114669 (2014)
Niemann-Pick disease type C (NP-C) is a devastating, neurovisceral lysosomal storage disorder which is characterised by variable manifestation of visceral signs, progressive neuropsychiatric deterioration and premature death, caused by mutations in t
Externí odkaz:
https://doaj.org/article/097308444a9c4c36986235836a84feac
Autor:
Richard W. D. Welford, Agata Sebastian, Alexander Schmidt, Daniel S. Strasser, Marcel P Keller, Lukasz Kozera, Hervé Farine
Publikováno v:
Journal of proteome research. 19(10)
One of the most important advantages of mass spectrometry is the ability to quantify proteins and their modifications in parallel to obtain a holistic picture of the protein of interest. Here, we present a hybrid immunoaffinity targeted mass spectrom
Autor:
François Lehembre, Benedicte Haenig, Elise Simon, Daniela Sabato, Julie Erupathil, Matthias Gstaiger, Imke Renz, Lhéanna Klaeylé, Meenhard Herlyn, Patricia Brafford, Richard W. D. Welford, Min Xiao, Panja Strickner, Alexander Schäfer, Clemens Krepler
Publikováno v:
Oncogene. 40(9)
The clinical benefit of MAPK pathway inhibition in melanoma patients carrying BRAF mutations is temporal. After the initial response to treatment, the majority of tumors will develop resistance and patients will relapse. Here we demonstrate that the
Autor:
Imke Renz, Francois Lehembre, Enio Gjerga, Peter M.A. Groenen, Alexander Schäfer, Richard W. D. Welford, Ruedi Aebersold, Julio Saez-Rodriguez, Matthias Gstaiger
Publikováno v:
Molecular Systems Biology, 15 (8)
Molecular systems biology 15(8), e8828 (2019). doi:10.15252/msb.20198828
Molecular Systems Biology, Vol 15, Iss 8, Pp n/a-n/a (2019)
Molecular Systems Biology
Molecular systems biology 15(8), e8828 (2019). doi:10.15252/msb.20198828
Molecular Systems Biology, Vol 15, Iss 8, Pp n/a-n/a (2019)
Molecular Systems Biology
Endothelins (EDN) are peptide hormones that activate a GPCR signalling system and contribute to several diseases, including hypertension and cancer. Current knowledge about EDN signalling is fragmentary, and no systems level understanding is availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f5c26f717ca10fdb69999eba18a138
Autor:
Maria Josep Coll, Philippe Latour, Cyril Goizet, Marie T. Vanier, Thorsten Marquardt, Paul Gissen, Christian J. Hendriksz, Alberto Burlina, Peter Bauer, Richard W. D. Welford, Stefan A. Kolb
Publikováno v:
Molecular Genetics and Metabolism. 118(4):244-254
Niemann-Pick disease type C (NP-C) is a neurovisceral lysosomal cholesterol trafficking and lipid storage disorder caused by mutations in one of the two genes, NPC1 or NPC2. Diagnosis has often been a difficult task, due to the wide range in age of o
Autor:
Richard W. D. Welford, Patricia N. Sidharta, Oliver Nayler, Martine Gehin, Peter M.A. Groenen, Marco Garzotti, Magali Vercauteren, Jasper Dingemanse
Publikováno v:
Clinical pharmacology and therapeutics. 104(6)
Serotonin (5-HT) is synthesized from dietary tryptophan (Trp) and plays an important role in numerous diseases of the central nervous system and periphery. Stable isotope tracers enable safe monitoring of metabolic rates. Here we demonstrate measurem
Autor:
Richard W. D. Welford, Jasper Dingemanse, Daniel Oder, Nicolas Guérard, Christian Zwingelstein, Peter Nordbeck, Olivier Morand, Christoph Wanner
Publikováno v:
Clinical pharmacology and therapeutics. 103(4)
Lucerastat is a glucosylceramide synthase inhibitor aimed at reducing production of glycosphingolipids (GSLs), including those accumulating in Fabry disease. The safety, tolerability, pharmacodynamics, and pharmacokinetics of oral lucerastat were eva