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Akademický článek

The Size and Emergence of Geochemical Heterogeneities in the Hawaiian Mantle Plume Constrained by Sr‐Nd‐Hf Isotopic Variation Over ∼47 Million Years

Autor: L. N. Harrison, D. Weis

Publikováno v: Geochemistry, Geophysics, Geosystems, Vol 19, Iss 8, Pp 2823-2842 (2018)

Abstract The Hawaiian‐Emperor chain is the ∼6,000 km long surface expression of the deeply sourced Hawaiian mantle plume active over the past ∼81 Myr. The Hawaiian Islands (81–47 Ma) show only Kea compositions. New Sr‐Nd‐Hf isotope, trace

Externí odkaz: https://doaj.org/article/62bcd37af73e49afb9ff3f38a553081d

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Akademický článek

The Pelona-Pico Duarte basalts Formation, Central Hispaniola: an on-land section of Late Cretaceous volcanism related to the Caribbean large igneous province

Autor: J. ESCUDER VIRUETE, A. PÉREZ-ESTAÚN, M. JOUBERT, D. WEIS

Publikováno v: Geologica Acta, Vol 9, Iss 3-4 (2011)

Located in Central Hispaniola, the Pelona-Pico Duarte basalts Formation (Fm.) offers an opportunity to study the Late Cretaceous Caribbean large igneous province magmatism on land. It is composed by a ~2.5km-thick pile of massive and monotonous subma

Externí odkaz: https://doaj.org/article/dda50156fde445789ebde93fb767844a

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Human B Cell Epitope Map of the Lyme Disease Vaccine Antigen, OspA

Autor: H. M. Emranul Haque, Monir Ejemel, David J. Vance, Graham Willsey, Michael J. Rudolph, Lisa A. Cavacini, Yang Wang, Nicholas J. Mantis, David D. Weis

Publikováno v: ACS Infectious Diseases. 8:2515-2528

The Lyme disease (LD) vaccine formerly approved for use in the United States consisted of recombinant outer surface protein A (OspA) from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679f608a3f20256d6f13d185b32211fa
https://doi.org/10.1021/acsinfecdis.2c00346

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Akademický článek

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High-Throughput Epitope Mapping by Hydrogen Exchange-Mass Spectrometry

Autor: H. M. Emranul Haque, Nicholas J. Mantis, David D. Weis

Publikováno v: Journal of the American Society for Mass Spectrometry. 34(1)

In this paper, we introduce a screening protocol for epitope mapping by hydrogen exchange mass spectrometry (HX-MS) that has higher throughput than a traditional HX-MS epitope mapping. In the screening protocol, three HX labeling times (20, 1000, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2571a3db56ffecb947fe86541b1d9b7
https://pubmed.ncbi.nlm.nih.gov/36449379

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Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete,Borreliella burgdorferi

Autor: Michael J. Rudolph, Simon A. Davis, H M Emranul Haque, David D. Weis, David J Vance, Carol Lyn Piazza, Monir Ejemel, Lisa Cavacini, Yang Wang, M. Lamine Mbow, Robert D. Gilmore, Nicholas J Mantis

Outersurfaceprotein C (OspC) plays a pivotal role in mediating tick-to-host transmission and infectivity of the Lyme disease spirochete,Borreliella burgdorferi. OspC is a helical-rich homodimer that interacts with tick salivary proteins, as well as c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7afeff799c470b8a3eae5dfe9a85cb20
https://doi.org/10.1101/2022.11.28.518297

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Akademický článek

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Rapid Assessment of Pepsin Column Activity for Reliable HDX-MS Studies

Autor: Juan Pablo Rincon Pabon, Clint Vorauer, Michael S. Wrigley, David D. Weis, Charlie C. Mundorff, Michael J. Watson, Miklos Guttman

Publikováno v: Journal of the American Society for Mass Spectrometry. 32:2386-2390

Hydrogen/deuterium exchange with mass spectrometry (HDX-MS) is a widely used technique to probe protein structural dynamics, track conformational changes, and map protein-protein interactions. Most HDX-MS studies employ a bottom-up approach utilizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f2be57c27ab777cb70adfa2870237
https://doi.org/10.1021/jasms.1c00080

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In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats

Autor: Chen Yan, Michael T. Kim, Sharmila Rajan, Vittal Shivva, Martin Lechmann, Aron Lee, David D. Weis

Publikováno v: Journal of Pharmaceutical Sciences. 110:1989-1996

While free thiols in monoclonal antibodies (mAbs) have been extensively characterized by in vitro studies to probe its effect on antibody function and stability, their in vivo biotransformation has not been comprehensively studied. In this study, a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c19ae443487b067bad5ee8fa3198a1
https://doi.org/10.1016/j.xphs.2021.02.009

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Statistical Equivalence Testing of Higher-Order Protein Structures with Differential Hydrogen Exchange-Mass Spectrometry (HX-MS)

Autor: Michael S. Wrigley, Tyler S. Hageman, David D. Weis

Publikováno v: Analytical Chemistry. 93:6980-6988

Hydrogen exchange-mass spectrometry (HX-MS) is widely recognized for its potential utility for establishing the equivalence of the higher-order structures of proteins, particularly in comparability and similarity contexts. However, recent progress in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9272f83ac48b1dae8fef29c101dcd2a0
https://doi.org/10.1021/acs.analchem.0c05279

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