Zobrazeno 1 - 10 of 71 pro vyhledávání: '"D. W. Pfaff"'
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Akademický článek
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents
Autor: S. Gao, A. Proekt, N. Renier, D. P. Calderon, D. W. Pfaff
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The reticular activating system (RAS) of the brainstem regulates wakefulness, and stimulation of RAS areas can reverse effects of anaesthesia. Here, the authors show that stimulation of a particular RAS area, the anterior portion of nucleus gigantoce
Externí odkaz: https://doaj.org/article/9f743d8f239245c0a4937e673cd9d525
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2
Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3α,5α-THP-facilitated lordosis
Autor: Kanako Sumida, Cheryl A. Frye, B. W. O’Malley, D. W. Pfaff, John P. Lydon
Publikováno v: Psychopharmacology. 185:423-432
Progesterone (P) and its 5alpha-reduced metabolite, 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP), facilitate sexual behavior of rodents via agonist-like actions at intracellular progestin receptors (PRs) and membrane GABA(A)/benzodiazepin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401d376828b630fa41e8d9850c603d1b
https://doi.org/10.1007/s00213-005-0300-4
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4
CB1 receptor signaling regulates social anxiety and memory
Autor: Y, Litvin, A, Phan, M N, Hill, D W, Pfaff, B S, McEwen
Publikováno v: Genes, brain, and behavior. 12(5)
The endocannabinoid (eCB) system regulates emotion, stress, memory and cognition through the cannabinoid type 1 (CB1 ) receptor. To test the role of CB1 signaling in social anxiety and memory, we utilized a genetic knockout (KO) and a pharmacological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84be43c7088e633328f2d805adbf155d
https://pubmed.ncbi.nlm.nih.gov/23647582
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5
Theoretical consequences of fluctuating versus constant liganding of oestrogen receptor-alpha in neurones
Autor: D W, Pfaff, A C, Ribeiro
Publikováno v: Journal of neuroendocrinology. 22(6)
A theory is put forward that emphasises differences in neuronal responses to fluctuations in steroid hormone levels compared to constant hormone levels. We propose that neuronal functions that regulate gonadotrophin release from the anterior pituitar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97ca4e0cb0c22e82b791fea10a9ef20a
https://pubmed.ncbi.nlm.nih.gov/19912478
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6
Voltage-dependent calcium channels in ventromedial hypothalamic neurones of postnatal rats: modulation by oestradiol and phenylephrine
Autor: A W, Lee, A, Kyrozis, V, Chevaleyre, L-M, Kow, J, Zhou, N, Devidze, Q, Zhang, A M, Etgen, D W, Pfaff
Publikováno v: Journal of neuroendocrinology. 20(2)
Oestradiol actions in the hypothalamus play an important role in reproductive behaviour. Oestradiol treatment in vivo induces alpha(1b)-adrenoceptor mRNA and increases the density of alpha(1B)-adrenoceptor binding in the hypothalamus. Oestradiol is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8d9788ff883aca6da3c917ca9507bf3
https://pubmed.ncbi.nlm.nih.gov/18088362
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7
Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior
Autor: A K, Ragnauth, N, Devidze, V, Moy, K, Finley, A, Goodwillie, L-M, Kow, L J, Muglia, D W, Pfaff
Publikováno v: Genes, brain, and behavior. 4(4)
Compared to results from a generation of neuropharmacological work, the phenotype of mice lacking the oxytocin (OT) peptide gene was remarkably normal. An important component of the current experiments was to assay OT-knockout (OTKO) and wild-type (W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::888fa91a18482723e20b3361873cea01
https://pubmed.ncbi.nlm.nih.gov/15924555
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8
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors
Autor: Cheryl A. Frye, John P. Lydon, Madeline E. Rhodes, Jacob P. Harney, Bruce C. Dudek, Kanako Sumida, B. W. O’Malley, D. W. Pfaff
Publikováno v: Psychopharmacology. 186(3)
Aging is associated with reduced secretion of, and down-regulation of receptors for, progesterone (P); yet, P's effects when administered to younger and older animals have not been systematically investigated. Some of P's antianxiety effects may be d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71b1c5f03f9a58b5d575781d9b1a839
https://pubmed.ncbi.nlm.nih.gov/16538472
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10
Enhanced up-regulation of corticotropin-releasing hormone gene expression in response to restraint stress in the hypothalamic paraventricular nucleus of oxytocin gene-deficient male mice
Autor: M, Nomura, J, Saito, Y, Ueta, L J, Muglia, D W, Pfaff, S, Ogawa
Publikováno v: Journal of neuroendocrinology. 15(11)
The neuropeptide oxytocin is released not only into the blood, but also within the brain in response to various stressors. Accumulating evidence suggests that central oxytocin may play a major role in the regulation of neuroendocrine responses to str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::726126dfa245b8ffa2906ae731e04da2
https://pubmed.ncbi.nlm.nih.gov/14622435
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