Zobrazeno 1 - 10 of 129 pro vyhledávání: '"D. W. Nebert"'
1
Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles
Autor: M, Ingelman-Sundberg, M, Oscarson, A K, Daly, S, Garte, D W, Nebert
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(12)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4625f4d673a22a467cad814e042f64b
https://pubmed.ncbi.nlm.nih.gov/11751452
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2
Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements
Autor: M Z, Dieter, S L, Freshwater, W A, Solis, D W, Nebert, T P, Dalton
Publikováno v: Biochemical pharmacology. 61(2)
To investigate a possible role of phosphorylation in the signal transduction pathways responsible for transcriptional regulation of drug-metabolizing enzymes, we tested seven specific tyrosine kinase inhibitors (tyrphostins) for their effects on NAD(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba519fc7e8eb9e6552cf93f8c38c596e
https://pubmed.ncbi.nlm.nih.gov/11163336
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3
Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?
Autor: D W, Nebert
Publikováno v: Clinical genetics. 56(4)
Adverse drug reactions, due at least in part to interindividual variability in drug response, rank between the 4th and 6th leading causes of death in the USA. The field of 'pharmacogenetics', which is 'the study of variability in drug response due to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1dc1eba08820812899035a254a04ce8a
https://pubmed.ncbi.nlm.nih.gov/10636440
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4
CYP2D1 polymorphism in methamphetamine-treated rats: genetic differences in neonatal mortality and effects on spatial learning and acoustic startle
Autor: C V, Vorhees, T M, Reed, M A, Schilling, J E, Fisher, M S, Moran, G D, Cappon, D W, Nebert
Publikováno v: Neurotoxicology and teratology. 20(3)
d-Methamphetamine (MA) is one of more than two dozen drugs included in the cytochrome P450-mediated "debrisoquine oxidation polymorphism" panel. The human gene (CYP2D6) is responsible for the "poor metabolizer" (PM) and "extensive metabolizer" (EM) p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f9ad8605dc79574fc7c66bb10726ca9
https://pubmed.ncbi.nlm.nih.gov/9638684
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5
Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes
Autor: J, Gu, Q Y, Zhang, M B, Genter, T W, Lipinskas, M, Negishi, D W, Nebert, X, Ding
Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(3)
The metabolic activation of two known olfactory mucosal (OM) toxicants, acetaminophen (AP) and 2,6-dichlorobenzonitrile (DCBN), was examined with mouse liver and OM microsomes and purified, heterologously expressed mouse CYP2A5 and CYP2G1. In reconst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::559aaaa6edc9d38271fb2022584c55ed
https://pubmed.ncbi.nlm.nih.gov/9618435
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7
1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent
Autor: P J, Wedlund, S, Kimura, F J, Gonzalez, D W, Nebert
Publikováno v: Pharmacogenetics. 4(1)
A 15-member three-generation family of Eastern Mediterranean descent was previously studied, and an association between CYP1A1 (cytochrome P1450, benzo[a]pyrene hydroxylase) inducibility and a CYP1A1 3'-polymorphism (the Msp I 1.9 kb allele) was repo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c362138939983b7ef0380a113151b4e
https://pubmed.ncbi.nlm.nih.gov/7516235
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9
Drug metabolism and signal transduction: possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity
Autor: D W, Nebert
Publikováno v: EXS. 71
It has become increasingly clear that the so-called 'drug-metabolizing enzymes,' and the receptors controlling them, play a key role in regulating the steady-state levels of ligands important in the transcription of genes involved in cell division, d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85609bb1c50fa683338b8d14a96543b3
https://pubmed.ncbi.nlm.nih.gov/8032154
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10
Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Autor: L D, Teeter, D D, Petersen, D W, Nebert, M T, Kuo
Publikováno v: DNA and cell biology. 10(6)
Multidrug-resistance (MDR) genes are induced in the liver of rodents treated with a variety of foreign chemicals and hepatocarcinogens. It has been reported that 2,3,6,7-tetrachlorodibenzo-p-dioxin (TCDD) might increase hepatic MDR transcripts in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9effc8ed3c80d402847d2f070c5c3d4
https://pubmed.ncbi.nlm.nih.gov/2069718
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