Zobrazeno 1 - 2
of 2
pro vyhledávání: '"D. W. Mellini"'
Autor:
R W, Nims, R M, McClain, P S, Manchand, P S, Belica, P E, Thomas, D W, Mellini, W E, Utermahlen, R A, Lubet
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(1)
To explore further the structural requirements for ligand interaction with the putative phenobarbital receptor, the pharmacodynamics of CYP2B induction by 5,5-diphenylbarbituric acid, phenytoin (5,5-diphenylhydantoin), barbital (5,5-diethylbarbituric
Autor:
R W Nims, J. F. Sinclair, D. W. Mellini, Konstantin H. Dragnev, Ronald A. Lubet, P. R. Sinclair, Paul E. Thomas, Collins R. Jones
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 23(12)
1. The dose-response relationships for hepatic CYP2B induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) were examined in the male F344/NCr rat. TCPOBOP, administered for 14 days at 0-1000 ppm in the diet, caused concentration-dependent