Zobrazeno 1 - 10
of 22
pro vyhledávání: '"D. W. Howie"'
Publikováno v:
The Journal of Bone and Joint Surgery. British volume. :311-315
Our aim was to determine whether in vitro studies would detect differences in the cellular response to wear particles of two titanium alloys commonly used in the manufacture of joint replacement prostheses. Particles were of the order of 1 μm in dia
Publikováno v:
The Journal of bone and joint surgery. British volume. 83(6)
Extensive osteolysis adjacent to implants is often associated with wear particles of prosthetic material. We have investigated if RANKL, also known as osteoprotegerin ligand, osteoclast differentiation factor or TRANCE, and its natural inhibitor, ost
Publikováno v:
The Journal of bone and joint surgery. British volume. 82(8)
We studied the effect of the surface finish of the stem on the transfer of load in the proximal femur in a sheep model of cemented hip arthroplasty. Strain-gauge analysis and corresponding finite-element (FE) analysis were performed to assess the eff
Autor:
S D, Neale, Y, Fujikawa, A, Sabokbar, R, Gundle, D W, Murray, S E, Graves, D W, Howie, N A, Athanasou
Publikováno v:
The Journal of bone and joint surgery. British volume. 82(6)
Mononuclear osteoclast precursors are present in the wear-particle-associated macrophage infiltrate found in the membrane surrounding loose implants. These cells are capable of differentiating into osteoclastic bone-resorbing cells when co-cultured w
Publikováno v:
Clinical orthopaedics and related research. (363)
The periacetabular osteotomy is a well established surgical procedure for the preventative treatment of degenerative joint disease caused by symptomatic acetabular dysplasia. Surgeons on several continents use varying surgical approaches to achieve t
Publikováno v:
The Journal of bone and joint surgery. British volume. 80(4)
We have compared prospectively the incidence of loosening of 20 femoral stems with a matt surface with that of 20 polished stems of an otherwise identical tapered, non-modular design of Exeter hip replacement. The stems were inserted using the same t
Publikováno v:
Clinical orthopaedics and related research. (352)
Particles of prosthetic material stimulate macrophages to release cytokines, which may cause bone loss and loosening of the prosthesis. This study investigates the possibility that particles of different prosthetic materials may induce different cyto
Publikováno v:
The Journal of bone and joint surgery. British volume. 79(6)
We report a prospective randomly controlled trial to examine the effectiveness of continuous passive motion (CPM) in improving postoperative function and range of movement after total knee arthroplasty (TKA). We allocated 53 patients (57 knees) to on
Publikováno v:
The Journal of bone and joint surgery. British volume. 79(6)
Bone loss around replacement prostheses may be related to the activation of mononuclear phagocytes (MNP) by prosthetic wear particles. We investigated how osteoblast-like cells were regulated by human MNP stimulated by particles of prosthetic materia
Publikováno v:
The Orthopedic clinics of North America. 24(4)
The most common cause of failure of total hip and other arthroplasties is aseptic loosening of the prosthesis. Substantial evidence suggests that the adverse tissue response to prosthesis wear particles is an important contributor to bone loss around