Výsledky vyhledávání - "D. W. Gaylor"

A unified approach to risk assessment for cancer and noncancer endpoints based on benchmark doses and uncertainty/safety factors

Autor: D W, Gaylor, R L, Kodell, J J, Chen, D, Krewski

Publikováno v: Regulatory toxicology and pharmacology : RTP. 29(2 Pt 1)

A fundamental goal of toxicology is to determine safe levels of human exposure to toxic substances. In the absence of information to establish dose-response relationships at low exposure levels generally experienced by humans, high-dose to low-dose l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c049a506a4bac008d96bdfedfa44bbf5
https://pubmed.ncbi.nlm.nih.gov/10341145

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On the correlation coefficient between the TD50 and the MTD

Autor: M, Razzaghi, D W, Gaylor

Publikováno v: Risk analysis : an official publication of the Society for Risk Analysis. 16(1)

The existence of correlation between the carcinogenic potency and the maximum tolerated dose has been the subject of many investigations in recent years. Several attempts have been made to quantify this correlation in different bioassay experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8200b1d4415b3a472f3097439adbdf55
https://pubmed.ncbi.nlm.nih.gov/8868225

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Spontaneous renal tubular carcinoma in Fischer-344 rat littermates

Autor: J. R. Hailey, D. W. Gaylor, A. Turturro, J. D. Thurman

Publikováno v: Veterinary pathology. 32(4)

Two of 632 Fischer-344 rats in a food restriction study had spontaneous, bilateral, multicentric renal tubular cell carcinomas. Although there were 104 litters represented in this study, both rats that developed this rare neoplasm were from the same

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f740895d51c92de108b963df84dc2c11
https://pubmed.ncbi.nlm.nih.gov/7483218

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International trends in the incidence of bone cancer are not related to drinking water fluoridation

Autor: S C, Freni, D W, Gaylor

Publikováno v: Cancer. 70(3)

Because osteosarcomas may develop in rats exposed to fluoridated water, water fluoridation might pose a cancer risk to humans.A time trend analysis of the cumulative risk (CR) of bone cancer for the period 1958-1987 for 40 cancer registry areas showe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b870c62cafe526165cb5b30157cc8d20
https://pubmed.ncbi.nlm.nih.gov/1623476

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Analysis of trinomial responses from reproductive and developmental toxicity experiments

Autor: J J, Chen, R L, Kodell, R B, Howe, D W, Gaylor

Publikováno v: Biometrics. 47(3)

This paper presents a Dirichlet-trinomial distribution for modelling data obtained from reproductive and developmental studies. The common endpoints for the evaluation of reproductive and developmental toxic effects are the number of dead fetuses, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0384978fda36843d75ea5c08b0348343
https://pubmed.ncbi.nlm.nih.gov/1742429

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Risk assessment for neurotoxic effects

Autor: D W, Gaylor, W, Slikker

Publikováno v: Neurotoxicology. 11(2)

Regulation of neurotoxicants is generally based on setting allowable doses (exposures) by dividing a no observed adverse effect level (NOAEL) by uncertainty factors that hopefully account for interspecies and intraspecies differences for extrapolatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89d69b49853c067328571466a891d58f
https://pubmed.ncbi.nlm.nih.gov/1700346

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