Zobrazeno 1 - 10 of 11 pro vyhledávání: '"D. W., Zaharevitz"'
1
All-Atom Models for the Non-Nucleoside Binding Site of HIV-1 Reverse Transcriptase Complexed with Inhibitors: A 3D QSAR Approach
Autor: John W. Erickson, Igor A. Topol, Catherine A. Schaeffer, Glen E. Kellogg, Rick Gussio, D. W. Zaharevitz, Stanley K. Burt, William G. Rice, Nagarajan Pattabiraman
Publikováno v: Journal of Medicinal Chemistry. 39:1645-1650
Several molecular modeling techniques were used to generate an all-atom molecular model of a receptor binding site starting only from Ca atom coordinates. The model consists of 48 noncontiguous residues of the non-nucleoside binding site of HIV-1 rev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5313248769082db97d1206b5411df527
https://doi.org/10.1021/jm9508088
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3
Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies
Autor: Pies, T., K. J., Schaper, Leost, M., D. W., Zaharevitz, Gussio, R., Meijer, L., Kunicke, C.
Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2004, 23, pp.8206-8215
Oncogene, 2004, 23, pp.8206-8215
Dysregulation of the centrosome duplication cycle has been implicated in tumorigenesis. Our previous work has shown that the human papillomavirus type 16 (HPV-16) E7 oncoprotein rapidly induces aberrant centrosome and centriole duplication in normal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4e65410a409b83fd1e6458a66d1dc3b2
https://hal.archives-ouvertes.fr/hal-00018945
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4
Pharmacological inhibitors of glycogen synthase kinase 3
Autor: Pies, T., K. J., Schaper, Leost, M., D. W., Zaharevitz, Gussio, R., Meijer, L., Kunicke, C.
Publikováno v: Trends in pharmacological sciences.
Trends in pharmacological sciences., 2004, 25, pp.471-480
Three closely related forms of glycogen synthase kinase 3 (GSK-3alpha, GSK-3beta and GSK-3beta2) have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0511ab0a67c2d13a8a26f5312484d1ac
https://hal.science/hal-00018947
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5
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25
Autor: M, Leost, C, Schultz, A, Link, Y Z, Wu, J, Biernat, E M, Mandelkow, J A, Bibb, G L, Snyder, P, Greengard, D W, Zaharevitz, R, Gussio, A M, Senderowicz, E A, Sausville, C, Kunick, L, Meijer
Publikováno v: European journal of biochemistry. 267(19)
Paullones constitute a new family of benzazepinones with promising antitumoral properties. They were recently described as potent, ATP-competitive, inhibitors of the cell cycle regulating cyclin-dependent kinases (CDKs). We here report that paullones
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d677bc6784c62306f196e69c33648095
https://pubmed.ncbi.nlm.nih.gov/10998059
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6
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
Autor: D W, Zaharevitz, R, Gussio, M, Leost, A M, Senderowicz, T, Lahusen, C, Kunick, L, Meijer, E A, Sausville
Publikováno v: Cancer research. 59(11)
Analysis of the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug Screen data using the COMPARE algorithm to detect similarities in the pattern of compound action to flavopiridol, a known inhibitor of cyclin-dependent kinases (CDKs), h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7337409c592b5997b344a4b16edcab32
https://pubmed.ncbi.nlm.nih.gov/10363974
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7
Vanadate inhibition of hyaluronic acid synthesis in Swiss 3T3 fibroblasts
Autor: D W, Zaharevitz, C A, Chisena, K L, Duncan, E M, August, R L, Cysyk
Publikováno v: Biochemistry and molecular biology international. 31(4)
Vanadate (50 microM) increases the incorporation of 3H from D-[1,6-3H]glucosamine into hyaluronic acid (HA) in serum stimulated Swiss 3T3 fibroblasts. This increase is not a result of increased HA synthesis, but is due to a significant increase in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a092cd5e93db6f811681b3a28fb7dd8c
https://pubmed.ncbi.nlm.nih.gov/7507761
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8
Rapid increase of cellular UDP-glucuronide after mitogen stimulation of quiescent 3T3 mouse fibroblasts
Autor: D W, Zaharevitz, C A, Chisena, R L, Cysyk
Publikováno v: Biochemistry international. 20(6)
Chromatographic analysis of the acid soluble nucleotide pool in 3T3 fibroblasts 30 minutes after serum stimulation revealed one component that was increased compared to quiescent controls. This component was identified as UDP-glucuronide by chromatog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d385102609c4cf586228f44d8505a6b
https://pubmed.ncbi.nlm.nih.gov/2196057
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10
Piecewise Polynomial Hylleraas Configuration Interaction Wavefunctions for Helium
Autor: Harris J. Silverstone, D. W. Zaharevitz, David M. Silver
Publikováno v: Supercomputer Applications ISBN: 9781461295143
The scientific problem treated in this work is that of describing the electronic structure of atoms and molecules with sufficient accuracy to be useful for predictions of chemical properties. The present activity consists of deriving computational so
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4539ce012cfda18c0921519fcc3607c1
https://doi.org/10.1007/978-1-4613-2503-1_18
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