Zobrazeno 1 - 10
of 155
pro vyhledávání: '"D. V. Parke"'
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 412:41-54
The molecular dimensions and electronic structures of the first group of 100 US NCI/NTP miscellaneous chemicals, evaluated for potential carcinogenicity by computer-optimized molecular parametric analysis for chemical toxicity (COMPACT) have been re-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eeb6dd13a3d87d72d3dc98f8f785f2
https://doi.org/10.1016/s1383-5718(97)00145-9
https://doi.org/10.1016/s1383-5718(97)00145-9
Publikováno v:
Environmental Health Perspectives
A new series of 30 miscellaneous National Toxicology Program chemicals has been evaluated prospectively for carcinogenicity and overt toxicity by COMPACT (Computer Optimised Molecular Parametric Analysis for Chemical Toxicity. CYP1A and CYP2E1). Eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223294f8a19e8c1da2b7582c0a12827c
https://doi.org/10.1289/ehp.96104s51011
https://doi.org/10.1289/ehp.96104s51011
Publikováno v:
Toxicology. 112:105-116
Ferrets were maintained for 12 months on different diets (A, meat and biscuit; B, all meat; C, meat and fish; D, high fibre) to ascertain the cause of spontaneous development of fatty liver. High hepatic triglyceride contents resulted on diets B = C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098d8df5b4bdfec06b1d52b4940c6197
https://doi.org/10.1016/0300-483x(96)03351-3
https://doi.org/10.1016/0300-483x(96)03351-3
Publikováno v:
Xenobiotica. 25:1355-1369
1. Molecular and electronic structural parameters have been determined, by molecular orbital (MO) calculations, for a homologous series of 8 alkoxyresorufins (methoxy- to octoxy-). 2. Quantitative structure-activity relationships (QSARs) between thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dc1dad4b24b9f6dd3249cb03c58dd9
https://doi.org/10.3109/00498259509061923
https://doi.org/10.3109/00498259509061923
Autor:
D. V. Parke, A. L. Parke
Publikováno v:
Inflammopharmacology
Chronic inflammatory disease, embracing rheumatoid arthritis (RA), inflammatory bowel disease (IBD), hepatitis, asthma, atherosclerosis, multiple system organ failure (MSOF), etc., is mediated by reactive oxygen species (ROS). These ROS originate fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e10ca385b4cb30913ec1b4281a24a23
http://europepmc.org/articles/PMC7101736
http://europepmc.org/articles/PMC7101736
Publikováno v:
Food and Chemical Toxicology. 32:1053-1059
A group of 19 acyclic terpenes have been evaluated for potential toxicity/carcinogenicity by molecular orbital determinations of their spatial and electronic parameters, and hence prediction of their metabolic activation or detoxication by the cytoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a456f504317b70ad2c0c9e4ee0336a9
https://doi.org/10.1016/0278-6915(94)90146-5
https://doi.org/10.1016/0278-6915(94)90146-5
Publikováno v:
Toxicology Letters. 71:235-243
The present studies were undertaken to provide a rationale for the observation that benzo( a )pyrene and 2-acetylaminofluorene induce the hepatic CYP1 A1 protein, whereas their non-carcinogenic isomers benzo( e )pyrene and 4-acetylaminofluorene are,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd4673254c16295fe4b8244b845685a
https://doi.org/10.1016/0378-4274(94)90110-4
https://doi.org/10.1016/0378-4274(94)90110-4
Publikováno v:
Drug Metabolism Reviews. 26:261-285
(1994). Molecular Modeling of Enzymes and Receptors Involved in Carcinogenesis: Qsars and Compacted-3D. Drug Metabolism Reviews: Vol. 26, No. 1-2, pp. 261-285.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97b2a38cb7d4d29f0f6a54f5d86b75c
https://doi.org/10.3109/03602539409029797
https://doi.org/10.3109/03602539409029797
Publikováno v:
Xenobiotica. 24:1063-1076
1. Ferret on a high fat diet accumulated large amounts of fat in its liver and had blood acetoacetate and beta-hydroxybutyrate concentrations 250 and 375% of those in control animals. 2. The high fat diet alone increased ferret liver microsomal 7-eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8268d9bb8e207771e7ba800b3f22cca5
https://doi.org/10.3109/00498259409038666
https://doi.org/10.3109/00498259409038666
Publikováno v:
Drug metabolism and drug interactions. 13(3)
The toxicity of chemicals, and of reactive oxygen species (ROS), are both affected by nutrition and diet. Calorific excess (continuous feeding), or deficiency (fasting), may increase production of ROS, which are also formed by interaction of toxic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a62be7a826f15112a37b738575b0dd4
https://pubmed.ncbi.nlm.nih.gov/21568810
https://pubmed.ncbi.nlm.nih.gov/21568810