Zobrazeno 1 - 10
of 45
pro vyhledávání: '"D. Travis Gallagher"'
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Autor:
Biao Ruan, Yanan He, Yingwei Chen, Eun Jung Choi, Yihong Chen, Dana Motabar, Tsega Solomon, Richard Simmerman, Thomas Kauffman, D. Travis Gallagher, John Orban, Philip N. Bryan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
In this work the authors investigate the structure-sequence dependance. The ability to design and characterize proteins at interfaces between three common folds suggests that fold switching is an intrinsic feature of protein folding language and like
Externí odkaz:
https://doaj.org/article/9524664bc44a413a9ca8a35fb258616e
Autor:
Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engi
Externí odkaz:
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Developing broadly applicable neoantigen-directed adoptive cell therapies (ACTs) is challenging because each cancer patient has an unique neoantigen repertoire. Here, the authors present the crystal structures of tumor-specific T cell receptors (TCRs
Externí odkaz:
https://doaj.org/article/539421cdbf2649ba84e049f00249ee1a
Autor:
Dario Spigolon, D. Travis Gallagher, Adrian Velazquez-Campoy, Donatella Bulone, Jatin Narang, Pier Luigi San Biagio, Francesco Cappello, Alberto J.L. Macario, Everly Conway de Macario, Frank T. Robb
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 66-71 (2017)
The human chaperonin complex is a ~ 1 MDa nanomachine composed of two octameric rings formed from eight similar but non-identical subunits called CCT. Here, we are elucidating the mechanism of a heritable CCT5 subunit mutation that causes profound ne
Externí odkaz:
https://doaj.org/article/c83304a489d4432581f66aefd5b7f84f
Autor:
D. Travis Gallagher, Chris McCullough, Robert G. Brinson, Joomi Ahn, John P. Marino, Nazzareno Dimasi
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 546 (2019)
Antibody-drug conjugates (ADCs) are a class of biotherapeutic drugs designed as targeted therapies for the treatment of cancer. Among the challenges in generating an effective ADC is the choice of an effective conjugation site on the IgG. One common
Externí odkaz:
https://doaj.org/article/09fb0c4bd2d441f2b015033ae9f88c2c
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:82-86
CRM197 is a genetically detoxified mutant of diphtheria toxin (DT) that is widely used as a carrier protein in conjugate vaccines. Protective immune responses to several bacterial diseases are obtained by coupling CRM197 to glycans from these pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb235ed30661432589822d0fd8f28e9f
https://doi.org/10.1107/s2053230x23002364
https://doi.org/10.1107/s2053230x23002364
Autor:
Tsega L. Solomon, Yanan He, Nese Sari, Yihong Chen, D. Travis Gallagher, Philip N. Bryan, John Orban
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Naturally occurring metamorphic proteins have the ability to interconvert from one folded state to another through either a limited set of mutations or by way of a change in the local environment. Here, we show in a designed system that it is possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da6d3fb27409a12ba14bcdcb89c5b11
https://doi.org/10.1073/pnas.2215418120
https://doi.org/10.1073/pnas.2215418120
Autor:
John Orban, Yihong Chen, Yanan He, David J. Weber, Eun Jung Choi, Raquel Godoy-Ruiz, Biao Ruan, D. Travis Gallagher, Melani Solomon, Thomas R. Fuerst, Ruixue Wang, David A. Rozak, Gregory S. Custer, Philip N. Bryan, Harlan King, Silvia Muro, Eric A. Toth, Yingwei Chen, Richard Simmerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by cleaving a conserved sequence in switch 2. RAS is a signaling protein that, when mutated, drives a third of human can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768ae163ddb6ebc0c904ea01793832d2
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Publikováno v:
Journal of Research of the National Institute of Standards and Technology. 126
As monoclonal antibodies have become a vital resource in medicine, knowledge of their complex molecular structures has increased in importance. Thousands of antibody components (Fab and Fc fragments) are described in the Protein Data Bank. Whole anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23c2317984e42c382415e103fb20f16
https://doi.org/10.6028/jres.126.012
https://doi.org/10.6028/jres.126.012