Zobrazeno 1 - 10
of 255
pro vyhledávání: '"D. Timm"'
Publikováno v:
Eleventh International Conference on the Bearing Capacity of Roads, Railways and Airfields, Volume 3 ISBN: 9781003222910
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b777c2ff192d13ec83b5e897268e52a
https://doi.org/10.1201/9781003222910-11
https://doi.org/10.1201/9781003222910-11
Akademický článek
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Autor:
Elan Z. Eisenmesser, Aaron Issaian, Stephen C. Rogers, David D. Timm, Jeff L.-F. Kao, Jaya Prakash, Julie A. Reisz, Xia Ge, Mary Brummet, Joel R. Garbow, Allan Doctor, Angelo D'Alessandro, Xue Lin, Andre d'Avignon
Publikováno v:
Transfusion
BACKGROUND: During storage, red blood cells (RBCs) undergo significant biochemical and morphologic changes, referred to collectively as the “storage lesion”. It was hypothesized that these defects may arise from disrupted oxygen-based regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aec2c31c842d8c4cfa179a93771f588
https://pubmed.ncbi.nlm.nih.gov/33830505
https://pubmed.ncbi.nlm.nih.gov/33830505
Autor:
Daumantas Matulis, Vaida Paketurytė, Edita Čapkauskaitė, David D. Timm, Asta Zubrienė, Sigitas Tumkevicius
Publikováno v:
Bioorganic Chemistry. 77:534-541
Four series of para or meta - substituted thiazolylbenzenesulfonamides bearing Cl substituents were designed, synthesized, and evaluated as inhibitors of all 12 catalytically active recombinant human carbonic anhydrase (CA) isoforms. Observed affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fa72d98e3be2ffec1a1f49bc19c52f
https://doi.org/10.1016/j.bioorg.2018.02.004
https://doi.org/10.1016/j.bioorg.2018.02.004
Akademický článek
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Autor:
David D. Timm, Jelena Jachno, Saulius Gražulis, Vaida Linkuvienė, Lina Baranauskienė, Asta Zubrienė, Alexey Smirnov, Jurgita Revuckienė, Abdul Waheed, Vilma Michailovienė, Aurelija Mickevičiūtė, Enrico Di Cera, Edita Čapkauskaitė, William S. Sly, Zhiwei Chen, Elena Manakova, Daumantas Matulis, Marius Gedgaudas, Jurgita Matulienė
Publikováno v:
European Biophysics Journal. 47:271-290
Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d90593a6085f4596ef71e4104dbf64
https://doi.org/10.1007/s00249-017-1256-0
https://doi.org/10.1007/s00249-017-1256-0
Autor:
Elena Manakova, Vilma Michailovienė, Asta Zubrienė, David D. Timm, Alexey Smirnov, Audrius Zakšauskas, Daumantas Matulis, Jurgita Matulienė, Virginija Dudutienė, Saulius Gražulis
Publikováno v:
ChemMedChem. 12:161-176
The goal of rational drug design is to understand structure-thermodynamics correlations in order to predict the chemical structure of a drug that would exhibit excellent affinity and selectivity for a target protein. In this study we explored the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfe160147c1dd22aa82c6cbae6c7c6f
https://doi.org/10.1002/cmdc.201600509
https://doi.org/10.1002/cmdc.201600509
Akademický článek
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Autor:
Stephen C. Rogers, Francis T. Moynihan, Allan Doctor, David D. Timm, Ryan McDonough, Elfaridah Frazier, Eyvind Hovmand‐Warner, Philip C. Spinella, Kimberly A. Thomas
Publikováno v:
Transfusion
BACKGROUND: We set out to define the impact of collection, processing, and storage on plasma product microparticle (MP) abundance, potential for nitric oxide (NO) scavenging, and vasoactivity. STUDY DESIGN AND METHODS: Three currently US licensed pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141c988c60d11dd922ca862495ace06a
https://pubmed.ncbi.nlm.nih.gov/30980740
https://pubmed.ncbi.nlm.nih.gov/30980740
Autor:
Asta Zubrienė, Justina Kazokaitė, Virginija Dudutienė, David D. Timm, Joana Smirnovienė, Elena Manakova, Daumantas Matulis, Alexey Smirnov, Saulius Gražulis, Audrius Zakšauskas, Vilma Michailovienė
Publikováno v:
ChemMedChem. 10:662-687
Substituted tri- and tetrafluorobenzenesulfonamides were designed, synthesized, and evaluated as high-affinity and isoform-selective carbonic anhydrase (CA) inhibitors. Their binding affinities for recombinant human CA I, II, VA, VI, VII, XII, and XI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02f40806543c3dfa5e7163cdc941489
https://doi.org/10.1002/cmdc.201402490
https://doi.org/10.1002/cmdc.201402490