Zobrazeno 1 - 10
of 666
pro vyhledávání: '"D. Tew"'
Autor:
G.-O. F. Gowers, S. M. Chee, D. Bell, L. Suckling, M. Kern, D. Tew, D. W. McClymont, T. Ellis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
SCRaMbLE can lead to great genetic diversity for product biosynthesis but is limited by screening methods. Here the authors develop a rapid workflow using automation, ultra-fast LC/MS and barcoded nanopore sequencing to identify best performing strai
Externí odkaz:
https://doaj.org/article/0a521b41817846ec8416988a01e7bb8f
Autor:
Jeffrey P. Townsend, Hayley B. Hassler, April D. Lamb, Pratha Sah, Aia Alvarez Nishio, Cameron Nguyen, Alexandra D. Tew, Alison P. Galvani, Alex Dornburg
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTSuccessive waves of infection by SARS-CoV-2 have left little doubt that this virus will transition to an endemic disease. Foreknowledge of when to expect seasonal surges is crucial for healthcare and public health decision-making. However, th
Externí odkaz:
https://doaj.org/article/5f2ee80989614ff4afac3241cb961543
Autor:
Leilei Zhang, Claudia M. Ludden, Alexander J. Cullen, Kenneth D. Tew, André Luís Branco de Barros, Danyelle M. Townsend
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115459- (2023)
In this mini-review, we discuss the role of NF-κB, a proinflammatory transcription factor, in the expression of genes involved in inflammation, proliferation, and apoptosis pathways, and link it with prognosis of various human cancers, particularly
Externí odkaz:
https://doaj.org/article/6a59c99872434363a3b346b863248ec3
Autor:
Jie Zhang, Zhi-wei Ye, Paramita Chakraborty, Zhenwu Luo, John Culpepper, Muhammad Aslam, Leilei Zhang, Katarina Johansson, Jesper Z. Haeggström, Jianqiang Xu, Magnus Olsson, Danyelle M. Townsend, Shikhar Mehrotra, Ralf Morgenstern, Kenneth D. Tew
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106899- (2023)
While recent targeted and immunotherapies in malignant melanoma are encouraging, most patients acquire resistance, implicating a need to identify additional drug targets to improve outcomes. Recently, attention has been given to pathways that regulat
Externí odkaz:
https://doaj.org/article/5d9d42b0e955458aadc407c65b31b648
Autor:
Aslam M. A. Mazari, Leilei Zhang, Zhi-Wei Ye, Jie Zhang, Kenneth D. Tew, Danyelle M. Townsend
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 688 (2023)
In humans, the cytosolic glutathione S-transferase (GST) family of proteins is encoded by 16 genes presented in seven different classes. GSTs exhibit remarkable structural similarity with some overlapping functionalities. As a primary function, GSTs
Externí odkaz:
https://doaj.org/article/cfe3261347ef461da534d32f3bcb5e60
Publikováno v:
European Journal of Engineering Education. :1-19
Autor:
Gavin Y. Wang, Kenneth D. Tew, Stephen P. Ethier, Bradley A. Schulte, Shenghui Qin, Aimin Yang
There is mounting evidence that cancer stem-like cells (CSC) are selectively enriched in residual tumors after anticancer therapies, which may account for tumor recurrence and metastasis by regenerating new tumors. Thus, there is a critical need to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7afa65abb7a957dbd464eb1b479a2c
https://doi.org/10.1158/0008-5472.c.6509574.v1
https://doi.org/10.1158/0008-5472.c.6509574.v1
Autor:
Kenneth D. Tew, Danyelle M. Townsend, Gavin Y. Wang, Annamarie C. Dalton, Ann-Marie Broome, Yu-Lin Jiang, Jennifer R. Bethard, Lauren E. Ball, Yefim Manevich, Zhiwei Ye, Jie Zhang, Leilei Zhang
Supplementary Figure S1. Effects of HO-1 knockdown in H460 cell lines and HO-1 over-expression in H596 cell lines. Supplementary Figure S2. Affinity Enrichment Mass Spectrometry. Supplementary Figure S3. ME-344 induced apoptosis in sensitive cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df95f93dbd8b4a935ec892fe6617a6f4
https://doi.org/10.1158/0008-5472.22422380.v1
https://doi.org/10.1158/0008-5472.22422380.v1
Autor:
Kenneth D. Tew, Danyelle M. Townsend, Gavin Y. Wang, Annamarie C. Dalton, Ann-Marie Broome, Yu-Lin Jiang, Jennifer R. Bethard, Lauren E. Ball, Yefim Manevich, Zhiwei Ye, Jie Zhang, Leilei Zhang
Antibodies. Primers. Click Chemistry and Affinity Enrichment Mass Spectrometry. Surface Plasmon Resonance - Biacore 3000 Kinetic Determinations. Co-Immunoprecipitation. Transfections with shRNA and plasmids. Plate colony formation assay. References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4af3189cf5be1b0176c1c02092dc19a
https://doi.org/10.1158/0008-5472.22422377.v1
https://doi.org/10.1158/0008-5472.22422377.v1
Autor:
Kenneth D. Tew, Danyelle M. Townsend, Gavin Y. Wang, Annamarie C. Dalton, Ann-Marie Broome, Yu-Lin Jiang, Jennifer R. Bethard, Lauren E. Ball, Yefim Manevich, Zhiwei Ye, Jie Zhang, Leilei Zhang
ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are naturally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d6592241410b1bfe0f4cd9def7ffcb
https://doi.org/10.1158/0008-5472.c.6511193
https://doi.org/10.1158/0008-5472.c.6511193