Opportunities for the replacement of animals in the study of nausea and vomiting

Autor: F D Tattersall, Qasim Aziz, Anthony M. Holmes, P. L. R. Andrews, John A. Rudd

Publikováno v: British Journal of Pharmacology. 157:865-880

Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments. Developing novel anti-emetics and identifying emetic liability in novel chemical entities rely on models that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::082c57cdef0230ae7d75b2ba62baa1b7
https://doi.org/10.1111/j.1476-5381.2009.00176.x

An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

Autor: Neil Collinson, B. J. Everitt, Guy R. Seabrook, Keith A. Wafford, F. D. Tattersall, David S. Reynolds, M. Cobain, W. Rycroft, Angus Murray Macleod, Hedaythul Choudhury, John R. Atack, Goplan V. Pillai, Gerard R. Dawson, L. M. McDonald, Alison J. Smith, F. Sternfeld, Karen A. Maubach

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 316:1335-1345

Alpha5IA is a compound that binds with equivalent subnanomolar affinity to the benzodiazepine (BZ) site of GABA(A) receptors containing an alpha1, alpha2, alpha3, or alpha5 subunit but has inverse agonist efficacy selective for the alpha5 subtype. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9974698d763c91ef244a0d03e364dfbb
https://doi.org/10.1124/jpet.105.092320

The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex

Autor: L. Singh, Linda J. Bristow, Paul D. Leeson, Brian John Williams, Peter H. Hutson, Mark D. Tricklebank, F. D. Tattersall, Michael Rowley, L. Thorn, K. L. Saywell

Publikováno v: British Journal of Pharmacology. 113:729-736

1. The anticonvulsant and behavioural effects of the glycine/NMDA receptor partial agonist, L-687,414 (R(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one) have been investigated in rodents. 2. L-687,414 dose-dependently antagonized seizures induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0008ac0b50d7ca3fca8462b14ada314
https://doi.org/10.1111/j.1476-5381.1994.tb17054.x

Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Colorectal Cancer Symptomatic Patients

Autor: Steve Halligan, Katherine Wooldrage, Edward Dadswell, Urvi Shah, Ines Kralj-Hans, Christian von Wagner, Omar Faiz, Julian Teare, Rob Edwards, Clive Kay, Guiqing Yao, Richard J. Lilford, Dion Morton, Jane Wardle, Wendy Atkin, E. Dadswell, R. Kanani, K. Wooldrage, P. Rogers, U. Shah, I. Kralj-Hans, A. Ghanouni, J. Waddingham, K. Pack, A. Thomson, L. Turner, C. Monk, A. Verjee, S. Smith, C. von Wagner, J. Wardle, R.J. Lilford, G. Yao, S. Zhu, D. Burling, A. Higginson, C.L. Kay, G.F. Maskell, A. Taylor, S.J. Hayward, D. Cade, D. Morton, R. Dhingsa, J.C. Jobling, S.A. Jackson, D. Blunt, M.K. Neelala, S.A. Sukumar, A. Slater, P. Ziprin, D. Edwards, P. Woolfall, J. Muckian, D. Bastable, N. Gibbons, K. Flashman, L. Coni, J. Martin, S. Stephenson, C. Jackson, D. Beech, C. Lynn, H. Arumugam, S. Wilkinson, J. Scothern, L. Pickles, A. Hennedy, T. Larkin, P. Pearson, S. Preston, L. Smith, L. Wright, J. Blackstock, R. Thomas, S. Allen, L. Young, V. Adamson, J. Butler-Barnes, T. Larcombe, V. Bradshaw, S. Chapman, M. Slater, J. Stylan, D. Wood, J. Bradbury, J. Breedon, M. Coakes, L. Crutch, A. Leyland, W. Pringle, L. Rowe, M. White, D. Kumar, A. Worley, M. Gandy, E. Whitehead, J. Pascoe, M. Avery, D. Shivapatham, S. Thomas, C. Ong, B. Poppinga-Scholz, J. Stove, K. Pearson, J. Wood, W. Cook, Y. Memory, K. Fellows, A. Duffy, A. Usansky, B. Shanahan, F. Naim, V. Bohra, S. Prabhudesai, N. Lancelotte, M. Hayes, T. James, S. Johnston, J. Stevenson, D. Whetter, C. Bartram, A. Gupta, M. Marshall, S.A. Taylor, J. Atchley, A. Lowe, A. Wormald, C. Bloor, E. Tan, J. McGregor, A. Philips, M. Noakes, S. Zaman, P. Guest, I. McCafferty, P. Riley, D. Tattersall, B.M. Fox, J. Shirley, M. Roddie, A. Owen, N. Hughes, J.M.A. Northover, B. Saunders, P. Goggin, D. O’Leary, J. Ausobsky, C. Beckett, J. Davies, J. Griffith, M. Steward, P.J. Arumugam, C. Bronder, C. Brown, I. Crighton, A. Higham, R. Lea, C. Meaden, W. Morgan, P. Patel, G. Nasmyth, M. Williamson, J. Scholefield, K. Hosie, D. Bansi, G. Buchanan, P. Dawson, G. Smith, N.A. Theodorou, A. Thillainayagam, P. Conlong, B. Rameh, A. Rate, D. Richards, G.M. Hyde, D.J. Jones, S.T. O’Dwyer, C. Cunningham, S. Travis, S. Burton, P. Fabricius, M. Gudgeon, I. Jourdan, M. Rutter, A. Dixon, L. Faulds-Wood, T. Marteau, R. Valori, D.G. Altman, R. Steele, A. Walker

Publikováno v: Gastroenterology. 149:89-101.e5

Background & Aims Symptoms suggestive of colorectal cancer may originate outside the colorectum. Computed tomographic colonography (CTC) is used to examine the colorectum and abdominopelvic organs simultaneously. We performed a prospective randomized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2e7a221a8577844a37f0b47781dc2b
https://doi.org/10.1053/j.gastro.2015.03.011

A crispa null mutant facilitates identification of a crispa-like pseudogene in pea

Autor: Alexander D. Tattersall, Frank Sainsbury, Julie M.I. Hofer, T. H. Noel Ellis, Mike Ambrose, Lynda Turner

Publikováno v: Functional plant biology : FPB. 33(8)

The genomes of several legume species contain two Phantastica-like genes. Previous studies on leaf development have found that Phantastica confers leaf blade adaxial identity in plant species with simple leaves and leaflet adaxial identity in pea (Pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5609fdb2b0e775bad71c9f01f57dc20
https://pubmed.ncbi.nlm.nih.gov/32689286